Association of MASP-2 levels and MASP2 gene polymorphisms with rheumatoid arthritis in patients and their relatives
Mannan-binding lectin-associated serine protease 2 (MASP-2) is a key protein of the lectin pathway of complement. MASP-2 levels have been associated with different polymorphisms within MASP2 gene as well as with the risk for inflammatory disorders and infections. Despite its clinical importance, MAS...
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| Veröffentlicht in: | PloS one 2014-03, Vol.9 (3), p.e90979-e90979 |
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| description | Mannan-binding lectin-associated serine protease 2 (MASP-2) is a key protein of the lectin pathway of complement. MASP-2 levels have been associated with different polymorphisms within MASP2 gene as well as with the risk for inflammatory disorders and infections. Despite its clinical importance, MASP-2 remains poorly investigated in rheumatoid arthritis (RA).
In this case-control study, we measured MASP-2 serum levels in 156 RA patients, 44 patient relatives, and 100 controls from Southern Brazil, associating the results with nine MASP2 polymorphisms in all patients, 111 relatives, and 230 controls genotyped with multiplex SSP-PCR.
MASP-2 levels were lower in patients than in controls and relatives (medians 181 vs. 340 or 285 ng/ml, respectively, P |
| doi_str_mv | 10.1371/journal.pone.0090979 |
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In this case-control study, we measured MASP-2 serum levels in 156 RA patients, 44 patient relatives, and 100 controls from Southern Brazil, associating the results with nine MASP2 polymorphisms in all patients, 111 relatives, and 230 controls genotyped with multiplex SSP-PCR.
MASP-2 levels were lower in patients than in controls and relatives (medians 181 vs. 340 or 285 ng/ml, respectively, P<0.0001). Conversely, high MASP-2 levels were associated with lower susceptibility to RA and to articular symptoms independently of age, gender, ethnicity, smoking habit, anti-CCP and rheumatoid factor positivity (OR = 0.05 [95%CI = 0.019-0.13], P<0.0001 between patients and controls; OR = 0.12, [95%CI = 0.03-0.45], P = 0.002 between patients and relatives; OR = 0.06, [95%CI = 0.004-0.73], P = 0.03 between relatives with and without articular symptoms). MASP2 haplotypes *2A1 and *2B1-i were associated with increased susceptibility to RA (OR = 3.32 [95%CI = 1.48-7.45], P = 0.004). Deficiency-causing p.120G and p.439H substitutions were associated with five times increased susceptibility to articular symptoms in relatives (OR = 5.13 [95%CI = 1.36-20.84], P = 0.02). There was no association of MASP-2 levels or MASP2 polymorphisms with autoantibodies, Sjögren's syndrome, nodules and functional class.
In this study, we found the first evidence that MASP-2 deficiency might play an important role in the development of RA and articular symptoms among relatives of RA patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0090979</identifier><identifier>PMID: 24632598</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Antigens ; Arthritis ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - metabolism ; Arthritis, Rheumatoid - pathology ; Autoantibodies ; Autoimmunity ; Biology and Life Sciences ; Case-Control Studies ; Control methods ; Disease ; Ethics ; Evangelicalism ; Female ; Gene expression ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease - genetics ; Genotype ; Haplotypes ; Health aspects ; Health risks ; Hospitals ; Humans ; Inflammatory diseases ; Lectins ; Male ; Mannan ; Mannose-binding lectin ; Mannose-Binding Protein-Associated Serine Proteases - genetics ; Mannose-Binding Protein-Associated Serine Proteases - metabolism ; MASP-2 protein ; MASP2 gene ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Minority & ethnic groups ; Multiplexing ; Nodules ; Pathology ; Patients ; Pediatrics ; Polymorphism, Genetic - genetics ; Population ; Proteins ; Rheumatoid arthritis ; Rheumatoid factor ; Rheumatology ; Risk factors ; Serine ; Serine proteinase ; Serum levels ; Sjogren's syndrome ; Smoking ; Studies ; Thrombin ; Young