Physical, cognitive and emotional factors contributing to quality of life, functional health and participation in community dwelling in chronic kidney disease
Quality of life (QoL) impairment is a well-known consequence of chronic kidney disease (CKD). The factors influencing QoL and late life functional health are poorly examined. Using questionnaires combined with neuropsychological examinations, we prospectively evaluated physical, cognitive, and emoti...
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| Veröffentlicht in: | PloS one 2014-03, Vol.9 (3), p.e91176-e91176 |
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| description | Quality of life (QoL) impairment is a well-known consequence of chronic kidney disease (CKD). The factors influencing QoL and late life functional health are poorly examined.
Using questionnaires combined with neuropsychological examinations, we prospectively evaluated physical, cognitive, and emotional factors influencing QoL, functional health and participation in community dwelling in 119 patients with CKD stages 3-5 including hemodialysis (61.5±15.7years; 63% men) and 54 control patients of the same age without CKD but with similar cardiovascular risk profile.
Compared with control patients, CKD patients showed impairment of the physical component of QoL and overall function, assessed by the SF-36 and LLFDI, whereas disability, assessed by LLFDI, was selectively impaired in CKD patients on hemodialysis. Multivariable linear regressions (forced entry) confirmed earlier findings that CKD stage (β = -0.24; p = 0.012) and depression (β = -0.30; p = 0.009) predicted the QoL physical component. Hitherto unknown, CKD stage (β = -0.23; p = 0.007), cognition (β = 0.20; p = 0.018), and depression (β = -0.51; |
| doi_str_mv | 10.1371/journal.pone.0091176 |
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Using questionnaires combined with neuropsychological examinations, we prospectively evaluated physical, cognitive, and emotional factors influencing QoL, functional health and participation in community dwelling in 119 patients with CKD stages 3-5 including hemodialysis (61.5±15.7years; 63% men) and 54 control patients of the same age without CKD but with similar cardiovascular risk profile.
Compared with control patients, CKD patients showed impairment of the physical component of QoL and overall function, assessed by the SF-36 and LLFDI, whereas disability, assessed by LLFDI, was selectively impaired in CKD patients on hemodialysis. Multivariable linear regressions (forced entry) confirmed earlier findings that CKD stage (β = -0.24; p = 0.012) and depression (β = -0.30; p = 0.009) predicted the QoL physical component. Hitherto unknown, CKD stage (β = -0.23; p = 0.007), cognition (β = 0.20; p = 0.018), and depression (β = -0.51; <0.001) predicted disability assessed by the LLFDI, while age (β = -0.20; p = 0.023), male gender (B = 5.01; p = 0.004), CKD stage (β = -0.23; p = 0.005), stroke history (B = -9.00; p = 0.034), and depression (β = -0.41; p<0.001) predicted overall function. Interestingly, functional health deficits, cognitive disturbances, depression, and anxiety were evident almost only in CKD patients with coronary heart disease (found in 34.2% of CKD patients). The physical component of QoL and functional health decreased with age and depressive symptoms, and increased with cognitive abilities.
In CKD, QoL, functional health, and participation in community dwelling are influenced by physical, cognitive, and emotional factors, most prominently in coronary heart disease patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0091176</identifier><identifier>PMID: 24614180</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Affect ; Anxiety ; Cardiac patients ; Cardiovascular disease ; Case-Control Studies ; Chronic kidney failure ; Cognition ; Cognitive disorders ; Cohort Studies ; Community Participation ; Coronary heart disease ; Depression (Mood disorder) ; Depression - psychology ; Emotions ; Family medical history ; Female ; Health ; Hemodialysis ; Hospitals ; Humans ; Kidney diseases ; Laboratories ; Male ; Medical research ; Medicine ; Mental depression ; Middle Aged ; Mortality ; Myocardial Infarction - complications ; Myocardial Infarction - pathology ; Myocardial Infarction - physiopathology ; Nephrology ; Neurology ; Patients ; Quality of Life ; Questionnaires ; Renal Dialysis ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - physiopathology ; Residence Characteristics ; Social and Behavioral Sciences ; Stroke ; Studies ; Surveys</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e91176-e91176</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Seidel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Seidel et al 2014 Seidel et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-faaa37ad8efaefbbec57caa759eec5a8e7370cc56ddd5725b1b3c9a2c95e8f23</citedby><cites>FETCH-LOGICAL-c758t-faaa37ad8efaefbbec57caa759eec5a8e7370cc56ddd5725b1b3c9a2c95e8f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948783/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948783/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2930,23873,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24614180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kleinschnitz, Christoph</contributor><creatorcontrib>Seidel, Ulla K</creatorcontrib><creatorcontrib>Gronewold, Janine</creatorcontrib><creatorcontrib>Volsek, Michaela</creatorcontrib><creatorcontrib>Todica, Olga</creatorcontrib><creatorcontrib>Kribben, Andreas</creatorcontrib><creatorcontrib>Bruck, Heike</creatorcontrib><creatorcontrib>Hermann, Dirk M</creatorcontrib><title>Physical, cognitive and emotional factors contributing to quality of life, functional health and participation in community dwelling in chronic kidney disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Quality of life (QoL) impairment is a well-known consequence of chronic kidney disease (CKD). The factors influencing QoL and late life functional health are poorly examined.
