Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity

Atsttrin, a progranulin (PGRN)-derived molecule composed of three TNFR-binding domains of PGRN, binds to TNF receptors (TNFR) and is therapeutic against inflammatory arthritis. Here we screened the associations of Atsttrin and other members in TNFR subfamily, which led to the discovery of TNFRSF25 (...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92743
Hauptverfasser:	Liu, Cui, Li, Xing-Xia, Gao, Wei, Liu, Wen, Liu, De-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Alzheimers disease Animals Arthritis Autoimmune diseases Biocompatibility Biology and Life Sciences Biomedical materials Body Weight - drug effects Cell Line Cloning Colitis Colitis - chemically induced Colitis - metabolism Colitis - pathology Cysteine - chemistry Cytokines Dextran Dextran sulfate Dextran Sulfate - adverse effects Disease Models, Animal Dose-Response Relationship, Drug Hemorrhage - prevention & control Hospitals Inflammation Ligands Macrophages - metabolism Medicine and Health Sciences Mice Multigene Family Osteoclastogenesis Pediatrics Protein Binding - drug effects Protein Interaction Domains and Motifs Proteins Receptors Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - metabolism Receptors, Tumor Necrosis Factor, Member 25 - chemistry Receptors, Tumor Necrosis Factor, Member 25 - genetics Receptors, Tumor Necrosis Factor, Member 25 - metabolism Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Rheumatoid arthritis Rodents Sodium Sulfates Tumor necrosis factor Tumor Necrosis Factor Ligand Superfamily Member 15 - antagonists & inhibitors Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism Tumor necrosis factor receptors Tumor necrosis factor-TNF Yeast
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