Epigenetic silencing of apoptosis-inducing gene expression can be efficiently overcome by combined SAHA and TRAIL treatment in uterine sarcoma cells

The lack of knowledge about molecular pathology of uterine sarcomas with a representation of 3-7% of all malignant uterine tumors prevents the establishment of effective therapy protocols. Here, we explored advanced therapeutic options to the previously discovered antitumorigenic effects of the hist...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e91558
Hauptverfasser:	Fröhlich, Leopold F, Mrakovcic, Maria, Smole, Claudia, Lahiri, Pooja, Zatloukal, Kurt
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2'-deoxycytidine Acetylation Apoptosis Apoptosis - genetics Biology Biotechnology Caspase Caspase 3 - metabolism Caspase 8 - genetics Caspase 8 - metabolism Caspase-3 Caspase-8 Cell death Cell Line, Tumor Combinatorial analysis Combined treatment Cytotoxicity Deoxyribonucleic acid Deregulation DNA DNA Methylation Drug Resistance, Neoplasm - genetics Drug Synergism Enzyme Activation - drug effects Epigenesis, Genetic Epigenetic inheritance Female Gene expression Gene Expression Regulation, Neoplastic Gene sequencing Gene transfer Gene Transfer Techniques Genes Genetic engineering Health aspects Histone deacetylase Histone Deacetylase Inhibitors Humans Hydroxamic acid Hydroxamic Acids - pharmacology Hydroxamic Acids - toxicity Medicine Membrane potential Membrane Potential, Mitochondrial Mitochondria Mitochondria - drug effects Mitochondria - metabolism Molecular modelling Nucleotide sequence Poly(ADP-ribose) polymerase Promoter Regions, Genetic Promoters (Genetics) Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Sarcoma Sarcoma - genetics TNF-Related Apoptosis-Inducing Ligand - pharmacology TNF-Related Apoptosis-Inducing Ligand - toxicity TRAIL protein Tumor cell lines Tumor necrosis factor Tumors Uterine cancer Uterine Neoplasms - genetics Uterus
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!