Adult</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e90979-e90979</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Goeldner et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Goeldner et al 2014 Goeldner et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d534e15d2b52e215c97218289d6c7a5b8804da563e331026fb2ca9d09e6cfd693</citedby><cites>FETCH-LOGICAL-c692t-d534e15d2b52e215c97218289d6c7a5b8804da563e331026fb2ca9d09e6cfd693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954616/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954616/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24632598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fang, Deyu</contributor><creatorcontrib>Goeldner, Isabela</creatorcontrib><creatorcontrib>Skare, Thelma</creatorcontrib><creatorcontrib>Boldt, Angelica B W</creatorcontrib><creatorcontrib>Nass, Flavia R</creatorcontrib><creatorcontrib>Messias-Reason, Iara J</creatorcontrib><creatorcontrib>Utiyama, Shirley R</creatorcontrib><title>Association of MASP-2 levels and MASP2 gene polymorphisms with rheumatoid arthritis in patients and their relatives</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Mannan-binding lectin-associated serine protease 2 (MASP-2) is a key protein of the lectin pathway of complement. MASP-2 levels have been associated with different polymorphisms within MASP2 gene as well as with the risk for inflammatory disorders and infections. Despite its clinical importance, MASP-2 remains poorly investigated in rheumatoid arthritis (RA).
In this case-control study, we measured MASP-2 serum levels in 156 RA patients, 44 patient relatives, and 100 controls from Southern Brazil, associating the results with nine MASP2 polymorphisms in all patients, 111 relatives, and 230 controls genotyped with multiplex SSP-PCR.
MASP-2 levels were lower in patients than in controls and relatives (medians 181 vs. 340 or 285 ng/ml, respectively, P<0.0001). Conversely, high MASP-2 levels were associated with lower susceptibility to RA and to articular symptoms independently of age, gender, ethnicity, smoking habit, anti-CCP and rheumatoid factor positivity (OR = 0.05 [95%CI = 0.019-0.13], P<0.0001 between patients and controls; OR = 0.12, [95%CI = 0.03-0.45], P = 0.002 between patients and relatives; OR = 0.06, [95%CI = 0.004-0.73], P = 0.03 between relatives with and without articular symptoms). MASP2 haplotypes *2A1 and *2B1-i were associated with increased susceptibility to RA (OR = 3.32 [95%CI = 1.48-7.45], P = 0.004). Deficiency-causing p.120G and p.439H substitutions were associated with five times increased susceptibility to articular symptoms in relatives (OR = 5.13 [95%CI = 1.36-20.84], P = 0.02). There was no association of MASP-2 levels or MASP2 polymorphisms with autoantibodies, Sjögren's syndrome, nodules and functional class.
In this study, we found the first evidence that MASP-2 deficiency might play an important role in the development of RA and articular symptoms among relatives of RA patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens</subject><subject>Arthritis</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Autoantibodies</subject><subject>Autoimmunity</subject><subject>Biology and Life Sciences</subject><subject>Case-Control Studies</subject><subject>Control methods</subject><subject>Disease</subject><subject>Ethics</subject><subject>Evangelicalism</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Inflammatory diseases</subject><subject>Lectins</subject><subject>Male</subject><subject>Mannan</subject><subject>Mannose-binding lectin</subject><subject>Mannose-Binding Protein-Associated Serine Proteases - genetics</subject><subject>Mannose-Binding Protein-Associated Serine Proteases - metabolism</subject><subject>MASP-2 protein</subject><subject>MASP2 gene</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Multiplexing</subject><subject>Nodules</subject><subject>Pathology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Population</subject><subject>Proteins</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Rheumatology</subject><subject>Risk