YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients

YAP is a key component of the Hippo signaling pathway and plays a critical role in the development and progression of multiple cancer types, including ovarian cancer. However, the effects of YAP on ovarian cancer development in vivo and its downstream effectors remain uncertain. In this study we fou...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e91770
Hauptverfasser:	Xia, Yan, Chang, Ting, Wang, Yingmei, Liu, Yixiong, Li, Wenhui, Li, Ming, Fan, Heng-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Apoptosis - drug effects Biology Cancer Cancer research Cancer therapies Carcinogenesis - drug effects Cell cycle Cell growth Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Cell proliferation Cell Proliferation - drug effects Cell Transformation, Neoplastic Chemotherapy Cisplatin - pharmacology DNA-Binding Proteins - metabolism Drug resistance Drug Resistance, Neoplasm Drugs Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Humans In vivo methods and tests Kinases Laboratory animals Life sciences Liver cancer Medical prognosis Medicine Mesenchyme Mice Muscle Proteins - metabolism Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - diagnosis Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Paclitaxel - pharmacology Pathology Patients Phosphoproteins - metabolism Phosphorylation Prognosis Proteins Signal transduction Signaling Survival Transcription factors Transcription Factors - metabolism Tumorigenesis Tumors Yes-associated protein
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