A BMP-FGF morphogen toggle switch drives the ultrasensitive expression of multiple genes in the developing forebrain

Borders are important as they demarcate developing tissue into distinct functional units. A key challenge is the discovery of mechanisms that can convert morphogen gradients into tissue borders. While mechanisms that produce ultrasensitive cellular responses provide a solution, how extracellular mor...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS computational biology 2014-02, Vol.10 (2), p.e1003463
Hauptverfasser:	Srinivasan, Shyam, Hu, Jia Sheng, Currle, D Spencer, Fung, Ernest S, Hayes, Wayne B, Lander, Arthur D, Monuki, Edwin S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biology Bone Morphogenetic Protein 4 - metabolism Bone Morphogenetic Protein 4 - pharmacology Bone morphogenetic proteins Bone Morphogenetic Proteins - metabolism Bone Morphogenetic Proteins - pharmacology Computational Biology Computer Science Embryo Culture Techniques Experiments Feedback, Physiological Female Fibroblast growth factors Fibroblast Growth Factors - metabolism Fibroblast Growth Factors - pharmacology Gene expression Gene Expression Regulation, Developmental - drug effects Genes Health aspects Kinases Mathematical models Mathematics Medical research Mice Mice, Transgenic Models, Biological Morphogenesis MSX1 Transcription Factor - genetics Physics Pregnancy Prosencephalon - drug effects Prosencephalon - embryology Prosencephalon - metabolism Receptors, Fibroblast Growth Factor - antagonists & inhibitors Signal Transduction Telencephalon - drug effects Telencephalon - embryology Telencephalon - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!