Necrotising enterocolitis in preterm infants: epidemiology and antibiotic consumption in the Polish neonatology network neonatal intensive care units in 2009
The aim of this study was to describe the epidemiology of necrotising enterocolitis (NEC), antibiotic consumption and the usefulness of microbiological tests in very low birth weight (VLBW) Polish newborns. Prospective surveillance was performed in the year 2009 by local infection control teams. The...
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| Veröffentlicht in: | PloS one 2014-03, Vol.9 (3), p.e92865-e92865 |
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| creator | Wójkowska-Mach, Jadwiga Różańska, Anna Borszewska-Kornacka, Maria Domańska, Joanna Gadzinowski, Janusz Gulczyńska, Ewa Helwich, Ewa Kordek, Agnieszka Pawlik, Dorota Szczapa, Jerzy Heczko, Piotr B |
| description | The aim of this study was to describe the epidemiology of necrotising enterocolitis (NEC), antibiotic consumption and the usefulness of microbiological tests in very low birth weight (VLBW) Polish newborns.
Prospective surveillance was performed in the year 2009 by local infection control teams. The study covered 910 infants hospitalized in six Polish neonatal intensive care units. Two kinds of indicators were used for the description of antibiotic usage: the duration of treatment (days of treatment, DOTs) and the defined daily dose (DDD).
NEC incidence was 8.7% and fatality rate was 19%. Chorioamnionitis, late gestational age and low birth weight were identified as risk factors for NEC. Catheterization, mechanical ventilation and other selected procedures were used considerably longer in newborns with NEC than in the remaining neonates. Total usage of antibiotics reached 2.9 DDDs or 1.437 days; the average use of drugs per case of NEC amounted to 0.47 DDD or 23.2 DOTs. The level of antibiotic usage was analysed with correlation to microbiological tests performed and it was non-significantly greater in the group of children with NEC in whom the tests were performed.
A high risk of developing NEC is closely associated with VLBW and with inflammation of the amnion during labour. We observed no relationship between the consumption of antibiotics in neonates with NEC and positive results of microbiological testing indicating sepsis accompanying NEC or gut colonization with pathogens. |
| doi_str_mv | 10.1371/journal.pone.0092865 |
| format | Article |
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Prospective surveillance was performed in the year 2009 by local infection control teams. The study covered 910 infants hospitalized in six Polish neonatal intensive care units. Two kinds of indicators were used for the description of antibiotic usage: the duration of treatment (days of treatment, DOTs) and the defined daily dose (DDD).
NEC incidence was 8.7% and fatality rate was 19%. Chorioamnionitis, late gestational age and low birth weight were identified as risk factors for NEC. Catheterization, mechanical ventilation and other selected procedures were used considerably longer in newborns with NEC than in the remaining neonates. Total usage of antibiotics reached 2.9 DDDs or 1.437 days; the average use of drugs per case of NEC amounted to 0.47 DDD or 23.2 DOTs. The level of antibiotic usage was analysed with correlation to microbiological tests performed and it was non-significantly greater in the group of children with NEC in whom the tests were performed.
