Bactericidal antibiotics increase hydroxyphenyl fluorescein signal by altering cell morphology

It was recently proposed that for bactericidal antibiotics a common killing mechanism contributes to lethality involving indirect stimulation of hydroxyl radical (OH•) formation. Flow cytometric detection of OH• by hydroxyphenyl fluorescein (HPF) probe oxidation was used to support this hypothesis....

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92231-e92231
Hauptverfasser:	Paulander, Wilhelm, Wang, Ying, Folkesson, Anders, Charbon, Godefroid, Løbner-Olesen, Anders, Ingmer, Hanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotics Apoptosis Bacteria Biology Biology and Life Sciences Cell division Cell morphology Cell size Cytology E coli Elongation Escherichia coli Escherichia coli - cytology Escherichia coli - drug effects Flow Cytometry Fluorescein Fluorescein - metabolism Fluoresceins - metabolism Fluorescence Green fluorescent protein Green Fluorescent Proteins - metabolism Hydroxyl radicals Hypotheses Killing Lethality Metabolism Metabolites Microscopy Microscopy, Interference Morphology Oxidation Oxygen Physiological aspects Proteins Reactive oxygen species Research and Analysis Methods Science
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