Effects of green tea extract on insulin resistance and glucagon-like peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial
The aim of this study is to investigate the effect of green tea extract on patients with type 2 diabetes mellitus and lipid abnormalities on glycemic and lipid profiles, and hormone peptides by a double-blinded, randomized and placebo-controlled clinical trial. This trial enrolled 92 subjects with t...
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| Veröffentlicht in: | PloS one 2014-03, Vol.9 (3), p.e91163 |
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| creator | Liu, Chia-Yu Huang, Chien-Jung Huang, Lin-Huang Chen, I-Ju Chiu, Jung-Peng Hsu, Chung-Hua |
| description | The aim of this study is to investigate the effect of green tea extract on patients with type 2 diabetes mellitus and lipid abnormalities on glycemic and lipid profiles, and hormone peptides by a double-blinded, randomized and placebo-controlled clinical trial. This trial enrolled 92 subjects with type 2 diabetes mellitus and lipid abnormalities randomized into 2 arms, each arm comprising 46 participants. Of the participants, 39 in therapeutic arm took 500 mg green tea extract, three times a day, while 38 in control arm took cellulose with the same dose and frequency to complete the 16-week study. Anthropometrics measurements, glycemic and lipid profiles, safety parameters, and obesity-related hormone peptides were analyzed at screening and after 16-week course. Within-group comparisons showed that green tea extract caused a significant decrease in triglyceride and homeostasis model assessment of insulin resistance index after 16 weeks. Green tea extract also increased significantly high density lipoprotein cholesterol. The HOMA-IR index decreased from 5.4±3.9 to 3.5±2.0 in therapeutic arm only. Adiponectin, apolipoprotein A1, and apolipoprotein B100 increased significantly in both arms, but only glucagon-like peptide 1 increased in the therapeutic arm. However, only decreasing trend in triglyceride was found in between-group comparison. Our study suggested that green tea extract significantly improved insulin resistance and increased glucagon-like peptide 1 only in within-group comparison. The potential effects of green tea extract on insulin resistance and glucagon-like peptide 1 warrant further investigation.
ClinicalTrials.gov NCT01360567. |
| doi_str_mv | 10.1371/journal.pone.0091163 |
| format | Article |
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ClinicalTrials.gov NCT01360567.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0091163</identifier><identifier>PMID: 24614112</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Adiponectin ; Apolipoproteins ; Biology ; Body measurements ; Care and treatment ; Cellulose ; Cholesterol ; Clinical trials ; Demography ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes therapy ; Double-Blind Method ; Female ; Glucagon ; Glucagon-like peptide 1 ; Glucagon-Like Peptide 1 - metabolism ; Green tea ; Health aspects ; Homeostasis ; Humans ; Insulin ; Insulin Resistance ; Lipids - blood ; Male ; Medical research ; Medicine ; Middle Aged ; Patients ; Peptides ; Placebos ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Product development ; Randomization ; Tea ; Triglycerides ; Type 2 diabetes</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e91163</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Liu et al 2014 Liu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c743t-4094293d492968562c518bd7683a2a1796b966aa86be9520ce3880bbcec4a1e93</citedby><cites>FETCH-LOGICAL-c743t-4094293d492968562c518bd7683a2a1796b966aa86be9520ce3880bbcec4a1e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948786/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948786/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24614112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Chia-Yu</creatorcontrib><creatorcontrib>Huang, Chien-Jung</creatorcontrib><creatorcontrib>Huang, Lin-Huang</creatorcontrib><creatorcontrib>Chen, I-Ju</creatorcontrib><creatorcontrib>Chiu, Jung-Peng</creatorcontrib><creatorcontrib>Hsu, Chung-Hua</creatorcontrib><title>Effects of green tea extract on insulin resistance and glucagon-like peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The aim of this study is to investigate the effect of green tea extract on patients with type 2 diabetes mellitus and lipid abnormalities on glycemic and lipid profiles, and hormone peptides by a double-blinded, randomized and placebo-controlled clinical trial. This trial enrolled 92 subjects with type 2 diabetes mellitus and lipid abnormalities randomized into 2 arms, each arm comprising 46 participants. Of the participants, 39 in therapeutic arm took 500 mg green tea extract, three times a day, while 38 in control arm took cellulose with the same dose and frequency to complete the 16-week study. Anthropometrics measurements, glycemic and lipid profiles, safety parameters, and obesity-related hormone peptides were analyzed at screening and after 16-week course. Within-group comparisons showed that green tea extract caused a significant decrease in triglyceride and homeostasis model assessment of insulin resistance index after 16 weeks. Green tea extract also increased significantly high density lipoprotein cholesterol. The HOMA-IR index decreased from 5.4±3.9 to 3.5±2.0 in therapeutic arm only. Adiponectin, apolipoprotein A1, and apolipoprotein B100 increased significantly in both arms, but only glucagon-like peptide 1 increased in the therapeutic arm. However, only decreasing trend in triglyceride was found in between-group comparison. Our study suggested that green tea extract significantly improved insulin resistance and increased glucagon-like peptide 1 only in within-group comparison. The potential effects of green tea extract on insulin resistance and glucagon-like peptide 1 warrant further investigation.
