Either non-homologous ends joining or homologous recombination is required to repair double-strand breaks in the genome of macrophage-internalized Mycobacterium tuberculosis

The intracellular pathogen Mycobacterium tuberculosis (Mtb) is constantly exposed to a multitude of hostile conditions and is confronted by a variety of potentially DNA-damaging assaults in vivo, primarily from host-generated antimicrobial toxic radicals. Exposure to reactive nitrogen species and/or...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92799
Hauptverfasser:	Brzostek, Anna, Szulc, Izabela, Klink, Magdalena, Brzezinska, Marta, Sulowska, Zofia, Dziadek, Jaroslaw
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial agents Bacilli Biocompatibility Biology Biology and Life Sciences Biotechnology Cell death Cell Line Cell survival Complementation Cytotoxicity Damage Deamination Defects Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded - radiation effects DNA damage DNA End-Joining Repair DNA methylation DNA repair Free radicals Gene Order Genes Genetic aspects Genome, Bacterial Genomes Genomics Homologous Recombination Homology Humans Infections Ionizing radiation Macrophages Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Medicine and Health Sciences Methylation Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - radiation effects Nitric oxide Nitric Oxide - biosynthesis Non-homologous end joining Oxidation Oxygen Pathogenesis Phagocytosis - immunology Reactive nitrogen species Reactive oxygen species Reactive Oxygen Species - metabolism Rec A Recombinases - metabolism RecA protein Repair Superoxide Survival Tuberculosis Ultraviolet Rays
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