Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- and Rab8-dependent and recycling endosome-independent

The intermediate conductance, Ca2+-activated K+ channel (KCa3.1) targets to the basolateral (BL) membrane in polarized epithelia where it plays a key role in transepithelial ion transport. However, there are no studies defining the anterograde and retrograde trafficking of KCa3.1 in polarized epithe...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e92013
Hauptverfasser:	Bertuccio, Claudia A, Lee, Shih-Liang, Wu, Guangyu, Butterworth, Michael B, Hamilton, Kirk L, Devor, Daniel C
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Adenoviruses Animals Anterograde transport Antibodies Biology Biology and Life Sciences Biotin Calcium conductance Calcium ions Cell Line Cell Membrane - metabolism Cell Polarity Cell surface Cells Degradation Dogs Endocytosis Endoplasmic Reticulum - metabolism Endosomes Endosomes - metabolism Epithelial Cells - cytology Epithelial Cells - metabolism Epithelium Golgi apparatus Golgi Apparatus - metabolism Humans Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism Ion transport Ligases Medical research Medicine and Health Sciences Membrane trafficking Membranes Peptides Physiology Plasma Potassium channels (calcium-gated) Potassium conductance Protein Transport Protein turnover Proteins rab GTP-Binding Proteins - metabolism rab1 GTP-Binding Proteins - metabolism Retrograde transport Trafficking Transcription factors Ubiquitin Ubiquitination
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