ClinicalTrials.gov NCT01360567.</description><subject>Abnormalities</subject><subject>Adiponectin</subject><subject>Apolipoproteins</subject><subject>Biology</subject><subject>Body measurements</subject><subject>Care and treatment</subject><subject>Cellulose</subject><subject>Cholesterol</subject><subject>Clinical trials</subject><subject>Demography</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes therapy</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Glucagon</subject><subject>Glucagon-like peptide 1</subject><subject>Glucagon-Like Peptide 1 - metabolism</subject><subject>Green tea</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Peptides</subject><subject>Placebos</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Product development</subject><subject>Randomization</subject><subject>Tea</subject><subject>Triglycerides</subject><subject>Type 2 diabetes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9-K1DAUxoso7jr6BqIBQRDsmDRt2nghLMuqAwsL_rsNaXLayZpJapKq6-v5YmZ2Z5cdUJBetEl-35fDd3qK4jHBS0Jb8urcz8FJu5y8gyXGnBBG7xSHhNOqZBWmd299HxQPYjzHuKEdY_eLg6pmpCakOix-nwwDqBSRH9AYABxKIBH8TEGqhLxDxsXZGocCRBOTdAqQdBqNdlZy9K605iugCaZkNCCScTTJZMBlyx8mrVG6mABVSBvZQ4J4KbZmMhrJ3vmwkdZkPL5GEoV85jfmF-iXSPu5t1D2-Wq9XW9lk5UKel8q71Lw1oJGKRhpHxb3BmkjPNq9F8Xntyefjt-Xp2fvVsdHp6Vqa5rKGvO64lTXvOKsa1ilGtL1umUdlZUkLWc9Z0zKjvXAmworoF2H-16BqiUBThfF0yvfyfoodvlHQRrMcNs0VZOJ1RWhvTwXUzAbGS6El0ZcbvgwChmSURZEz2sMbOA1xbpWXSNB6443dUs5Hppc8KJ4s7tt7jegVY40SLtnun_izFqM_rugvO7ajmWDZzuD4L_NENM_St5Ro8xVGTf4bes3JipxVLdd21YsB7Qoln-h8qNhY3I_YDB5f0_wYk-w7Vn-q0Y5xyhWHz_8P3v2ZZ99fotdg7RpHb2dk_Eu7oP1FaiCjzHAcJMcwWI7QNdpiO0Aid0AZdmT26nfiK4nhv4BE1MYjQ</recordid><startdate>20140310</startdate><enddate>20140310</enddate><creator>Liu, Chia-Yu</creator><creator>Huang, Chien-Jung</creator><creator>Huang, Lin-Huang</creator><creator>Chen, I-Ju</creator><creator>Chiu, Jung-Peng</creator><creator>Hsu, Chung-Hua</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140310</creationdate><title>Effects of green tea extract on insulin resistance and glucagon-like peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial</title><author>Liu, Chia-Yu ; Huang, Chien-Jung ; Huang, Lin-Huang ; Chen, I-Ju ; Chiu, Jung-Peng ; Hsu, Chung-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c743t-4094293d492968562c518bd7683a2a1796b966aa86be9520ce3880bbcec4a1e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abnormalities</topic><topic>Adiponectin</topic><topic>Apolipoproteins</topic><topic>Biology</topic><topic>Body measurements</topic><topic>Care and treatment</topic><topic>Cellulose</topic><topic>Cholesterol</topic><topic>Clinical trials</topic><topic>Demography</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes therapy</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Glucagon</topic><topic>Glucagon-like peptide 1</topic><topic>Glucagon-Like Peptide 1 - metabolism</topic><topic>Green tea</topic><topic>Health aspects</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Peptides</topic><topic>Placebos</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Product development</topic><topic>Randomization</topic><topic>Tea</topic><topic>Triglycerides</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Chia-Yu</creatorcontrib><creatorcontrib>Huang, Chien-Jung</creatorcontrib><creatorcontrib>Huang, Lin-Huang</creatorcontrib><creatorcontrib>Chen, I-Ju</creatorcontrib><creatorcontrib>Chiu, Jung-Peng</creatorcontrib><creatorcontrib>Hsu, Chung-Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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This trial enrolled 92 subjects with type 2 diabetes mellitus and lipid abnormalities randomized into 2 arms, each arm comprising 46 participants. Of the participants, 39 in therapeutic arm took 500 mg green tea extract, three times a day, while 38 in control arm took cellulose with the same dose and frequency to complete the 16-week study. Anthropometrics measurements, glycemic and lipid profiles, safety parameters, and obesity-related hormone peptides were analyzed at screening and after 16-week course. Within-group comparisons showed that green tea extract caused a significant decrease in triglyceride and homeostasis model assessment of insulin resistance index after 16 weeks. Green tea extract also increased significantly high density lipoprotein cholesterol. The HOMA-IR index decreased from 5.4±3.9 to 3.5±2.0 in therapeutic arm only. Adiponectin, apolipoprotein A1, and apolipoprotein B100 increased significantly in both arms, but only glucagon-like peptide 1 increased in the therapeutic arm. However, only decreasing trend in triglyceride was found in between-group comparison. Our study suggested that green tea extract significantly improved insulin resistance and increased glucagon-like peptide 1 only in within-group comparison. The potential effects of green tea extract on insulin resistance and glucagon-like peptide 1 warrant further investigation.
ClinicalTrials.gov NCT01360567.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24614112</pmid><doi>10.1371/journal.pone.0091163</doi><tpages>e91163</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Adiponectin Apolipoproteins Biology Body measurements Care and treatment Cellulose Cholesterol Clinical trials Demography Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes therapy Double-Blind Method Female Glucagon Glucagon-like peptide 1 Glucagon-Like Peptide 1 - metabolism Green tea Health aspects Homeostasis Humans Insulin Insulin Resistance Lipids - blood Male Medical research Medicine Middle Aged Patients Peptides Placebos Plant Extracts - pharmacology Plant Extracts - therapeutic use Product development Randomization Tea Triglycerides Type 2 diabetes |
| title | Effects of green tea extract on insulin resistance and glucagon-like peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial |
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