Polycomb binding precedes early-life stress responsive DNA methylation at the Avp enhancer

Early-life stress (ELS) in mice causes sustained hypomethylation at the downstream Avp enhancer, subsequent overexpression of hypothalamic Avp and increased stress responsivity. The sequence of events leading to Avp enhancer methylation is presently unknown. Here, we used an embryonic stem cell-deri...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e90277-e90277
Hauptverfasser:	Murgatroyd, Chris, Spengler, Dietmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Arginine Vasopressin - genetics Biology Brain Cell culture Cell Differentiation Cell Line Chromatin Chromatin - genetics Chromatin - metabolism Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation Embryonic stem cells Enhancer Elements, Genetic Epigenesis, Genetic Epigenetic inheritance Epigenetics Gene Expression Genes Genetic engineering Genomes Genomics Histones - metabolism Hypothalamus - cytology Male Medicine Methyl-CpG-Binding Protein 2 - metabolism Methylation Mice, Inbred C57BL Mice, Transgenic Neurons Polycomb Repressive Complex 2 - metabolism Polycomb-Group Proteins - metabolism Protein Binding Proteins Stem cells Stress (Psychology) Stress, Physiological
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