Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity

Cationic, amphipathic host defense peptides represent a promising group of agents to be developed for anticancer applications. Poly-N-substituted glycines, or peptoids, are a class of biostable, peptidomimetic scaffold that can display a great diversity of side chains in highly tunable sequences via...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e90397-e90397
Hauptverfasser:	Huang, Wei, Seo, Jiwon, Willingham, Stephen B, Czyzewski, Ann M, Gonzalgo, Mark L, Weissman, Irving L, Barron, Annelise E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anticancer properties Antigens Antimicrobial agents Antimicrobial Cationic Peptides - chemical synthesis Antimicrobial Cationic Peptides - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antitumor activity Bioengineering Biology Biopolymers Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Cancer therapies Cancer treatment Cations Cell Line, Tumor Cell Survival - drug effects Chemistry Cytotoxicity Engineering Female Humans Mice Mice, Inbred NOD Microbial drug resistance Molecular Sequence Data Multidrug resistance Natural products Neoplasm Transplantation Penetration resistance Peptides Peptides - chemical synthesis Peptides - pharmacology Peptoids - chemical synthesis Peptoids - pharmacology Prostate Proteases Protein Stability Selectivity Solid phase methods Solid phase synthesis Solid-Phase Synthesis Techniques Solubility Stem cells Structure-Activity Relationship Toxicity Transplantation, Heterologous Tumor cell lines Xenografts Xenotransplantation
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