Need for supplemental oxygen at discharge in infants with bronchopulmonary dysplasia is not associated with worse neurodevelopmental outcomes at 3 years corrected age
To determine if chronic oxygen dependency (discharge home on supplemental oxygen) in children with bronchopulmonary dysplasia (BPD; defined as requirement for supplemental O2 at 36 weeks postmenstrual age) predicts neurodevelopmental disability rates and growth outcomes at 36 months corrected age (C...
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| Veröffentlicht in: | PloS one 2014-03, Vol.9 (3), p.e90843-e90843 |
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| creator | Lodha, Abhay Sauvé, Reg Bhandari, Vineet Tang, Selphee Christianson, Heather Bhandari, Anita Amin, Harish Singhal, Nalini |
| description | To determine if chronic oxygen dependency (discharge home on supplemental oxygen) in children with bronchopulmonary dysplasia (BPD; defined as requirement for supplemental O2 at 36 weeks postmenstrual age) predicts neurodevelopmental disability rates and growth outcomes at 36 months corrected age (CA).
Longitudinal cohort study.
Southern Alberta regional center located at high altitude.
Preterm infants weighing ≤1250 grams with no BPD, BPD, and BPD with chronic oxygen dependency.
Neurodevelopmental and growth outcomes.
Of 1563 preterm infants admitted from 1995-2007, 1212 survived. Complete follow-up data were available for 1030 (85%) children. Children in BPD and BPD with chronic oxygen dependency groups had significantly lower birth weights, gestational ages, prolonged mechanical ventilation and oxygen supplementation and received more postnatal steroids, compared to those without BPD. Children with BPD and BPD with chronic oxygen dependency were more likely to be below the 5th centile in weight and height compared to those without BPD but there was little difference between the BPD and BPD with chronic oxygen dependency groups. After controlling for confounding variables, children who had BPD and BPD with chronic oxygen dependency had higher odds of neurodevelopmental disability compared to those without BPD [OR (odds ratio) 1.9 (95%CI 1.1 to 3.5) and OR 1.8 (1.1 to 2.9), respectively], with no significant difference between BPD and BPD with chronic oxygen dependency [OR 0.9 (95% CI 0.6 to 1.5)].
BPD and BPD with chronic oxygen dependency in children predicts abnormal neurodevelopmental outcomes at 36 months CA. However, the neurodevelopmental disability rates were not significantly higher in BPD with chronic oxygen dependency children compared to children with BPD only. Compared to those without BPD, growth is impaired in children with BPD and BPD with chronic oxygen dependency, but no difference between the latter two groups. |
| doi_str_mv | 10.1371/journal.pone.0090843 |
| format | Article |
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Longitudinal cohort study.
Southern Alberta regional center located at high altitude.
Preterm infants weighing ≤1250 grams with no BPD, BPD, and BPD with chronic oxygen dependency.
Neurodevelopmental and growth outcomes.
Of 1563 preterm infants admitted from 1995-2007, 1212 survived. Complete follow-up data were available for 1030 (85%) children. Children in BPD and BPD with chronic oxygen dependency groups had significantly lower birth weights, gestational ages, prolonged mechanical ventilation and oxygen supplementation and received more postnatal steroids, compared to those without BPD. Children with BPD and BPD with chronic oxygen dependency were more likely to be below the 5th centile in weight and height compared to those without BPD but there was little difference between the BPD and BPD with chronic oxygen dependency groups. After controlling for confounding variables, children who had BPD and BPD with chronic oxygen dependency had higher odds of neurodevelopmental disability compared to those without BPD [OR (odds ratio) 1.9 (95%CI 1.1 to 3.5) and OR 1.8 (1.1 to 2.9), respectively], with no significant difference between BPD and BPD with chronic oxygen dependency [OR 0.9 (95% CI 0.6 to 1.5)].
