Hip fractures and bone mineral density in the elderly--importance of serum 25-hydroxyvitamin D
The significance of serum 25-hydroxyvitamin D [25(OH)D] concentrations for hip fracture risk of the elderly is still uncertain. Difficulties reaching both frail and healthy elderly people in randomized controlled trials or large cohort studies may in part explain discordant findings. We determined h...
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| creator | Steingrimsdottir, Laufey Halldorsson, Thorhallur I Siggeirsdottir, Kristin Cotch, Mary Frances Einarsdottir, Berglind O Eiriksdottir, Gudny Sigurdsson, Sigurdur Launer, Lenore J Harris, Tamara B Gudnason, Vilmundur Sigurdsson, Gunnar |
| description | The significance of serum 25-hydroxyvitamin D [25(OH)D] concentrations for hip fracture risk of the elderly is still uncertain. Difficulties reaching both frail and healthy elderly people in randomized controlled trials or large cohort studies may in part explain discordant findings. We determined hazard ratios for hip fractures of elderly men and women related to serum 25(OH)D, including both the frail and the healthy segment of the elderly population.
The AGES-Reykjavik Study is a prospective study of 5764 men and women, age 66-96 years, based on a representative sample of the population of Reykjavik, Iceland. Participation was 71.8%. Hazard ratios of incident hip fractures and baseline bone mineral density were determined according to serum concentrations of 25(OH)D at baseline.
Mean follow-up was 5.4 years. Compared with referent values (50-75 nmol/L), hazard ratios for hip fractures were 2.24 (95% CI 1.63, 3.09) for serum 25(OH)D |
| doi_str_mv | 10.1371/journal.pone.0091122 |
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The AGES-Reykjavik Study is a prospective study of 5764 men and women, age 66-96 years, based on a representative sample of the population of Reykjavik, Iceland. Participation was 71.8%. Hazard ratios of incident hip fractures and baseline bone mineral density were determined according to serum concentrations of 25(OH)D at baseline.
Mean follow-up was 5.4 years. Compared with referent values (50-75 nmol/L), hazard ratios for hip fractures were 2.24 (95% CI 1.63, 3.09) for serum 25(OH)D <30 nmol/L, adjusting for age, sex, body mass index, height, smoking, alcohol intake and season, and 2.08 (95% CI 1.51, 2.87), adjusting additionally for physical activity. No difference in risk was associated with 30-50 nmol/L or ≥75 nmol/L in either model compared with referent. Analyzing the sexes separately, hazard ratios were 2.61 (95% CI 1.47, 4.64) in men and 1.93 (95% CI 1.31, 2.84) in women. Values <30 nmol/L were associated with significantly lower bone mineral density of femoral neck compared with referent, z-scores -0.14 (95% CI -0.27, -0.00) in men and -0.11 (95% CI -0.22, -0.01) in women.
Our results lend support to the overarching importance of maintaining serum 25(OH)D above 30 nmol/L for bone health of elderly people while potential benefits of having much higher levels could not be detected.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0091122</identifier><identifier>PMID: 24621578</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aged, 80 and over ; Alcohol use ; Analysis ; Bone Density ; Exercise ; Female ; Follow-Up Studies ; Frail Elderly ; Hip fractures ; Hip Fractures - blood ; Hip Fractures - epidemiology ; Hip Fractures - physiopathology ; Humans ; Male ; Mathematics ; Medicine ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e91122-e91122</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Steingrimsdottir et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Steingrimsdottir et al 2014 Steingrimsdottir et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-d88b3f83bf6ad9a44fe79197f5a148c22668034545f9c8a72a34b73110d6f4ac3</citedby><cites>FETCH-LOGICAL-c758t-d88b3f83bf6ad9a44fe79197f5a148c22668034545f9c8a72a34b73110d6f4ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951316/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951316/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24621578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>He, Bin</contributor><creatorcontrib>Steingrimsdottir, Laufey</creatorcontrib><creatorcontrib>Halldorsson, Thorhallur I</creatorcontrib><creatorcontrib>Siggeirsdottir, Kristin</creatorcontrib><creatorcontrib>Cotch, Mary Frances</creatorcontrib><creatorcontrib>Einarsdottir, Berglind O</creatorcontrib><creatorcontrib>Eiriksdottir, Gudny</creatorcontrib><creatorcontrib>Sigurdsson, Sigurdur</creatorcontrib><creatorcontrib>Launer, Lenore J</creatorcontrib><creatorcontrib>Harris, Tamara B</creatorcontrib><creatorcontrib>Gudnason, Vilmundur</creatorcontrib><creatorcontrib>Sigurdsson, Gunnar</creatorcontrib><title>Hip fractures and bone mineral density in the elderly--importance of serum 25-hydroxyvitamin D</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The significance of serum 25-hydroxyvitamin D [25(OH)D] concentrations for hip fracture risk of the elderly is still uncertain. Difficulties reaching both frail and healthy elderly people in randomized controlled trials or large cohort studies may in part explain discordant findings. We determined hazard ratios for hip fractures of elderly men and women related to serum 25(OH)D, including both the frail and the healthy segment of the elderly population.
The AGES-Reykjavik Study is a prospective study of 5764 men and women, age 66-96 years, based on a representative sample of the population of Reykjavik, Iceland. Participation was 71.8%. Hazard ratios of incident hip fractures and baseline bone mineral density were determined according to serum concentrations of 25(OH)D at baseline.