Using questionnaires combined with neuropsychological examinations, we prospectively evaluated physical, cognitive, and emotional factors influencing QoL, functional health and participation in community dwelling in 119 patients with CKD stages 3-5 including hemodialysis (61.5±15.7years; 63% men) and 54 control patients of the same age without CKD but with similar cardiovascular risk profile.
Compared with control patients, CKD patients showed impairment of the physical component of QoL and overall function, assessed by the SF-36 and LLFDI, whereas disability, assessed by LLFDI, was selectively impaired in CKD patients on hemodialysis. Multivariable linear regressions (forced entry) confirmed earlier findings that CKD stage (β = -0.24; p = 0.012) and depression (β = -0.30; p = 0.009) predicted the QoL physical component. Hitherto unknown, CKD stage (β = -0.23; p = 0.007), cognition (β = 0.20; p = 0.018), and depression (β = -0.51; <0.001) predicted disability assessed by the LLFDI, while age (β = -0.20; p = 0.023), male gender (B = 5.01; p = 0.004), CKD stage (β = -0.23; p = 0.005), stroke history (B = -9.00; p = 0.034), and depression (β = -0.41; p<0.001) predicted overall function. Interestingly, functional health deficits, cognitive disturbances, depression, and anxiety were evident almost only in CKD patients with coronary heart disease (found in 34.2% of CKD patients). The physical component of QoL and functional health decreased with age and depressive symptoms, and increased with cognitive abilities.
In CKD, QoL, functional health, and participation in community dwelling are influenced by physical, cognitive, and emotional factors, most prominently in coronary heart disease patients.</description><subject>Affect</subject><subject>Anxiety</subject><subject>Cardiac patients</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Chronic kidney failure</subject><subject>Cognition</subject><subject>Cognitive disorders</subject><subject>Cohort Studies</subject><subject>Community Participation</subject><subject>Coronary heart disease</subject><subject>Depression (Mood disorder)</subject><subject>Depression - psychology</subject><subject>Emotions</subject><subject>Family medical history</subject><subject>Female</subject><subject>Health</subject><subject>Hemodialysis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Nephrology</subject><subject>Neurology</subject><subject>Patients</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Renal Dialysis</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Residence Characteristics</subject><subject>Social and Behavioral Sciences</subject><subject>Stroke</subject><subject>Studies</subject><subject>Surveys</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNU9tu1DAQjRCIlsIfIIhUCYHUXex4HdsvSFXFpVKlIqh4tSbOeNclsbdxUujP8K04u2nVRX1Afog1c86ZzPFMlr2kZE6ZoO8vw9B5aObr4HFOiKJUlI-yfapYMSsLwh7fu-9lz2K8JIQzWZZPs71iUdIFlWQ_-_N1dROdgeYoN2HpXe-uMQdf59iG3oVUILdg-tDFlPd956qhd36Z9yG_GqBx_U0ebN44i0e5HbyZOCuEpl9thNbQ9c64NYyp3Pmk07aDH5n1L2yaUW2Mrrrgncl_utpjSrmIEPF59sRCE_HF9D3ILj59vDj5Mjs7_3x6cnw2M4LLfmYBgAmoJVpAW1VouDAAgitMV5AomCDG8LKuay4KXtGKGQWFURylLdhB9noru25C1JOzUVNOSiJ4KUlCnG4RdYBLve5cC92NDuD0JhC6pd702aC2BTIlmVJK8gWRSlEplUFZ1ISXprJJ68NUbaharA0mX6HZEd3NeLfSy3CtmVpIIVkSeDsJdOFqwNjr1kWTvASPYdj-t1CUC5Ggh_9AH-5uQi0hNeC8DamuGUX18UJIIYqSjy7NH0ClU2Pr0nSgdSm-Q3i3QxgnCH_3Sxhi1Kffv_0_9vzHLvbNPex21mJohnHC4i5wsQWaLsTYob0zmRI9btGtG3rcIj1tUaK9uv9Ad6TbtWF_AaCKHIs</recordid><startdate>20140310</startdate><enddate>20140310</enddate><creator>Seidel, Ulla K</creator><creator>Gronewold, Janine</creator><creator>Volsek, Michaela</creator><creator>Todica, Olga</creator><creator>Kribben, Andreas</creator><creator>Bruck, Heike</creator><creator>Hermann, Dirk M</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140310</creationdate><title>Physical, cognitive and emotional factors contributing to quality of life, functional health and participation in community dwelling in chronic kidney disease</title><author>Seidel, Ulla K ; Gronewold, Janine ; Volsek, Michaela ; Todica, Olga ; Kribben, Andreas ; Bruck, Heike ; Hermann, Dirk M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-faaa37ad8efaefbbec57caa759eec5a8e7370cc56ddd5725b1b3c9a2c95e8f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Affect</topic><topic>Anxiety</topic><topic>Cardiac patients</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Chronic kidney failure</topic><topic>Cognition</topic><topic>Cognitive disorders</topic><topic>Cohort Studies</topic><topic>Community Participation</topic><topic>Coronary heart