A high risk of developing NEC is closely associated with VLBW and with inflammation of the amnion during labour. We observed no relationship between the consumption of antibiotics in neonates with NEC and positive results of microbiological testing indicating sepsis accompanying NEC or gut colonization with pathogens.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0092865</identifier><identifier>PMID: 24658445</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amnion ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Babies ; Bioethics ; Birth weight ; Catheterization ; Children ; Chorioamnionitis ; Colonization ; Consumption ; Correlation analysis ; Dosage ; Drugs ; Enterocolitis ; Enterocolitis, Necrotizing - diagnosis ; Enterocolitis, Necrotizing - drug therapy ; Enterocolitis, Necrotizing - epidemiology ; Enterocolitis, Necrotizing - microbiology ; Epidemiology ; Female ; Gastrointestinal diseases ; Gestational age ; Health aspects ; Hospitals ; Humans ; Incidence ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - drug therapy ; Infant, Premature, Diseases - epidemiology ; Infants ; Infection ; Infection control ; Infections ; Intensive care ; Intensive care units ; Intensive Care Units, Neonatal ; Low birth weight ; Male ; Mechanical properties ; Mechanical ventilation ; Medical research ; Medicine and Health Sciences ; Microbiology ; Necrosis ; Neonates ; Newborn babies ; Pathogenesis ; Pathogens ; Patient Outcome Assessment ; Pediatrics ; Poland ; Premature babies ; Premature infants ; Prospective Studies ; Public Health Surveillance ; Research and Analysis Methods ; Risk analysis ; Risk Factors ; Sepsis ; Studies ; Surveillance ; Systematic review ; Ventilation</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e92865-e92865</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Wójkowska-Mach et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Wójkowska-Mach et al 2014 Wójkowska-Mach et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e2d85c71029cd22da320739d03c027e9f6d2dc37bfeb5d4346c5fba614d90a513</citedby><cites>FETCH-LOGICAL-c692t-e2d85c71029cd22da320739d03c027e9f6d2dc37bfeb5d4346c5fba614d90a513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962467/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962467/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24658445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rogers, Lynette K.</contributor><creatorcontrib>Wójkowska-Mach, Jadwiga</creatorcontrib><creatorcontrib>Różańska, Anna</creatorcontrib><creatorcontrib>Borszewska-Kornacka, Maria</creatorcontrib><creatorcontrib>Domańska, Joanna</creatorcontrib><creatorcontrib>Gadzinowski, Janusz</creatorcontrib><creatorcontrib>Gulczyńska, Ewa</creatorcontrib><creatorcontrib>Helwich, Ewa</creatorcontrib><creatorcontrib>Kordek, Agnieszka</creatorcontrib><creatorcontrib>Pawlik, Dorota</creatorcontrib><creatorcontrib>Szczapa, Jerzy</creatorcontrib><creatorcontrib>Heczko, Piotr B</creatorcontrib><title>Necrotising enterocolitis in preterm infants: epidemiology and antibiotic consumption in the Polish neonatology network neonatal intensive care units in 2009</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The aim of this study was to describe the epidemiology of necrotising enterocolitis (NEC), antibiotic consumption and the usefulness of microbiological tests in very low birth weight (VLBW) Polish newborns.
Prospective surveillance was performed in the year 2009 by local infection control teams. The study covered 910 infants hospitalized in six Polish neonatal intensive care units. Two kinds of indicators were used for the description of antibiotic usage: the duration of treatment (days of treatment, DOTs) and the defined daily dose (DDD).
NEC incidence was 8.7% and fatality rate was 19%. Chorioamnionitis, late gestational age and low birth weight were identified as risk factors for NEC. Catheterization, mechanical ventilation and other selected procedures were used considerably longer in newborns with NEC than in the remaining neonates. Total usage of antibiotics reached 2.9 DDDs or 1.437 days; the average use of drugs per case of NEC amounted to 0.47 DDD or 23.2 DOTs. The level of antibiotic usage was analysed with correlation to microbiological tests performed and it was non-significantly greater in the group of children with NEC in whom the tests were performed.