Mean follow-up was 5.4 years. Compared with referent values (50-75 nmol/L), hazard ratios for hip fractures were 2.24 (95% CI 1.63, 3.09) for serum 25(OH)D <30 nmol/L, adjusting for age, sex, body mass index, height, smoking, alcohol intake and season, and 2.08 (95% CI 1.51, 2.87), adjusting additionally for physical activity. No difference in risk was associated with 30-50 nmol/L or ≥75 nmol/L in either model compared with referent. Analyzing the sexes separately, hazard ratios were 2.61 (95% CI 1.47, 4.64) in men and 1.93 (95% CI 1.31, 2.84) in women. Values <30 nmol/L were associated with significantly lower bone mineral density of femoral neck compared with referent, z-scores -0.14 (95% CI -0.27, -0.00) in men and -0.11 (95% CI -0.22, -0.01) in women.
Our results lend support to the overarching importance of maintaining serum 25(OH)D above 30 nmol/L for bone health of elderly people while potential benefits of having much higher levels could not be detected.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alcohol use</subject><subject>Analysis</subject><subject>Bone Density</subject><subject>Exercise</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Frail Elderly</subject><subject>Hip fractures</subject><subject>Hip Fractures - blood</subject><subject>Hip Fractures - epidemiology</subject><subject>Hip Fractures - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Mathematics</subject><subject>Medicine</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - 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fractures and bone mineral density in the elderly--importance of serum 25-hydroxyvitamin D</title><author>Steingrimsdottir, Laufey ; Halldorsson, Thorhallur I ; Siggeirsdottir, Kristin ; Cotch, Mary Frances ; Einarsdottir, Berglind O ; Eiriksdottir, Gudny ; Sigurdsson, Sigurdur ; Launer, Lenore J ; Harris, Tamara B ; Gudnason, Vilmundur ; Sigurdsson, Gunnar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-d88b3f83bf6ad9a44fe79197f5a148c22668034545f9c8a72a34b73110d6f4ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alcohol use</topic><topic>Analysis</topic><topic>Bone Density</topic><topic>Exercise</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Frail Elderly</topic><topic>Hip fractures</topic><topic>Hip Fractures - blood</topic><topic>Hip Fractures - epidemiology</topic><topic>Hip Fractures - 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Vilmundur</au><au>Sigurdsson, Gunnar</au><au>He, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hip fractures and bone mineral density in the elderly--importance of serum 25-hydroxyvitamin D</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-03-12</date><risdate>2014</risdate><volume>9</volume><issue>3</issue><spage>e91122</spage><epage>e91122</epage><pages>e91122-e91122</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The significance of serum 25-hydroxyvitamin D [25(OH)D] concentrations for hip fracture risk of the elderly is still uncertain. Difficulties reaching both frail and healthy elderly people in randomized controlled trials or large cohort studies may in part explain discordant findings. We determined hazard ratios for hip fractures of elderly men and women related to serum 25(OH)D, including both the frail and the healthy segment of the elderly population.
The AGES-Reykjavik Study is a prospective study of 5764 men and women, age 66-96 years, based on a representative sample of the population of Reykjavik, Iceland. Participation was 71.8%. Hazard ratios of incident hip fractures and baseline bone mineral density were determined according to serum concentrations of 25(OH)D at baseline.
Mean follow-up was 5.4 years. Compared with referent values (50-75 nmol/L), hazard ratios for hip fractures were 2.24 (95% CI 1.63, 3.09) for serum 25(OH)D <30 nmol/L, adjusting for age, sex, body mass index, height, smoking, alcohol intake and season, and 2.08 (95% CI 1.51, 2.87), adjusting additionally for physical activity. No difference in risk was associated with 30-50 nmol/L or ≥75 nmol/L in either model compared with referent. Analyzing the sexes separately, hazard ratios were 2.61 (95% CI 1.47, 4.64) in men and 1.93 (95% CI 1.31, 2.84) in women. Values <30 nmol/L were associated with significantly lower bone mineral density of femoral neck compared with referent, z-scores -0.14 (95% CI -0.27, -0.00) in men and -0.11 (95% CI -0.22, -0.01) in women.
Our results lend support to the overarching importance of maintaining serum 25(OH)D above 30 nmol/L for bone health of elderly people while potential benefits of having much higher levels could not be detected.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24621578</pmid><doi>10.1371/journal.pone.0091122</doi><tpages>e91122</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-03, Vol.9 (3), p.e91122-e91122 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1506819328 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Aged, 80 and over Alcohol use Analysis Bone Density Exercise Female Follow-Up Studies Frail Elderly Hip fractures Hip Fractures - blood Hip Fractures - epidemiology Hip Fractures - physiopathology Humans Male Mathematics Medicine Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Hip fractures and bone mineral density in the elderly--importance of serum 25-hydroxyvitamin D |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T07%3A35%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hip%20fractures%20and%20bone%20mineral%20density%20in%20the%20elderly--importance%20of%20serum%2025-hydroxyvitamin%20D&rft.jtitle=PloS%20one&rft.au=Steingrimsdottir,%20Laufey&rft.date=2014-03-12&rft.volume=9&rft.issue=3&rft.spage=e91122&rft.epage=e91122&rft.pages=e91122-e91122&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0091122&rft_dat=%3Cgale_plos_%3EA478770300%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1506819328&rft_id=info:pmid/24621578&rft_galeid=A478770300&rft_doaj_id=oai_doaj_org_article_bae2f613ed6c410e8c0d5ea7045e1f6f&rfr_iscdi=true |