factors</subject><subject>Serine</subject><subject>Serine proteinase</subject><subject>Serum levels</subject><subject>Sjogren's syndrome</subject><subject>Smoking</subject><subject>Studies</subject><subject>Thrombin</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99v0zAQxyMEYmPwHyCwhITgocWxYyd-QaomflQaGmLAq-Xal8aTEwc7Key_x22zqUV7QH6wdf7c93x3vix7nuN5Tsv83bUfQ6fcvPcdzDEWWJTiQXaaC0pmnGD68OB8kj2J8RpjRivOH2cnpOCUMFGdZnERo9dWDdZ3yNfoy-Lq64wgBxtwEanO7CwEraED1Ht30_rQNza2Ef22Q4NCA2OrBm8NUmFogh1sRLZDfVKEbthLDA3YgAK4ZNxAfJo9qpWL8Gzaz7IfHz98P_88u7j8tDxfXMw0F2SYGUYLyJkhK0aA5EyLkuQVqYThulRsVVW4MIpxCpTmmPB6RbQSBgvgujZc0LPs5V63dz7KqV5R5gyXTDAqaCKWe8J4dS37YFsVbqRXVu4MPqxlyspqBzI3TFGNBWHYFCtCK0NrxYygBgMri22091O0cdWC0Sn7oNyR6PFNZxu59htJBSt4zpPAm0kg-F8jxEG2NmpwTnXgx927qyJ1DuOEvvoHvT-7iVqrlIDtap_i6q2oXBRlVXKKeZWo-T1UWgZaq9Pnqm2yHzm8PXJIzAB_hrUaY5TLq2__z17-PGZfH7ANKDc00btx-zXjMVjsQR18jAHquyLnWG5n47YacjsbcpqN5PbisEF3TrfDQP8CrzYJLw</recordid><startdate>20140314</startdate><enddate>20140314</enddate><creator>Goeldner, Isabela</creator><creator>Skare, Thelma</creator><creator>Boldt, Angelica B W</creator><creator>Nass, Flavia R</creator><creator>Messias-Reason, Iara J</creator><creator>Utiyama, Shirley R</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140314</creationdate><title>Association of MASP-2 levels and MASP2 gene polymorphisms with rheumatoid arthritis in patients and their relatives</title><author>Goeldner, Isabela ; Skare, Thelma ; Boldt, Angelica B W ; Nass, Flavia R ; Messias-Reason, Iara J ; Utiyama, Shirley R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-d534e15d2b52e215c97218289d6c7a5b8804da563e331026fb2ca9d09e6cfd693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens</topic><topic>Arthritis</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Autoantibodies</topic><topic>Autoimmunity</topic><topic>Biology and Life Sciences</topic><topic>Case-Control Studies</topic><topic>Control methods</topic><topic>Disease</topic><topic>Ethics</topic><topic>Evangelicalism</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Inflammatory diseases</topic><topic>Lectins</topic><topic>Male</topic><topic>Mannan</topic><topic>Mannose-binding lectin</topic><topic>Mannose-Binding Protein-Associated Serine Proteases - genetics</topic><topic>Mannose-Binding Protein-Associated Serine Proteases - metabolism</topic><topic>MASP-2 protein</topic><topic>MASP2 gene</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>Multiplexing</topic><topic>Nodules</topic><topic>Pathology</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Population</topic><topic>Proteins</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Rheumatology</topic><topic>Risk factors</topic><topic>Serine</topic><topic>Serine proteinase</topic><topic>Serum levels</topic><topic>Sjogren's syndrome</topic><topic>Smoking</topic><topic>Studies</topic><topic>Thrombin</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goeldner, Isabela</creatorcontrib><creatorcontrib>Skare, Thelma</creatorcontrib><creatorcontrib>Boldt, Angelica B W</creatorcontrib><creatorcontrib>Nass, Flavia R</creatorcontrib><creatorcontrib>Messias-Reason, Iara J</creatorcontrib><creatorcontrib>Utiyama, Shirley R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goeldner, Isabela</au><au>Skare, Thelma</au><au>Boldt, Angelica B W</au><au>Nass, Flavia R</au><au>Messias-Reason, Iara J</au><au>Utiyama, Shirley R</au><au>Fang, Deyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of MASP-2 levels and MASP2 gene polymorphisms with rheumatoid arthritis in patients and their relatives</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-03-14</date><risdate>2014</risdate><volume>9</volume><issue>3</issue><spage>e90979</spage><epage>e90979</epage><pages>e90979-e90979</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Mannan-binding lectin-associated serine protease 2 (MASP-2) is a key protein of the lectin pathway of complement. MASP-2 levels have been associated with different polymorphisms within MASP2 gene as well as with the risk for inflammatory disorders and infections. Despite its clinical importance, MASP-2 remains poorly investigated in rheumatoid arthritis (RA).