BPD and BPD with chronic oxygen dependency in children predicts abnormal neurodevelopmental outcomes at 36 months CA. However, the neurodevelopmental disability rates were not significantly higher in BPD with chronic oxygen dependency children compared to children with BPD only. Compared to those without BPD, growth is impaired in children with BPD and BPD with chronic oxygen dependency, but no difference between the latter two groups.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0090843</identifier><identifier>PMID: 24646665</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Biology and Life Sciences ; Birth weight ; Bronchopulmonary dysplasia ; Bronchopulmonary Dysplasia - complications ; Bronchopulmonary Dysplasia - physiopathology ; Bronchopulmonary Dysplasia - therapy ; Child, Preschool ; Children ; Children & youth ; Developmental Disabilities - etiology ; Developmental Disabilities - physiopathology ; Developmental Disabilities - therapy ; Discharge ; Dysplasia ; Female ; Gestational Age ; Health sciences ; Health services ; High altitude ; High-altitude environments ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Infants ; Intensive care ; Longitudinal Studies ; Lung diseases ; Male ; Maternal & child health ; Mechanical ventilation ; Medicine and Health Sciences ; Neurodevelopmental disorders ; Newborn babies ; Obstetrics ; Oxygen ; Oxygen - pharmacology ; Oxygen therapy ; Patient Discharge ; Pediatrics ; Premature infants ; Prognosis ; Research and Analysis Methods ; Respiration, Artificial ; Respiratory Insufficiency - complications ; Respiratory Insufficiency - physiopathology ; Respiratory Insufficiency - therapy ; Respiratory therapy ; Steroid hormones ; Steroids ; Supplementation ; Supplements ; Ultrasonic imaging ; Ventilation ; Ventilators</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e90843-e90843</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Lodha et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Lodha et al 2014 Lodha et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d0b67995efbfc87618fad3d0bdacf897accbfa11470f04db231d84f632791bb73</citedby><cites>FETCH-LOGICAL-c692t-d0b67995efbfc87618fad3d0bdacf897accbfa11470f04db231d84f632791bb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960119/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960119/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24646665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lavoie, Pascal</contributor><creatorcontrib>Lodha, Abhay</creatorcontrib><creatorcontrib>Sauvé, Reg</creatorcontrib><creatorcontrib>Bhandari, Vineet</creatorcontrib><creatorcontrib>Tang, Selphee</creatorcontrib><creatorcontrib>Christianson, Heather</creatorcontrib><creatorcontrib>Bhandari, Anita</creatorcontrib><creatorcontrib>Amin, Harish</creatorcontrib><creatorcontrib>Singhal, Nalini</creatorcontrib><title>Need for supplemental oxygen at discharge in infants with bronchopulmonary dysplasia is not associated with worse neurodevelopmental outcomes at 3 years corrected age</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine if chronic oxygen dependency (discharge home on supplemental oxygen) in children with bronchopulmonary dysplasia (BPD; defined as requirement for supplemental O2 at 36 weeks postmenstrual age) predicts neurodevelopmental disability rates and growth outcomes at 36 months corrected age (CA).
Longitudinal cohort study.
Southern Alberta regional center located at high altitude.
Preterm infants weighing ≤1250 grams with no BPD, BPD, and BPD with chronic oxygen dependency.
Neurodevelopmental and growth outcomes.
Of 1563 preterm infants admitted from 1995-2007, 1212 survived. Complete follow-up data were available for 1030 (85%) children. Children in BPD and BPD with chronic oxygen dependency groups had significantly lower birth weights, gestational ages, prolonged mechanical ventilation and oxygen supplementation and received more postnatal steroids, compared to those without BPD. Children with BPD and BPD with chronic oxygen dependency were more likely to be below the 5th centile in weight and height compared to those without BPD but there was little difference between the BPD and BPD with chronic oxygen dependency groups. After controlling for confounding variables, children who had BPD and BPD with chronic oxygen dependency had higher odds of neurodevelopmental disability compared to those without BPD [OR (odds ratio) 1.9 (95%CI 1.1 to 3.5) and OR 1.8 (1.1 to 2.9), respectively], with no significant difference between BPD and BPD with chronic oxygen dependency [OR 0.9 (95% CI 0.6 to 1.5)].
