Cell counting in human endobronchial biopsies--disagreement of 2D versus 3D morphometry

Inflammatory cell numbers are important endpoints in clinical studies relying on endobronchial biopsies. Assumption-based bidimensional (2D) counting methods are widely used, although theoretically design-based stereologic three-dimensional (3D) methods alone offer an unbiased quantitative tool. We...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92510
Hauptverfasser:	Bratu, Vlad A, Erpenbeck, Veit J, Fehrenbach, Antonia, Rausch, Tanja, Rittinghausen, Susanne, Krug, Norbert, Hohlfeld, Jens M, Fehrenbach, Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Asthma Bias Biology and Life Sciences Biomedical research Biopsy Bronchi Bronchi - pathology Bronchus CD3 antigen Cell Count - methods Chronic obstructive pulmonary disease Computer simulation Counting Counting methods Deviation Embedded systems Female Humans Immunohistochemistry Inflammation Inflammation - pathology Lung diseases Lymphocytes Lymphocytes T Macrophages Male Medical research Medicine Medicine and Health Sciences Microscopy Middle Aged Morphometry Nuclei Nuclei (cytology) Regression analysis Reproducibility of Results Research and Analysis Methods Smokers Smoking Studies Toxicology
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