Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer

The HOXB13 gene has been implicated in prostate cancer (PrCa) susceptibility. We performed a high resolution fine-mapping analysis to comprehensively evaluate the association between common genetic variation across the HOXB genetic locus at 17q21 and PrCa risk. This involved genotyping 700 SNPs usin...

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Veröffentlicht in:	PLoS genetics 2014-02, Vol.10 (2), p.e1004129
Hauptverfasser:	Saunders, Edward J, Dadaev, Tokhir, Leongamornlert, Daniel A, Jugurnauth-Little, Sarah, Tymrakiewicz, Malgorzata, Wiklund, Fredrik, Al Olama, Ali Amin, Benlloch, Sara, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Giles, Graham G, Severi, Gianluca, Gronberg, Henrik, Aly, Markus, Haiman, Christopher A, Schumacher, Fredrick, Henderson, Brian E, Lindstrom, Sara, Kraft, Peter, Hunter, David J, Gapstur, Susan, Chanock, Stephen, Berndt, Sonja I, Albanes, Demetrius, Andriole, Gerald, Schleutker, Johanna, Weischer, Maren, Nordestgaard, Børge G, Canzian, Federico, Campa, Daniele, Riboli, Elio, Key, Tim J, Travis, Ruth C, Ingles, Sue A, John, Esther M, Hayes, Richard B, Pharoah, Paul, Khaw, Kay-Tee, Stanford, Janet L, Ostrander, Elaine A, Signorello, Lisa B, Thibodeau, Stephen N, Schaid, Daniel, Maier, Christiane, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong Y, Kaneva, Radka, Batra, Jyotsna, Clements, Judith A, Teixeira, Manuel R, Xu, Jianfeng, Mikropoulos, Christos, Goh, Chee, Govindasami, Koveela, Guy, Michelle, Wilkinson, Rosemary A, Sawyer, Emma J, Morgan, Angela, Easton, Douglas F, Muir, Ken, Eeles, Rosalind A, Kote-Jarai, Zsofia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Analysis Biology Chromosomes, Human, Pair 17 - genetics Demographic aspects Disease Genes Genetic aspects Genetic Predisposition to Disease Genetic Variation Genome-Wide Association Study Genotype Haplotypes Homeodomain Proteins - genetics Humans Male Medical research Mortality Patient outcomes Polymorphism, Single Nucleotide Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Risk Factors Studies Tumors
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