Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy: TIM-3/galectin-9 interaction and its possible role during pregnancy

The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the Galectin-9/TIM-3 pathway as an important negative regula...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92371-e92371
Hauptverfasser:	Meggyes, Matyas, Miko, Eva, Polgar, Beata, Bogar, Barbara, Farkas, Balint, Illes, Zsolt, Szereday, Laszlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Biology and life sciences Blood CD56 Antigen - metabolism CD8 antigen CD8-Positive T-Lymphocytes - metabolism Cytokines Cytokines - biosynthesis Cytometry Cytotoxicity Cytotoxicity, Immunologic - immunology Down-Regulation Endocrinology Enzyme-linked immunosorbent assay Female Fetuses Flow cytometry Galectin-9 Galectins - blood Galectins - metabolism Hepatitis A Virus Cellular Receptor 2 Humans Hypotheses Immune system Immunity Immunoglobulins Immunological tolerance Immunology Immunoregulation Inflammation Mediators - metabolism Killer cells Killer Cells, Natural - metabolism Leukocytes (mononuclear) Ligands Lymphocytes Lymphocytes T Lysosomal-Associated Membrane Protein 1 - metabolism Medicine and Health Sciences Membrane Proteins - blood Metabolism Middle Aged Molecular structure Mucin Natural killer cells Pathogenesis Peripheral blood mononuclear cells Phenotype Pregnancy Pregnant women Protein Binding Research and Analysis Methods T cell receptors T cells Toxicity Women's health Womens health
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