Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice

Respiratory syncytial viral (RSV) infections are a frequent cause of chronic obstructive pulmonary disease (COPD) exacerbations, which are a major factor in disease progression and mortality. RSV is able to evade antiviral defenses to persist in the lungs of COPD patients. Though RSV infection has b...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e90567
Hauptverfasser:	Foronjy, Robert F, Dabo, Abdoulaye J, Taggart, Clifford C, Weldon, Sinead, Geraghty, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Airspace Animals Antiviral agents Apoptosis Biology Cathepsins Cathepsins - metabolism Cell Line, Tumor Chronic obstructive lung disease Chronic obstructive pulmonary disease Cigarette smoke Cytokines - metabolism Destruction Diseases Enlargement Exposure Fibrosis Gelatinase A Gene Expression Regulation, Enzymologic Granulocyte-macrophage colony-stimulating factor Host-Pathogen Interactions Humans Immunoblotting Infections Infiltration Interferon Interleukin 13 Interleukin 17 Kinases Leukocytes (neutrophilic) Long-term effects Lung - metabolism Lung - physiopathology Lung - virology Lung diseases Lungs Lymphocytes Macrophages Matrix metalloproteinases Medicine Mice Mice, Inbred C57BL Nicotiana - chemistry Obstructive lung disease Peptide Hydrolases - metabolism Phosphatases Phosphates Phosphoprotein phosphatase Pneumonia - metabolism Pneumonia - physiopathology Pneumonia - virology Protease Protein phosphatase Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism Protein-tyrosine-phosphatase Proteinase Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Disease, Chronic Obstructive - virology RANTES Recurrent infection Respiratory syncytial virus Respiratory Syncytial Virus Infections - etiology Respiratory Syncytial Virus Infections - physiopathology Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Viruses - physiology Respiratory tract Respiratory tract diseases Reverse Transcriptase Polymerase Chain Reaction Rodents Smoke Smoke - adverse effects Smoking Tyrosine Viral infections Viruses γ-Interferon
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