BPD and BPD with chronic oxygen dependency in children predicts abnormal neurodevelopmental outcomes at 36 months CA. However, the neurodevelopmental disability rates were not significantly higher in BPD with chronic oxygen dependency children compared to children with BPD only. Compared to those without BPD, growth is impaired in children with BPD and BPD with chronic oxygen dependency, but no difference between the latter two groups.</description><subject>Age</subject><subject>Biology and Life Sciences</subject><subject>Birth weight</subject><subject>Bronchopulmonary dysplasia</subject><subject>Bronchopulmonary Dysplasia - complications</subject><subject>Bronchopulmonary Dysplasia - physiopathology</subject><subject>Bronchopulmonary Dysplasia - therapy</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Developmental Disabilities - etiology</subject><subject>Developmental Disabilities - physiopathology</subject><subject>Developmental Disabilities - therapy</subject><subject>Discharge</subject><subject>Dysplasia</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Health sciences</subject><subject>Health services</subject><subject>High altitude</subject><subject>High-altitude environments</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Very Low Birth Weight</subject><subject>Infants</subject><subject>Intensive care</subject><subject>Longitudinal Studies</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Maternal & child health</subject><subject>Mechanical ventilation</subject><subject>Medicine and Health Sciences</subject><subject>Neurodevelopmental disorders</subject><subject>Newborn babies</subject><subject>Obstetrics</subject><subject>Oxygen</subject><subject>Oxygen - pharmacology</subject><subject>Oxygen therapy</subject><subject>Patient Discharge</subject><subject>Pediatrics</subject><subject>Premature infants</subject><subject>Prognosis</subject><subject>Research and Analysis Methods</subject><subject>Respiration, Artificial</subject><subject>Respiratory Insufficiency - complications</subject><subject>Respiratory Insufficiency - physiopathology</subject><subject>Respiratory Insufficiency - therapy</subject><subject>Respiratory therapy</subject><subject>Steroid hormones</subject><subject>Steroids</subject><subject>Supplementation</subject><subject>Supplements</subject><subject>Ultrasonic imaging</subject><subject>Ventilation</subject><subject>Ventilators</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tq3DAQhk1padJt36C0gkJpL3YrWT7eFELoYSE00NOtGEtjr4MsOZKcZF-oz1k52YRsyUWxwWb8_f94ZjRJ8pLRFeMl-3BmJ2dAr0ZrcEVpTauMP0oOWc3TZZFS_vje-0HyzPszSnNeFcXT5CDNiqwoivww-fMNUZHWOuKncdQ4oAmgib3admgIBKJ6LzfgOiS9iXcLJnhy2YcNaZw1cmPHSQ_WgNsStfWjBt8D6T0xNhDw3soeQsxwrbi0ziMxODmr8AK1HW_TTUHaAf2ckJMtgvNEWudQzlro8HnypAXt8cXuuUh-ff708_jr8uT0y_r46GQpizoNS0WboqzrHNumlVVZsKoFxWNUgWyrugQpmxYYy0ra0kw1KWeqytqCp2XNmqbki-T1je-orRe7FnvBchrd8jplkVjfEMrCmRhdP8TShYVeXAes6wS40EuNAtqcScUzlLzJKkarNM3SChvO61ypEqLXx122qRlQydgMB3rPdP-L6TeisxeC1wVlcbqL5N3OwNnzCX0QQxwXag0G7XT933U2n5a5sjf_oA9Xt6M6iAXEcduYV86m4igrqzKvyiyP1OoBKl4Kh17G89j2Mb4neL8niEzAq9DB5L1Y__j-_-zp73327T12g6DDxls9hd4avw9mN6B01nuH7V2TGRVzg267IeZ1Ert1irJX9wd0J7rdH_4Xi6cfxA</recordid><startdate>20140319</startdate><enddate>20140319</enddate><creator>Lodha, Abhay</creator><creator>Sauvé, Reg</creator><creator>Bhandari, Vineet</creator><creator>Tang, Selphee</creator><creator>Christianson, Heather</creator><creator>Bhandari, Anita</creator><creator>Amin, Harish</creator><creator>Singhal, Nalini</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140319</creationdate><title>Need for supplemental oxygen at discharge in