Gene therapy for neuropathic pain by silencing of TNF-α expression with lentiviral vectors targeting the dorsal root ganglion in mice

Neuropathic pain can be a debilitating condition. Many types of drugs that have been used to treat neuropathic pain have only limited efficacy. Recent studies indicate that pro-inflammatory mediators including tumor necrosis factor α (TNF-α) are involved in the pathogenesis of neuropathic pain. In t...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92073-e92073
Hauptverfasser:	Ogawa, Nobuhiro, Kawai, Hiromichi, Terashima, Tomoya, Kojima, Hideto, Oka, Kazuhiro, Chan, Lawrence, Maegawa, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 3 Activating Transcription Factor 3 - genetics Activating Transcription Factor 3 - metabolism Animals Apoptosis Biology and Life Sciences Cell death Cell Death - genetics Cellular biology Cellulose acetate Cytomegalovirus Diabetes Diabetic neuropathy Disease Models, Animal Dorsal root ganglia Drugs Expression vectors Ganglia, Spinal - injuries Ganglia, Spinal - metabolism Gene expression Gene Expression Regulation Gene Silencing Gene therapy Genetic Therapy - methods Genetic Vectors In vivo methods and tests Inflammation Interleukin 6 Interleukin-6 - antagonists & inhibitors Interleukin-6 - genetics Interleukin-6 - metabolism Lentivirus - genetics Male Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Nervous system Neuralgia Neuralgia - genetics Neuralgia - metabolism Neuralgia - pathology Neuralgia - therapy Neurons - metabolism Neurons - pathology Neuropathy Neuropeptide Y Neuropeptide Y - antagonists & inhibitors Neuropeptide Y - genetics Neuropeptide Y - metabolism Pain Pain perception Pathogenesis Plasmids Research and Analysis Methods RNA, Messenger - antagonists & inhibitors RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Rodents Science Signal Transduction Spinal Cord Injuries Studies Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Vectors (Biology)
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