Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial β-barrel anion channel hVDAC-2

The anti-apoptotic 19-stranded transmembrane human voltage dependent anion channel isoform 2 (hVDAC-2) β-barrel stability is crucial for anion transport in mitochondria. The role of the unusually high number of cysteine residues in this isoform is poorly understood. Using a Cys-less construct of hVD...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92183
Hauptverfasser:	Maurya, Svetlana Rajkumar, Mahalakshmi, Radhakrishnan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Anions Apoptosis Biology and Life Sciences Biophysics Channel gating Crystallography Cysteine Cysteine - chemistry Cysteine - genetics Cystine Dimethylamines - chemistry Dynamic stability Equilibrium Escherichia coli - genetics Escherichia coli - metabolism Fluorescence Gene Expression Humans Laboratories Lipids Metabolites Micelles Mitochondria Mitochondria - chemistry Mitochondria - metabolism Models, Molecular Mutation Physical Sciences Preservation Protein Folding Protein interaction Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Stability Protein Structure, Secondary Proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Residues Rigidity Science education Thermodynamics Thiols Tryptophan - chemistry Tryptophan - genetics Voltage-Dependent Anion Channel 2 - chemistry Voltage-Dependent Anion Channel 2 - genetics Voltage-Dependent Anion Channel 2 - metabolism
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