The complex regulation of tanshinone IIA in rats with hypertension-induced left ventricular hypertrophy

Tanshinone IIA has definite protective effects on various cardiovascular diseases. However, in hypertension-induced left ventricular hypertrophy (H-LVH), the signaling pathways of tanshinone IIA in inhibition of remodeling and cardiac dysfunction remain unclear. Two-kidney, one-clip induced hyperten...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92216-e92216
Hauptverfasser:	Pang, Hui, Han, Bing, Yu, Tao, Peng, Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Abietanes - pharmacology Abietanes - therapeutic use Animal tissues Animals Apelin Apelin Receptors Apoptosis Apoptosis - drug effects Bax protein Bcl-2 protein Biology and life sciences Blood Pressure - drug effects Bone morphogenetic proteins Cardiomyocytes Cardiovascular diseases Caspase Caspase-3 Collagen - metabolism Deposition Down-regulation Echocardiography Extracellular matrix Fibroblasts Fibrosis Gelatinase A Growth factors Heart Heart diseases Heart failure Heart function Heart Function Tests Heart hypertrophy Heart Ventricles - drug effects Heart Ventricles - enzymology Heart Ventricles - pathology Heart Ventricles - physiopathology Hospitals Hypertension Hypertension - complications Hypertension - physiopathology Hypertrophy Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - drug therapy Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - physiopathology Immunohistochemistry In vivo methods and tests Intercellular Signaling Peptides and Proteins - blood Kidneys Kinases Male Malondialdehyde Malondialdehyde - metabolism Matrix metalloproteinase Matrix Metalloproteinase 2 - metabolism Matrix metalloproteinases Medicine and Health Sciences Muscle contraction Myocytes, Cardiac - drug effects Myocytes, Cardiac - pathology Oxidative stress Proteins Rats Rats, Sprague-Dawley Receptors, G-Protein-Coupled - metabolism Research and Analysis Methods Risk factors Rodents Signal transduction Signaling Superoxide dismutase Superoxide Dismutase - metabolism Superoxides Systole - drug effects Tissue Inhibitor of Metalloproteinase-2 - metabolism Transforming growth factors Ultrasonography Ventricle Ventricular Remodeling - drug effects
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