An integrated multi-omics study revealed metabolic alterations underlying the effects of coffee consumption
Many epidemiological studies have indicated that coffee consumption may reduce the risks of developing obesity and diabetes, but the underlying mechanisms of these effects are poorly understood. Our previous study revealed the changes on gene expression profiles in the livers of C57BL/6J mice fed a...
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| creator | Takahashi, Shoko Saito, Kenji Jia, Huijuan Kato, Hisanori |
| description | Many epidemiological studies have indicated that coffee consumption may reduce the risks of developing obesity and diabetes, but the underlying mechanisms of these effects are poorly understood. Our previous study revealed the changes on gene expression profiles in the livers of C57BL/6J mice fed a high-fat diet containing three types of coffee (caffeinated, decaffeinated and green unroasted coffee), using DNA microarrays. The results revealed remarkable alterations in lipid metabolism-related molecules which may be involved in the anti-obesity effects of coffee. We conducted the present study to further elucidate the metabolic alterations underlying the effects of coffee consumption through comprehensive proteomic and metabolomic analyses. Proteomics revealed an up-regulation of isocitrate dehydrogenase (a key enzyme in the TCA cycle) and its related proteins, suggesting increased energy generation. The metabolomics showed an up-regulation of metabolites involved in the urea cycle, with which the transcriptome data were highly consistent, indicating accelerated energy expenditure. The TCA cycle and the urea cycle are likely be accelerated in a concerted manner, since they are directly connected by mutually providing each other's intermediates. The up-regulation of these pathways might result in a metabolic shift causing increased ATP turnover, which is related to the alterations of lipid metabolism. This mechanism may play an important part in the suppressive effects of coffee consumption on obesity, inflammation, and hepatosteatosis. This study newly revealed global metabolic alterations induced by coffee intake, providing significant insights into the association between coffee intake and the prevention of type 2 diabetes, utilizing the benefits of multi-omics analyses. |
| doi_str_mv | 10.1371/journal.pone.0091134 |
| format | Article |
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Our previous study revealed the changes on gene expression profiles in the livers of C57BL/6J mice fed a high-fat diet containing three types of coffee (caffeinated, decaffeinated and green unroasted coffee), using DNA microarrays. The results revealed remarkable alterations in lipid metabolism-related molecules which may be involved in the anti-obesity effects of coffee. We conducted the present study to further elucidate the metabolic alterations underlying the effects of coffee consumption through comprehensive proteomic and metabolomic analyses. Proteomics revealed an up-regulation of isocitrate dehydrogenase (a key enzyme in the TCA cycle) and its related proteins, suggesting increased energy generation. The metabolomics showed an up-regulation of metabolites involved in the urea cycle, with which the transcriptome data were highly consistent, indicating accelerated energy expenditure. The TCA cycle and the urea cycle are likely be accelerated in a concerted manner, since they are directly connected by mutually providing each other's intermediates. The up-regulation of these pathways might result in a metabolic shift causing increased ATP turnover, which is related to the alterations of lipid metabolism. This mechanism may play an important part in the suppressive effects of coffee consumption on obesity, inflammation, and hepatosteatosis. This study newly revealed global metabolic alterations induced by coffee intake, providing significant insights into the association between coffee intake and the prevention of type 2 diabetes, utilizing the benefits of multi-omics analyses.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0091134</identifier><identifier>PMID: 24618914</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Biology ; Coffee ; Consumption ; Deoxyribonucleic acid ; Development and progression ; Diabetes mellitus ; DNA ; DNA microarrays ; Drinking Behavior ; Energy expenditure ; Epidemiology ; Gene expression ; Gene Expression Profiling ; Health risks ; High fat diet ; Intermediates ; Isocitrate dehydrogenase ; Lipid metabolism ; Liver - metabolism ; Male ; Medicine ; Metabolic Networks and Pathways ; Metabolism ; Metabolites ; Metabolome ; Metabolomics ; Metabolomics - methods ; Mice ; Models, Animal ; Obesity ; Proteins ; Proteome ; Proteomics ; Risk reduction ; Tricarboxylic acid cycle ; Type 2 diabetes ; Urea ; Urea - metabolism</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e91134-e91134</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Takahashi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Our previous study revealed the changes on gene expression profiles in the livers of C57BL/6J mice fed a high-fat diet containing three types of coffee (caffeinated, decaffeinated and green unroasted coffee), using DNA microarrays. The results revealed remarkable alterations in lipid metabolism-related molecules which may be involved in the anti-obesity effects of coffee. We conducted the present study to further elucidate the metabolic alterations underlying the effects of coffee consumption through comprehensive proteomic and metabolomic analyses. Proteomics revealed an up-regulation of isocitrate dehydrogenase (a key enzyme in the TCA cycle) and its related proteins, suggesting increased energy generation. The metabolomics showed an up-regulation of metabolites involved in the urea cycle, with which the transcriptome data were highly consistent, indicating accelerated energy expenditure. The TCA cycle and the urea cycle are likely be accelerated in a concerted manner, since they are directly connected by mutually providing each other's intermediates. The up-regulation of these pathways might result in a metabolic shift causing increased ATP turnover, which is related to the alterations of lipid metabolism. This mechanism may play an important part in the suppressive effects of coffee consumption on obesity, inflammation, and hepatosteatosis. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Shoko</au><au>Saito, Kenji</au><au>Jia, Huijuan</au><au>Kato, Hisanori</au><au>Chowen, Julie A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An integrated multi-omics study revealed metabolic alterations underlying the effects of coffee consumption</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-03-11</date><risdate>2014</risdate><volume>9</volume><issue>3</issue><spage>e91134</spage><epage>e91134</epage><pages>e91134-e91134</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Many epidemiological studies have indicated that coffee consumption may reduce the risks of developing obesity and diabetes, but the underlying mechanisms of these effects are poorly understood. Our previous study revealed the changes on gene expression profiles in the livers of C57BL/6J mice fed a high-fat diet containing three types of coffee (caffeinated, decaffeinated and green unroasted coffee), using DNA microarrays. The results revealed remarkable alterations in lipid metabolism-related molecules which may be involved in the anti-obesity effects of coffee. We conducted the present study to further elucidate the metabolic alterations underlying the effects of coffee consumption through comprehensive proteomic and metabolomic analyses. Proteomics revealed an up-regulation of isocitrate dehydrogenase (a key enzyme in the TCA cycle) and its related proteins, suggesting increased energy generation. The metabolomics showed an up-regulation of metabolites involved in the urea cycle, with which the transcriptome data were highly consistent, indicating accelerated energy expenditure. The TCA cycle and the urea cycle are likely be accelerated in a concerted manner, since they are directly connected by mutually providing each other's intermediates. The up-regulation of these pathways might result in a metabolic shift causing increased ATP turnover, which is related to the alterations of lipid metabolism. This mechanism may play an important part in the suppressive effects of coffee consumption on obesity, inflammation, and hepatosteatosis. This study newly revealed global metabolic alterations induced by coffee intake, providing significant insights into the association between coffee intake and the prevention of type 2 diabetes, utilizing the benefits of multi-omics analyses.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24618914</pmid><doi>10.1371/journal.pone.0091134</doi><tpages>e91134</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Animals Biology Coffee Consumption Deoxyribonucleic acid Development and progression Diabetes mellitus DNA DNA microarrays Drinking Behavior Energy expenditure Epidemiology Gene expression Gene Expression Profiling Health risks High fat diet Intermediates Isocitrate dehydrogenase Lipid metabolism Liver - metabolism Male Medicine Metabolic Networks and Pathways Metabolism Metabolites Metabolome Metabolomics Metabolomics - methods Mice Models, Animal Obesity Proteins Proteome Proteomics Risk reduction Tricarboxylic acid cycle Type 2 diabetes Urea Urea - metabolism |
| title | An integrated multi-omics study revealed metabolic alterations underlying the effects of coffee consumption |
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