p-Hydroxyphenylpyruvate, an intermediate of the Phe/Tyr catabolism, improves mitochondrial oxidative metabolism under stressing conditions and prolongs survival in rats subjected to profound hemorrhagic shock

The aim of this study was to test the effect of a small volume administration of p-hydroxyphenylpyruvate (pHPP) in a rat model of profound hemorrhagic shock and to assess a possible metabolic mechanism of action of the compound. The results obtained show that hemorrhaged rats treated with 2-4% of th...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e90917
Hauptverfasser:	Cotoia, Antonella, Scrima, Rosella, Gefter, Julia V, Piccoli, Claudia, Cinnella, Gilda, Dambrosio, Michele, Fink, Mitchell P, Capitanio, Nazzareno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Biology Blood volume Catabolism Cell Line Cell Proliferation - drug effects Cell Respiration - drug effects Cell survival Cell Survival - drug effects Chemical compounds Electron transport Growth rate Hemodynamics - drug effects Hemorrhage Hemorrhagic shock Humans In vivo methods and tests Medicine Metabolic Networks and Pathways - drug effects Metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Oxidation-Reduction Oxidative metabolism Oxygen Pharmacology Phenylalanine - metabolism Phenylpyruvic Acids - pharmacology Phenylpyruvic Acids - therapeutic use Physiological aspects Rats Reactive oxygen species Reactive Oxygen Species - metabolism Shock, Hemorrhagic - chemically induced Shock, Hemorrhagic - drug therapy Shock, Hemorrhagic - metabolism Shock, Hemorrhagic - physiopathology Stress, Physiological - drug effects Subcellular Fractions - drug effects Subcellular Fractions - metabolism Substrates Superoxides - metabolism Survival Survival Analysis Tyrosine - metabolism
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Zusammenfassung:	The aim of this study was to test the effect of a small volume administration of p-hydroxyphenylpyruvate (pHPP) in a rat model of profound hemorrhagic shock and to assess a possible metabolic mechanism of action of the compound. The results obtained show that hemorrhaged rats treated with 2-4% of the estimated blood volume of pHPP survived significantly longer (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0090917