Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats

Animal models for cystic fibrosis (CF) have contributed significantly to our understanding of disease pathogenesis. Here we describe development and characterization of the first cystic fibrosis rat, in which the cystic fibrosis transmembrane conductance regulator gene (CFTR) was knocked out using a...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e91253
Hauptverfasser:	Tuggle, Katherine L, Birket, Susan E, Cui, Xiaoxia, Hong, Jeong, Warren, Joe, Reid, Lara, Chambers, Andre, Ji, Diana, Gamber, Kevin, Chu, Kengyeh K, Tearney, Guillermo, Tang, Li Ping, Fortenberry, James A, Du, Ming, Cadillac, Joan M, Bedwell, David M, Rowe, Steven M, Sorscher, Eric J, Fanucchi, Michelle V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biology Constipation Cystic fibrosis Cystic Fibrosis Transmembrane Conductance Regulator - deficiency Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Dentition Environmental health Epithelium - metabolism Female Gene Knockout Techniques Genetic aspects Genetic engineering Health sciences Hospitals Humans Ileum - growth & development Ileum - physiology Ion Channel Gating Ion Transport Laboratories Male Medicine Membrane Potentials Microinjections Molecular Sequence Data Mucus - metabolism Nose - physiology Organogenesis Pathogenesis Pathology Public health Rats, Sprague-Dawley Rodents Studies Trachea - anatomy & histology Trachea - physiology Vas Deferens - abnormalities Zinc finger proteins
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