Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex

The expression of the wild-type tumor-suppressor gene DBC2 (Deleted-in-Breast Cancer 2, a.k.a RhoBTB2) is suppressed in many cancers, in addition to breast cancer. In a screen for Cdc37-associated proteins, DBC2 was identified to be a potential client protein of the 90 kDa heat shock protein (Hsp90)...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e90054-e90054
Hauptverfasser:	Manjarrez, Jacob R, Sun, Liang, Prince, Thomas, Matts, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Apoptosis Assembly Biochemistry Biology Bladder Breast cancer Cancer Cell cycle Cell growth Cell Line Chemical inhibitors Cullin Proteins - genetics Cullin Proteins - metabolism G proteins Geldanamycin Gene expression Genes GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Guanosine triphosphate Heat shock proteins HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Hsp90 protein Humans Immunoprecipitation Kinases Ligases Mass Spectrometry Medical research Medicine Molecular biology Molybdate Mutation Protein Binding Proteins Proteomics Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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