Brain activity of adolescents with high functioning autism in response to emotional words and facial emoticons
Studies of social dysfunction in patients with autism spectrum disorder (ASD) have generally focused on the perception of emotional words and facial affect. Brain imaging studies have suggested that the fusiform gyrus is associated with both the comprehension of language and face recognition. We hyp...
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| Veröffentlicht in: | PloS one 2014-03, Vol.9 (3), p.e91214-e91214 |
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| description | Studies of social dysfunction in patients with autism spectrum disorder (ASD) have generally focused on the perception of emotional words and facial affect. Brain imaging studies have suggested that the fusiform gyrus is associated with both the comprehension of language and face recognition. We hypothesized that patients with ASD would have decreased ability to recognize affect via emotional words and facial emoticons, relative to healthy comparison subjects. In addition, we expected that this decreased ability would be associated with altered activity of the fusiform gyrus in patients with ASD. Ten male adolescents with ASDs and ten age and sex matched healthy comparison subjects were enrolled in this case-control study. The diagnosis of autism was further evaluated with the Autism Diagnostic Observation Schedule. Brain activity was assessed using functional magnetic resonance imaging (fMRI) in response to emotional words and facial emoticon presentation. Sixty emotional words (45 pleasant words +15 unpleasant words) were extracted from a report on Korean emotional terms and their underlying dimensions. Sixty emoticon faces (45 pleasant faces +15 unpleasant faces) were extracted and modified from on-line sites. Relative to healthy comparison subjects, patients with ASD have increased activation of fusiform gyrus in response to emotional aspects of words. In contrast, patients with ASD have decreased activation of fusiform gyrus in response to facial emoticons, relative to healthy comparison subjects. We suggest that patients with ASD are more familiar with word descriptions than facial expression as depictions of emotion. |
| doi_str_mv | 10.1371/journal.pone.0091214 |
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Brain imaging studies have suggested that the fusiform gyrus is associated with both the comprehension of language and face recognition. We hypothesized that patients with ASD would have decreased ability to recognize affect via emotional words and facial emoticons, relative to healthy comparison subjects. In addition, we expected that this decreased ability would be associated with altered activity of the fusiform gyrus in patients with ASD. Ten male adolescents with ASDs and ten age and sex matched healthy comparison subjects were enrolled in this case-control study. The diagnosis of autism was further evaluated with the Autism Diagnostic Observation Schedule. Brain activity was assessed using functional magnetic resonance imaging (fMRI) in response to emotional words and facial emoticon presentation. Sixty emotional words (45 pleasant words +15 unpleasant words) were extracted from a report on Korean emotional terms and their underlying dimensions. Sixty emoticon faces (45 pleasant faces +15 unpleasant faces) were extracted and modified from on-line sites. Relative to healthy comparison subjects, patients with ASD have increased activation of fusiform gyrus in response to emotional aspects of words. In contrast, patients with ASD have decreased activation of fusiform gyrus in response to facial emoticons, relative to healthy comparison subjects. We suggest that patients with ASD are more familiar with word descriptions than facial expression as depictions of emotion.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0091214</identifier><identifier>PMID: 24621866</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activation ; Adolescent ; Adolescents ; Affect ; Attentional bias ; Autism ; Biology ; Biometry ; Brain ; Brain - physiopathology ; Brain mapping ; Cardiac patients ; Case-Control Studies ; Child Development Disorders, Pervasive - physiopathology ; Cluster Analysis ; Diagnostic systems ; Emotional icons ; Emotions ; Face recognition ; Facial Expression ; Functional magnetic resonance imaging ; Humans ; Magnetic resonance ; Magnetic Resonance Imaging ; Male ; Medical research ; Medicine ; Neuroimaging ; Patients ; Pattern recognition ; Social and Behavioral Sciences ; Surveys and Questionnaires ; Teenagers ; Youth</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e91214-e91214</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Han et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Han et al 2014 Han et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-2f89a70e46b186e482d2104920f4af747e4b728913ccd9e91fdef29f1637d6183</citedby><cites>FETCH-LOGICAL-c692t-2f89a70e46b186e482d2104920f4af747e4b728913ccd9e91fdef29f1637d6183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951306/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951306/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24621866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hampson, Michelle</contributor><creatorcontrib>Han, Doug