disease</topic><topic>Depression (Mood disorder)</topic><topic>Depression - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seidel, Ulla K</au><au>Gronewold, Janine</au><au>Volsek, Michaela</au><au>Todica, Olga</au><au>Kribben, Andreas</au><au>Bruck, Heike</au><au>Hermann, Dirk M</au><au>Kleinschnitz, Christoph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical, cognitive and emotional factors contributing to quality of life, functional health and participation in community dwelling in chronic kidney disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-03-10</date><risdate>2014</risdate><volume>9</volume><issue>3</issue><spage>e91176</spage><epage>e91176</epage><pages>e91176-e91176</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Quality of life (QoL) impairment is a well-known consequence of chronic kidney disease (CKD). The factors influencing QoL and late life functional health are poorly examined.
Using questionnaires combined with neuropsychological examinations, we prospectively evaluated physical, cognitive, and emotional factors influencing QoL, functional health and participation in community dwelling in 119 patients with CKD stages 3-5 including hemodialysis (61.5±15.7years; 63% men) and 54 control patients of the same age without CKD but with similar cardiovascular risk profile.
Compared with control patients, CKD patients showed impairment of the physical component of QoL and overall function, assessed by the SF-36 and LLFDI, whereas disability, assessed by LLFDI, was selectively impaired in CKD patients on hemodialysis. Multivariable linear regressions (forced entry) confirmed earlier findings that CKD stage (β = -0.24; p = 0.012) and depression (β = -0.30; p = 0.009) predicted the QoL physical component. Hitherto unknown, CKD stage (β = -0.23; p = 0.007), cognition (β = 0.20; p = 0.018), and depression (β = -0.51; <0.001) predicted disability assessed by the LLFDI, while age (β = -0.20; p = 0.023), male gender (B = 5.01; p = 0.004), CKD stage (β = -0.23; p = 0.005), stroke history (B = -9.00; p = 0.034), and depression (β = -0.41; p<0.001) predicted overall function. Interestingly, functional health deficits, cognitive disturbances, depression, and anxiety were evident almost only in CKD patients with coronary heart disease (found in 34.2% of CKD patients). The physical component of QoL and functional health decreased with age and depressive symptoms, and increased with cognitive abilities.
In CKD, QoL, functional health, and participation in community dwelling are influenced by physical, cognitive, and emotional factors, most prominently in coronary heart disease patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24614180</pmid><doi>10.1371/journal.pone.0091176</doi><tpages>e91176</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-03, Vol.9 (3), p.e91176-e91176 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Affect Anxiety Cardiac patients Cardiovascular disease Case-Control Studies Chronic kidney failure Cognition Cognitive disorders Cohort Studies Community Participation Coronary heart disease Depression (Mood disorder) Depression - psychology Emotions Family medical history Female Health Hemodialysis Hospitals Humans Kidney diseases Laboratories Male Medical research Medicine Mental depression Middle Aged Mortality Myocardial Infarction - complications Myocardial Infarction - pathology Myocardial Infarction - physiopathology Nephrology Neurology Patients Quality of Life Questionnaires Renal Dialysis Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - physiopathology Residence Characteristics Social and Behavioral Sciences Stroke Studies Surveys |
| title | Physical, cognitive and emotional factors contributing to quality of life, functional health and participation in community dwelling in chronic kidney disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T11%3A32%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Physical,%20cognitive%20and%20emotional%20factors%20contributing%20to%20quality%20of%20life,%20functional%20health%20and%20participation%20in%20community%20dwelling%20in%20chronic%20kidney%20disease&rft.jtitle=PloS%20one&rft.au=Seidel,%20Ulla%20K&rft.date=2014-03-10&rft.volume=9&rft.issue=3&rft.spage=e91176&rft.epage=e91176&rft.pages=e91176-e91176&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0091176&rft_dat=%3Cgale_plos_%3EA478772652%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1506075680&rft_id=info:pmid/24614180&rft_galeid=A478772652&rft_doaj_id=oai_doaj_org_article_f2e398399985408991889ce82d056cbf&rfr_iscdi=true |