HY immune tolerance is common in women without male offspring

Sex difference is an established risk factor for hematopoietic stem cell transplantation (HSCT)-related complications like graft versus host disease (GVHD). CD8pos cytotoxic T cells specific for Y chromosome-encoded minor Histocompatibility antigens (HY) play an important role therein. Prior to HSC...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e91274-e91274
Hauptverfasser:	Dierselhuis, Miranda P, Jankowska-Gan, Ewa, Blokland, Els, Pool, Jos, Burlingham, William J, van Halteren, Astrid G S, Goulmy, Els
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Analysis Animals Antigen-antibody reactions Antigens Biology and Life Sciences Blood & organ donations Blood transfusions Chimerism Chromosomes Coding Complications Cytotoxicity Deoxyribonucleic acid DNA Female Females Gene Expression Genetics Graft-versus-host reaction Grafts H-Y Antigen - genetics H-Y Antigen - immunology Hematopoietic stem cell transplantation Hematopoietic stem cells Histocompatibility antigen HLA HLA antigens Humans Hypersensitivity Hypersensitivity (delayed) Immune response Immune Tolerance Immunological tolerance Immunoregulation Leukocytes Lymphocytes Lymphocytes T Male Medicine and Health Sciences Mice Minor histocompatibility antigens Molecular Sequence Data Obstetrics Offspring Peptides Pregnancy Pregnancy complications Priming Research and Analysis Methods Risk factors Sex Factors Stem cell transplantation Stem cells T cell receptors T cells T-Lymphocytes, Cytotoxic - chemistry T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Regulatory - chemistry T-Lymphocytes, Regulatory - immunology Transplantation Transplants & implants Women Women's health Y chromosomes
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