Neutrophil gelatinase-associated lipocalin increases HLA-G(+)/FoxP3(+) T-regulatory cell population in an in vitro model of PBMC

Neutrophil gelatinase-associated lipocalin (NGAL) is emerging as a mediator of various biological and pathological states. However, the specific biological role of this molecule remains unclear, as it serves as a biomarker for many conditions. The high sensitivity of NGAL as a biomarker coupled with...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e89497-e89497
Hauptverfasser:	La Manna, Gaetano, Ghinatti, Giulia, Tazzari, Pier Luigi, Alviano, Francesco, Ricci, Francesca, Capelli, Irene, Cuna, Vania, Todeschini, Paola, Brunocilla, Eugenio, Pagliaro, Pasqualepaolo, Bonsi, Laura, Stefoni, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - metabolism Acute-Phase Proteins - pharmacology Adenosine Antigens Autoimmune diseases Biology Biomarkers CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell-mediated immunity Cellular stress response Centrifugation Cytometry Disease Embryology Enterobactin - pharmacology Flow cytometry Forkhead Transcription Factors - metabolism Foxp3 protein Free form Gelatinase Hematology Hemodialysis Histocompatibility antigen HLA Histology HLA-G Antigens - metabolism Hospitals Humans Immunity Immunological tolerance Immunology Immunomodulation Immunophenotyping Immunoregulation Immunosuppressive agents Inflammation Informed consent Iron Iron deficiency Kidneys Laboratories Leukocytes Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lipocalin Lipocalin-2 Lipocalins - metabolism Lipocalins - pharmacology Lymphocyte Activation - drug effects Lymphocytes Lymphocytes T Medicine Nephrology Neutrophils Nutrient deficiency Oncology Oxidative stress Peripheral blood mononuclear cells Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - pharmacology Rodents T-Lymphocyte Subsets T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transplants & implants
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