Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection

Mycobacterium tuberculosis is an intracellular pathogen. Within macrophages, M. tuberculosis thrives in a specialized membrane-bound vacuole, the phagosome, whose pH is slightly acidic, and where access to nutrients is limited. Understanding how the bacillus extracts and incorporates nutrients from...

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Veröffentlicht in:	PLoS pathogens 2014-02, Vol.10 (2), p.e1003928-e1003928
Hauptverfasser:	Gouzy, Alexandre, Larrouy-Maumus, Gérald, Bottai, Daria, Levillain, Florence, Dumas, Alexia, Wallach, Joshua B, Caire-Brandli, Irène, de Chastellier, Chantal, Wu, Ting-Di, Poincloux, Renaud, Brosch, Roland, Guerquin-Kern, Jean-Luc, Schnappinger, Dirk, Sório de Carvalho, Luiz Pedro, Poquet, Yannick, Neyrolles, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asparagine - metabolism Biology Carbon Care and treatment Chromatography, Liquid Complications and side effects Development and progression Disease Models, Animal Experiments Female Flow Cytometry Gene Knockout Techniques Hydrolysis Immunoblotting Infections Macrophages - microbiology Mass Spectrometry Membrane Transport Proteins - metabolism Mice Mice, Inbred C57BL Microscopy Microscopy, Confocal Microscopy, Immunoelectron Mycobacterium tuberculosis - metabolism Nitrogen - metabolism Patient outcomes Phagosomes - metabolism Phagosomes - microbiology Risk factors Stress, Physiological Tuberculosis Tuberculosis - metabolism
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