Antibodies with higher bactericidal activity induced by a Neisseria gonorrhoeae Rmp deletion mutant strain

Neisseria gonorrhoeae (N. gonorrhoeae) outer membrane protein reduction modifiable protein (Rmp) has strong immunogenicity. However, anti-Rmp antibodies block rather than preserve the antibacterial effects of protective antibodies, which hampers the development of vaccines for gonococcal infections....

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e90525
Hauptverfasser:	Li, Guocai, Xie, Rushan, Zhu, Xiaoping, Mao, Yanli, Liu, Shuangxi, Jiao, Hongmei, Yan, Hua, Xiong, Kun, Ji, Mingchun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibodies Antibodies, Bacterial - immunology Antigens Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bactericidal activity Biology Colonies Condoms Cytotoxicity Deletion mutant Deoxyribonucleic acid DNA Females Gene Deletion Gene mutation Genomes Gonorrhea Gonorrhea - genetics Gonorrhea - immunology Health aspects Homologous recombination Homology Humans Hybridization Immunogenicity Immunoglobulins Immunology Infection Infections Kanamycin Laboratory animals Medicine Membrane proteins Neisseria gonorrhoeae Neisseria gonorrhoeae - genetics Neisseria gonorrhoeae - growth & development Neisseria gonorrhoeae - immunology Neurosciences Peptides Proteins Sexually transmitted diseases STD Toxicity Vaccines Western blotting Zoonoses
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