infants with bronchopulmonary dysplasia is not associated with worse neurodevelopmental outcomes at 3 years corrected age</title><author>Lodha, Abhay ; Sauvé, Reg ; Bhandari, Vineet ; Tang, Selphee ; Christianson, Heather ; Bhandari, Anita ; Amin, Harish ; Singhal, Nalini</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-d0b67995efbfc87618fad3d0bdacf897accbfa11470f04db231d84f632791bb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age</topic><topic>Biology and Life Sciences</topic><topic>Birth weight</topic><topic>Bronchopulmonary dysplasia</topic><topic>Bronchopulmonary Dysplasia - complications</topic><topic>Bronchopulmonary Dysplasia - physiopathology</topic><topic>Bronchopulmonary Dysplasia - therapy</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Developmental Disabilities - etiology</topic><topic>Developmental Disabilities - physiopathology</topic><topic>Developmental Disabilities - therapy</topic><topic>Discharge</topic><topic>Dysplasia</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Health sciences</topic><topic>Health services</topic><topic>High altitude</topic><topic>High-altitude environments</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Very Low Birth Weight</topic><topic>Infants</topic><topic>Intensive care</topic><topic>Longitudinal Studies</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Maternal & child health</topic><topic>Mechanical ventilation</topic><topic>Medicine and Health Sciences</topic><topic>Neurodevelopmental disorders</topic><topic>Newborn babies</topic><topic>Obstetrics</topic><topic>Oxygen</topic><topic>Oxygen - pharmacology</topic><topic>Oxygen therapy</topic><topic>Patient Discharge</topic><topic>Pediatrics</topic><topic>Premature infants</topic><topic>Prognosis</topic><topic>Research and Analysis Methods</topic><topic>Respiration, Artificial</topic><topic>Respiratory Insufficiency - complications</topic><topic>Respiratory Insufficiency - physiopathology</topic><topic>Respiratory Insufficiency - therapy</topic><topic>Respiratory therapy</topic><topic>Steroid hormones</topic><topic>Steroids</topic><topic>Supplementation</topic><topic>Supplements</topic><topic>Ultrasonic imaging</topic><topic>Ventilation</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lodha, Abhay</creatorcontrib><creatorcontrib>Sauvé, Reg</creatorcontrib><creatorcontrib>Bhandari, Vineet</creatorcontrib><creatorcontrib>Tang, Selphee</creatorcontrib><creatorcontrib>Christianson, Heather</creatorcontrib><creatorcontrib>Bhandari, Anita</creatorcontrib><creatorcontrib>Amin, Harish</creatorcontrib><creatorcontrib>Singhal, Nalini</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lodha, Abhay</au><au>Sauvé, Reg</au><au>Bhandari, Vineet</au><au>Tang, Selphee</au><au>Christianson, Heather</au><au>Bhandari, Anita</au><au>Amin, Harish</au><au>Singhal, Nalini</au><au>Lavoie, Pascal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Need for supplemental oxygen at discharge in infants with bronchopulmonary dysplasia is not associated with worse neurodevelopmental outcomes at 3 years corrected age</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-03-19</date><risdate>2014</risdate><volume>9</volume><issue>3</issue><spage>e90843</spage><epage>e90843</epage><pages>e90843-e90843</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To determine if chronic oxygen dependency (discharge home on supplemental oxygen) in children with bronchopulmonary dysplasia (BPD; defined as requirement for supplemental O2 at 36 weeks postmenstrual age) predicts neurodevelopmental disability rates and growth outcomes at 36 months corrected age (CA).