A high risk of developing NEC is closely associated with VLBW and with inflammation of the amnion during labour. We observed no relationship between the consumption of antibiotics in neonates with NEC and positive results of microbiological testing indicating sepsis accompanying NEC or gut colonization with pathogens.</description><subject>Amnion</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Babies</subject><subject>Bioethics</subject><subject>Birth weight</subject><subject>Catheterization</subject><subject>Children</subject><subject>Chorioamnionitis</subject><subject>Colonization</subject><subject>Consumption</subject><subject>Correlation analysis</subject><subject>Dosage</subject><subject>Drugs</subject><subject>Enterocolitis</subject><subject>Enterocolitis, Necrotizing - diagnosis</subject><subject>Enterocolitis, Necrotizing - drug therapy</subject><subject>Enterocolitis, Necrotizing - epidemiology</subject><subject>Enterocolitis, Necrotizing - microbiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gastrointestinal diseases</subject><subject>Gestational age</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - drug therapy</subject><subject>Infant, Premature, Diseases - epidemiology</subject><subject>Infants</subject><subject>Infection</subject><subject>Infection control</subject><subject>Infections</subject><subject>Intensive care</subject><subject>Intensive care units</subject><subject>Intensive Care Units, Neonatal</subject><subject>Low birth weight</subject><subject>Male</subject><subject>Mechanical properties</subject><subject>Mechanical ventilation</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Microbiology</subject><subject>Necrosis</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Pathogenesis</subject><subject>Pathogens</subject><subject>Patient Outcome Assessment</subject><subject>Pediatrics</subject><subject>Poland</subject><subject>Premature babies</subject><subject>Premature infants</subject><subject>Prospective Studies</subject><subject>Public Health Surveillance</subject><subject>Research and Analysis Methods</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Sepsis</subject><subject>Studies</subject><subject>Surveillance</subject><subject>Systematic 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wójkowska-Mach, Jadwiga</au><au>Różańska, Anna</au><au>Borszewska-Kornacka, Maria</au><au>Domańska, Joanna</au><au>Gadzinowski, Janusz</au><au>Gulczyńska, Ewa</au><au>Helwich, Ewa</au><au>Kordek, Agnieszka</au><au>Pawlik, Dorota</au><au>Szczapa, Jerzy</au><au>Heczko, Piotr B</au><au>Rogers, Lynette K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Necrotising enterocolitis in preterm infants: epidemiology and antibiotic consumption in the Polish neonatology network neonatal intensive care units in 2009</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-03-21</date><risdate>2014</risdate><volume>9</volume><issue>3</issue><spage>e92865</spage><epage>e92865</epage><pages>e92865-e92865</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The aim of this study was to describe the epidemiology of necrotising enterocolitis (NEC), antibiotic consumption and the usefulness of microbiological tests in very low birth weight (VLBW) Polish newborns.
Prospective surveillance was performed in the year 2009 by local infection control teams. The study covered 910 infants hospitalized in six Polish neonatal intensive care units. Two kinds of indicators were used for the description of antibiotic usage: the duration of treatment (days of treatment, DOTs) and the defined daily dose (DDD).
NEC incidence was 8.7% and fatality rate was 19%. Chorioamnionitis, late gestational age and low birth weight were identified as risk factors for NEC. Catheterization, mechanical ventilation and other selected procedures were used considerably longer in newborns with NEC than in the remaining neonates. Total usage of antibiotics reached 2.9 DDDs or 1.437 days; the average use of drugs per case of NEC amounted to 0.47 DDD or 23.2 DOTs. The level of antibiotic usage was analysed with correlation to microbiological tests performed and it was non-significantly greater in the group of children with NEC in whom the tests were performed.
A high risk of developing NEC is closely associated with VLBW and with inflammation of the amnion during labour. We observed no relationship between the consumption of antibiotics in neonates with NEC and positive results of microbiological testing indicating sepsis accompanying NEC or gut colonization with pathogens.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24658445</pmid><doi>10.1371/journal.pone.0092865</doi><tpages>e92865</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-03, Vol.9 (3), p.e92865-e92865 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1509205630 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Amnion Anti-Bacterial Agents - therapeutic use Antibiotics Babies Bioethics Birth weight Catheterization Children Chorioamnionitis Colonization Consumption Correlation analysis Dosage Drugs Enterocolitis Enterocolitis, Necrotizing - diagnosis Enterocolitis, Necrotizing - drug therapy Enterocolitis, Necrotizing - epidemiology Enterocolitis, Necrotizing - microbiology Epidemiology Female Gastrointestinal diseases Gestational age Health aspects Hospitals Humans Incidence Infant, Newborn Infant, Premature Infant, Premature, Diseases - drug therapy Infant, Premature, Diseases - epidemiology Infants Infection Infection control Infections Intensive care Intensive care units Intensive Care Units, Neonatal Low birth weight Male Mechanical properties Mechanical ventilation Medical research Medicine and Health Sciences Microbiology Necrosis Neonates Newborn babies Pathogenesis Pathogens Patient Outcome Assessment Pediatrics Poland Premature babies Premature infants Prospective Studies Public Health Surveillance Research and Analysis Methods Risk analysis Risk Factors Sepsis Studies Surveillance Systematic review Ventilation |
| title | Necrotising enterocolitis in preterm infants: epidemiology and antibiotic consumption in the Polish neonatology network neonatal intensive care units in 2009 |
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