In this case-control study, we measured MASP-2 serum levels in 156 RA patients, 44 patient relatives, and 100 controls from Southern Brazil, associating the results with nine MASP2 polymorphisms in all patients, 111 relatives, and 230 controls genotyped with multiplex SSP-PCR.
MASP-2 levels were lower in patients than in controls and relatives (medians 181 vs. 340 or 285 ng/ml, respectively, P<0.0001). Conversely, high MASP-2 levels were associated with lower susceptibility to RA and to articular symptoms independently of age, gender, ethnicity, smoking habit, anti-CCP and rheumatoid factor positivity (OR = 0.05 [95%CI = 0.019-0.13], P<0.0001 between patients and controls; OR = 0.12, [95%CI = 0.03-0.45], P = 0.002 between patients and relatives; OR = 0.06, [95%CI = 0.004-0.73], P = 0.03 between relatives with and without articular symptoms). MASP2 haplotypes *2A1 and *2B1-i were associated with increased susceptibility to RA (OR = 3.32 [95%CI = 1.48-7.45], P = 0.004). Deficiency-causing p.120G and p.439H substitutions were associated with five times increased susceptibility to articular symptoms in relatives (OR = 5.13 [95%CI = 1.36-20.84], P = 0.02). There was no association of MASP-2 levels or MASP2 polymorphisms with autoantibodies, Sjögren's syndrome, nodules and functional class.
In this study, we found the first evidence that MASP-2 deficiency might play an important role in the development of RA and articular symptoms among relatives of RA patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24632598</pmid><doi>10.1371/journal.pone.0090979</doi><tpages>e90979</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1507595393 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Antigens Arthritis Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Autoantibodies Autoimmunity Biology and Life Sciences Case-Control Studies Control methods Disease Ethics Evangelicalism Female Gene expression Genes Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease - genetics Genotype Haplotypes Health aspects Health risks Hospitals Humans Inflammatory diseases Lectins Male Mannan Mannose-binding lectin Mannose-Binding Protein-Associated Serine Proteases - genetics Mannose-Binding Protein-Associated Serine Proteases - metabolism MASP-2 protein MASP2 gene Medical research Medicine and Health Sciences Middle Aged Minority & ethnic groups Multiplexing Nodules Pathology Patients Pediatrics Polymorphism, Genetic - genetics Population Proteins Rheumatoid arthritis Rheumatoid factor Rheumatology Risk factors Serine Serine proteinase Serum levels Sjogren's syndrome Smoking Studies Thrombin Young Adult |
| title | Association of MASP-2 levels and MASP2 gene polymorphisms with rheumatoid arthritis in patients and their relatives |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T16%3A59%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20MASP-2%20levels%20and%20MASP2%20gene%20polymorphisms%20with%20rheumatoid%20arthritis%20in%20patients%20and%20their%20relatives&rft.jtitle=PloS%20one&rft.au=Goeldner,%20Isabela&rft.date=2014-03-14&rft.volume=9&rft.issue=3&rft.spage=e90979&rft.epage=e90979&rft.pages=e90979-e90979&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0090979&rft_dat=%3Cgale_plos_%3EA478763068%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1507595393&rft_id=info:pmid/24632598&rft_galeid=A478763068&rft_doaj_id=oai_doaj_org_article_1d5a3c09250d4b238d3fa5d93d0e5749&rfr_iscdi=true |