Hyun</creatorcontrib><creatorcontrib>Yoo, Hee Jeong</creatorcontrib><creatorcontrib>Kim, Bung Nyun</creatorcontrib><creatorcontrib>McMahon, William</creatorcontrib><creatorcontrib>Renshaw, Perry F</creatorcontrib><title>Brain activity of adolescents with high functioning autism in response to emotional words and facial emoticons</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Studies of social dysfunction in patients with autism spectrum disorder (ASD) have generally focused on the perception of emotional words and facial affect. Brain imaging studies have suggested that the fusiform gyrus is associated with both the comprehension of language and face recognition. We hypothesized that patients with ASD would have decreased ability to recognize affect via emotional words and facial emoticons, relative to healthy comparison subjects. In addition, we expected that this decreased ability would be associated with altered activity of the fusiform gyrus in patients with ASD. Ten male adolescents with ASDs and ten age and sex matched healthy comparison subjects were enrolled in this case-control study. The diagnosis of autism was further evaluated with the Autism Diagnostic Observation Schedule. Brain activity was assessed using functional magnetic resonance imaging (fMRI) in response to emotional words and facial emoticon presentation. Sixty emotional words (45 pleasant words +15 unpleasant words) were extracted from a report on Korean emotional terms and their underlying dimensions. Sixty emoticon faces (45 pleasant faces +15 unpleasant faces) were extracted and modified from on-line sites. Relative to healthy comparison subjects, patients with ASD have increased activation of fusiform gyrus in response to emotional aspects of words. In contrast, patients with ASD have decreased activation of fusiform gyrus in response to facial emoticons, relative to healthy comparison subjects. We suggest that patients with ASD are more familiar with word descriptions than facial expression as depictions of emotion.</description><subject>Activation</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Affect</subject><subject>Attentional bias</subject><subject>Autism</subject><subject>Biology</subject><subject>Biometry</subject><subject>Brain</subject><subject>Brain - physiopathology</subject><subject>Brain mapping</subject><subject>Cardiac patients</subject><subject>Case-Control Studies</subject><subject>Child Development Disorders, Pervasive - physiopathology</subject><subject>Cluster Analysis</subject><subject>Diagnostic systems</subject><subject>Emotional icons</subject><subject>Emotions</subject><subject>Face recognition</subject><subject>Facial Expression</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance 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Brain imaging studies have suggested that the fusiform gyrus is associated with both the comprehension of language and face recognition. We hypothesized that patients with ASD would have decreased ability to recognize affect via emotional words and facial emoticons, relative to healthy comparison subjects. In addition, we expected that this decreased ability would be associated with altered activity of the fusiform gyrus in patients with ASD. Ten male adolescents with ASDs and ten age and sex matched healthy comparison subjects were enrolled in this case-control study. The diagnosis of autism was further evaluated with the Autism Diagnostic Observation Schedule. Brain activity was assessed using functional magnetic resonance imaging (fMRI) in response to emotional words and facial emoticon presentation. Sixty emotional words (45 pleasant words +15 unpleasant words) were extracted from a report on Korean emotional terms and their underlying dimensions. Sixty emoticon faces (45 pleasant faces +15 unpleasant faces) were extracted and modified from on-line sites. Relative to healthy comparison subjects, patients with ASD have increased activation of fusiform gyrus in response to emotional aspects of words. In contrast, patients with ASD have decreased activation of fusiform gyrus in response to facial emoticons, relative to healthy comparison subjects. We suggest that patients with ASD are more familiar with word descriptions than facial expression as depictions of emotion.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24621866</pmid><doi>10.1371/journal.pone.0091214</doi><tpages>e91214</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Activation Adolescent Adolescents Affect Attentional bias Autism Biology Biometry Brain Brain - physiopathology Brain mapping Cardiac patients Case-Control Studies Child Development Disorders, Pervasive - physiopathology Cluster Analysis Diagnostic systems Emotional icons Emotions Face recognition Facial Expression Functional magnetic resonance imaging Humans Magnetic resonance Magnetic Resonance Imaging Male Medical research Medicine Neuroimaging Patients Pattern recognition Social and Behavioral Sciences Surveys and Questionnaires Teenagers Youth |
| title | Brain activity of adolescents with high functioning autism in response to emotional words and facial emoticons |
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