Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria

The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. We undertook testing Tempol--a superoxide dismutase (SOD) mimetic and pleiotropic intracellular antioxidant--in cells relevant to malaria pathogenesis in the context of co...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e87140-e87140
Hauptverfasser:	Francischetti, Ivo M B, Gordon, Emile, Bizzarro, Bruna, Gera, Nidhi, Andrade, Bruno B, Oliveira, Fabiano, Ma, Dongying, Assumpção, Teresa C F, Ribeiro, José M C, Pena, Mirna, Qi, Chen-Feng, Diouf, Ababacar, Moretz, Samuel E, Long, Carole A, Ackerman, Hans C, Pierce, Susan K, Sá-Nunes, Anderson, Waisberg, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Antioxidants Antioxidants (Nutrients) Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis Bioavailability Biology Blood-brain barrier Brain Brain research Catechin Cell culture Cell survival Cells, Cultured Chemokine CCL2 - metabolism Coagulation Cyclic N-Oxides - pharmacology Cyclic N-Oxides - therapeutic use Dendritic cells Dendritic Cells - drug effects Dendritic Cells - metabolism Diet therapy Endothelial cells Enzyme-Linked Immunosorbent Assay Epigallocatechin gallate Epigallocatechin-3-gallate Green tea Humans Immunology Infections Infectious diseases Inflammation Inhibition Interleukin 12 Interleukin 6 Interleukin 8 Interleukin-6 - metabolism Interleukin-8 - metabolism Intracellular Iron Laboratories Leukemia Lipopolysaccharides Lymphocytes Malaria Malaria, Cerebral - drug therapy Malaria, Cerebral - metabolism Medicine Metabolism Mice Mitochondria Mitogens Monocyte chemoattractant protein Monocyte chemoattractant protein 1 NAD(P)H oxidase Niacinamide Nicotinamide Nicotinamide adenine dinucleotide Oxidase Oxidases Oxidative stress Oxygen Parasitic diseases Pathogenesis Permeability Phosphates Plasmodium Plasmodium falciparum Promyeloid leukemia Reactive oxygen species Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Rodents Spin Labels Superoxide dismutase Superoxides Survival Tea Therapeutic targets Thromboplastin - metabolism Transcription Vector-borne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!