High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma
Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 w...
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| Veröffentlicht in: | PloS one 2014-03, Vol.9 (3), p.e90955-e90955 |
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| creator | Zhang, Yi-An Zhu, Ji-Min Yin, Jie Tang, Wen-Qing Guo, Yan-Mei Shen, Xi-Zhong Liu, Tao-Tao |
| description | Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC. |
| doi_str_mv | 10.1371/journal.pone.0090955 |
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In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0090955</identifier><identifier>PMID: 24608171</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antigens ; Ataxia ; Biology ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Breast cancer ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Cell growth ; Cell Line, Tumor ; Cell migration ; Cell Movement ; Cell Proliferation ; Cell survival ; Female ; Follow-Up Studies ; Gene Expression ; Hepatocellular carcinoma ; Humans ; Liver cancer ; Liver Neoplasms - genetics ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Medical prognosis ; Medicine ; Middle Aged ; Myoclonus ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Prognosis ; Protein binding ; Ribonucleic acid ; RNA ; RNA, Small Interfering - genetics ; RNA, Small Interfering - metabolism ; RNA-binding protein ; RNA-Binding Proteins - antagonists & inhibitors ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; Rodents ; Survival ; Survival Analysis ; Tumor cell lines ; Tumors</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e90955-e90955</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Zhang et al 2014 Zhang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8e536010e1a3c5f76e33bd638e37a651a919ed8094174ddc5eb244642d668ee53</citedby><cites>FETCH-LOGICAL-c692t-8e536010e1a3c5f76e33bd638e37a651a919ed8094174ddc5eb244642d668ee53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946567/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946567/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24608171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yi-An</creatorcontrib><creatorcontrib>Zhu, Ji-Min</creatorcontrib><creatorcontrib>Yin, Jie</creatorcontrib><creatorcontrib>Tang, Wen-Qing</creatorcontrib><creatorcontrib>Guo, Yan-Mei</creatorcontrib><creatorcontrib>Shen, Xi-Zhong</creatorcontrib><creatorcontrib>Liu, Tao-Tao</creatorcontrib><title>High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC.</description><subject>Antigens</subject><subject>Ataxia</subject><subject>Biology</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast cancer</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement</subject><subject>Cell Proliferation</subject><subject>Cell survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene Expression</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Myoclonus</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Prognosis</subject><subject>Protein binding</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Small Interfering - genetics</subject><subject>RNA, Small Interfering - metabolism</subject><subject>RNA-binding protein</subject><subject>RNA-Binding Proteins - antagonists & inhibitors</subject><subject>RNA-Binding Proteins - genetics</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>Rodents</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk81q3DAUhU1padK0b1BaQ6G0i5lKlizbm0AIbTMQCPRvK2T52qNBo-tIdpq-fTUZJ4xLFkULCfk7R7rHuknympIlZQX9tMHRO2WXPTpYElKRKs-fJMe0YtlCZIQ9PVgfJS9C2BCSs1KI58lRxgUpaUGPk-sL061TuO09hGDQpdimDkaPC3QaLXZGK5vegBt8nJUbTAcupalG78GqAUL62wzrtEf0ae-xcxhMSI1L19CrATVYO1rlU628Ng636mXyrFU2wKtpPkl-fvn84_xicXn1dXV-drnQosqGRQk5E4QSoIrpvC0EMFY3gpXACiVyqipaQVOSitOCN43Ooc44FzxrhCghik-St3vf3mKQU1pB0pzwqigKWkRitScaVBvZe7NV_o9EZeTdBvpOKj8YbUE2mciA5zVvhOZZnamG0VY3dQ7A66rS0et0Om2st9DofWAz0_kXZ9aywxvJKi5ysbvMh8nA4_UIYZBbE3bpKQc43t1bcMJYJSL67h_08eomqlOxAONajOfqnak840VZFCzWFKnlI1QcDWyNjk-rNXF_Jvg4E0RmgNuhU2MIcvX92_-zV7_m7PsDdg3KDuuAdhziowxzkO9B7TEED-1DyJTIXWfcpyF3nSGnzoiyN4c_6EF03wrsLyD-Cqo</recordid><startdate>20140307</startdate><enddate>20140307</enddate><creator>Zhang, Yi-An</creator><creator>Zhu, Ji-Min</creator><creator>Yin, Jie</creator><creator>Tang, Wen-Qing</creator><creator>Guo, Yan-Mei</creator><creator>Shen, Xi-Zhong</creator><creator>Liu, Tao-Tao</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140307</creationdate><title>High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma</title><author>Zhang, Yi-An ; Zhu, Ji-Min ; Yin, Jie ; Tang, Wen-Qing ; Guo, Yan-Mei ; Shen, Xi-Zhong ; Liu, Tao-Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-8e536010e1a3c5f76e33bd638e37a651a919ed8094174ddc5eb244642d668ee53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antigens</topic><topic>Ataxia</topic><topic>Biology</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast cancer</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement</topic><topic>Cell Proliferation</topic><topic>Cell survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene Expression</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Myoclonus</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - 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In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24608171</pmid><doi>10.1371/journal.pone.0090955</doi><tpages>e90955</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens Ataxia Biology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Cell growth Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Cell survival Female Follow-Up Studies Gene Expression Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical prognosis Medicine Middle Aged Myoclonus Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Prognosis Protein binding Ribonucleic acid RNA RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-binding protein RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Rodents Survival Survival Analysis Tumor cell lines Tumors |
| title | High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma |
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