Longitudinal cohort study.
Southern Alberta regional center located at high altitude.
Preterm infants weighing ≤1250 grams with no BPD, BPD, and BPD with chronic oxygen dependency.
Neurodevelopmental and growth outcomes.
Of 1563 preterm infants admitted from 1995-2007, 1212 survived. Complete follow-up data were available for 1030 (85%) children. Children in BPD and BPD with chronic oxygen dependency groups had significantly lower birth weights, gestational ages, prolonged mechanical ventilation and oxygen supplementation and received more postnatal steroids, compared to those without BPD. Children with BPD and BPD with chronic oxygen dependency were more likely to be below the 5th centile in weight and height compared to those without BPD but there was little difference between the BPD and BPD with chronic oxygen dependency groups. After controlling for confounding variables, children who had BPD and BPD with chronic oxygen dependency had higher odds of neurodevelopmental disability compared to those without BPD [OR (odds ratio) 1.9 (95%CI 1.1 to 3.5) and OR 1.8 (1.1 to 2.9), respectively], with no significant difference between BPD and BPD with chronic oxygen dependency [OR 0.9 (95% CI 0.6 to 1.5)].
BPD and BPD with chronic oxygen dependency in children predicts abnormal neurodevelopmental outcomes at 36 months CA. However, the neurodevelopmental disability rates were not significantly higher in BPD with chronic oxygen dependency children compared to children with BPD only. Compared to those without BPD, growth is impaired in children with BPD and BPD with chronic oxygen dependency, but no difference between the latter two groups.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24646665</pmid><doi>10.1371/journal.pone.0090843</doi><tpages>e90843</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-03, Vol.9 (3), p.e90843-e90843 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1508765921 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Biology and Life Sciences Birth weight Bronchopulmonary dysplasia Bronchopulmonary Dysplasia - complications Bronchopulmonary Dysplasia - physiopathology Bronchopulmonary Dysplasia - therapy Child, Preschool Children Children & youth Developmental Disabilities - etiology Developmental Disabilities - physiopathology Developmental Disabilities - therapy Discharge Dysplasia Female Gestational Age Health sciences Health services High altitude High-altitude environments Hospitals Humans Infant Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Infants Intensive care Longitudinal Studies Lung diseases Male Maternal & child health Mechanical ventilation Medicine and Health Sciences Neurodevelopmental disorders Newborn babies Obstetrics Oxygen Oxygen - pharmacology Oxygen therapy Patient Discharge Pediatrics Premature infants Prognosis Research and Analysis Methods Respiration, Artificial Respiratory Insufficiency - complications Respiratory Insufficiency - physiopathology Respiratory Insufficiency - therapy Respiratory therapy Steroid hormones Steroids Supplementation Supplements Ultrasonic imaging Ventilation Ventilators |
| title | Need for supplemental oxygen at discharge in infants with bronchopulmonary dysplasia is not associated with worse neurodevelopmental outcomes at 3 years corrected age |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T18%3A41%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Need%20for%20supplemental%20oxygen%20at%20discharge%20in%20infants%20with%20bronchopulmonary%20dysplasia%20is%20not%20associated%20with%20worse%20neurodevelopmental%20outcomes%20at%203%20years%20corrected%20age&rft.jtitle=PloS%20one&rft.au=Lodha,%20Abhay&rft.date=2014-03-19&rft.volume=9&rft.issue=3&rft.spage=e90843&rft.epage=e90843&rft.pages=e90843-e90843&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0090843&rft_dat=%3Cgale_plos_%3EA478758745%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1508765921&rft_id=info:pmid/24646665&rft_galeid=A478758745&rft_doaj_id=oai_doaj_org_article_af51cd34ec3b4810822428eb3395dd7a&rfr_iscdi=true |