Dynamin 1 is required for memory formation
Dynamin 1-3 isoforms are known to be involved in endocytotic processes occurring during synaptic transmission. No data has directly linked dynamins yet with normal animal behavior. Here we show that dynamin pharmacologic inhibition markedly impairs hippocampal-dependent associative memory. Memory lo...
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| Veröffentlicht in: | PloS one 2014-03, Vol.9 (3), p.e91954 |
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| creator | Fà, Mauro Staniszewski, Agnieszka Saeed, Faisal Francis, Yitshak I Arancio, Ottavio |
| description | Dynamin 1-3 isoforms are known to be involved in endocytotic processes occurring during synaptic transmission. No data has directly linked dynamins yet with normal animal behavior. Here we show that dynamin pharmacologic inhibition markedly impairs hippocampal-dependent associative memory. Memory loss was associated with changes in synaptic function occurring during repetitive stimulation that is thought to be linked with memory induction. Synaptic fatigue was accentuated by dynamin inhibition. Moreover, dynamin inhibition markedly reduced long-term potentiation, post-tetanic potentiation, and neurotransmitter released during repetitive stimulation. Most importantly, the effect of dynamin inhibition onto memory and synaptic plasticity was due to a specific involvement of the dynamin 1 isoform, as demonstrated through a genetic approach with siRNA against this isoform to temporally block it. Taken together, these findings identify dynamin 1 as a key protein for modulation of memory and release evoked by repetitive activity. |
| doi_str_mv | 10.1371/journal.pone.0091954 |
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No data has directly linked dynamins yet with normal animal behavior. Here we show that dynamin pharmacologic inhibition markedly impairs hippocampal-dependent associative memory. Memory loss was associated with changes in synaptic function occurring during repetitive stimulation that is thought to be linked with memory induction. Synaptic fatigue was accentuated by dynamin inhibition. Moreover, dynamin inhibition markedly reduced long-term potentiation, post-tetanic potentiation, and neurotransmitter released during repetitive stimulation. Most importantly, the effect of dynamin inhibition onto memory and synaptic plasticity was due to a specific involvement of the dynamin 1 isoform, as demonstrated through a genetic approach with siRNA against this isoform to temporally block it. Taken together, these findings identify dynamin 1 as a key protein for modulation of memory and release evoked by repetitive activity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0091954</identifier><identifier>PMID: 24643165</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aging ; Alzheimer's disease ; Alzheimers disease ; Animal behavior ; Animals ; Associative memory ; Biology and Life Sciences ; Brain research ; Dynamin ; Dynamin I - antagonists & inhibitors ; Dynamin I - genetics ; Dynamin I - metabolism ; Electric Stimulation ; Excitatory Postsynaptic Potentials - drug effects ; Excitatory Postsynaptic Potentials - physiology ; Fatigue ; Gene Expression ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - physiology ; Hostages ; Hydrazones - pharmacology ; Inhibition ; Isoforms ; Laboratory animals ; Long-term potentiation ; Long-Term Potentiation - drug effects ; Long-Term Potentiation - physiology ; Male ; Medicine and Health Sciences ; Memory ; Memory - drug effects ; Memory - physiology ; Memory Disorders - chemically induced ; Memory Disorders - metabolism ; Memory Disorders - physiopathology ; Mice ; Mice, Inbred C57BL ; Neuronal Plasticity - drug effects ; Neuronal Plasticity - physiology ; Pharmacology ; Potentiation ; Proteins ; Refractory Period, Electrophysiological - drug effects ; Refractory Period, Electrophysiological - physiology ; RNA, Small Interfering - genetics ; RNA, Small Interfering - metabolism ; siRNA ; Social Sciences ; Stimulation ; Synapses - drug effects ; Synapses - physiology ; Synaptic plasticity ; Synaptic transmission ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e91954</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Fà et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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No data has directly linked dynamins yet with normal animal behavior. Here we show that dynamin pharmacologic inhibition markedly impairs hippocampal-dependent associative memory. Memory loss was associated with changes in synaptic function occurring during repetitive stimulation that is thought to be linked with memory induction. Synaptic fatigue was accentuated by dynamin inhibition. Moreover, dynamin inhibition markedly reduced long-term potentiation, post-tetanic potentiation, and neurotransmitter released during repetitive stimulation. Most importantly, the effect of dynamin inhibition onto memory and synaptic plasticity was due to a specific involvement of the dynamin 1 isoform, as demonstrated through a genetic approach with siRNA against this isoform to temporally block it. Taken together, these findings identify dynamin 1 as a key protein for modulation of memory and release evoked by repetitive activity.</description><subject>Aging</subject><subject>Alzheimer's disease</subject><subject>Alzheimers disease</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Associative memory</subject><subject>Biology and Life Sciences</subject><subject>Brain research</subject><subject>Dynamin</subject><subject>Dynamin I - antagonists & inhibitors</subject><subject>Dynamin I - genetics</subject><subject>Dynamin I - metabolism</subject><subject>Electric Stimulation</subject><subject>Excitatory Postsynaptic Potentials - drug effects</subject><subject>Excitatory Postsynaptic Potentials - physiology</subject><subject>Fatigue</subject><subject>Gene Expression</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Hostages</subject><subject>Hydrazones - pharmacology</subject><subject>Inhibition</subject><subject>Isoforms</subject><subject>Laboratory animals</subject><subject>Long-term potentiation</subject><subject>Long-Term Potentiation - drug effects</subject><subject>Long-Term Potentiation - physiology</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Memory</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Memory Disorders - chemically induced</subject><subject>Memory Disorders - metabolism</subject><subject>Memory Disorders - physiopathology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neuronal Plasticity - drug effects</subject><subject>Neuronal Plasticity - physiology</subject><subject>Pharmacology</subject><subject>Potentiation</subject><subject>Proteins</subject><subject>Refractory Period, Electrophysiological - drug effects</subject><subject>Refractory Period, Electrophysiological - physiology</subject><subject>RNA, Small Interfering - genetics</subject><subject>RNA, Small Interfering - metabolism</subject><subject>siRNA</subject><subject>Social Sciences</subject><subject>Stimulation</subject><subject>Synapses - 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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aging Alzheimer's disease Alzheimers disease Animal behavior Animals Associative memory Biology and Life Sciences Brain research Dynamin Dynamin I - antagonists & inhibitors Dynamin I - genetics Dynamin I - metabolism Electric Stimulation Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fatigue Gene Expression Hippocampus Hippocampus - drug effects Hippocampus - physiology Hostages Hydrazones - pharmacology Inhibition Isoforms Laboratory animals Long-term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Medicine and Health Sciences Memory Memory - drug effects Memory - physiology Memory Disorders - chemically induced Memory Disorders - metabolism Memory Disorders - physiopathology Mice Mice, Inbred C57BL Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Pharmacology Potentiation Proteins Refractory Period, Electrophysiological - drug effects Refractory Period, Electrophysiological - physiology RNA, Small Interfering - genetics RNA, Small Interfering - metabolism siRNA Social Sciences Stimulation Synapses - drug effects Synapses - physiology Synaptic plasticity Synaptic transmission Synaptic Transmission - drug effects Synaptic Transmission - physiology |
| title | Dynamin 1 is required for memory formation |
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