Syncytiotrophoblast vesicles show altered micro-RNA and haemoglobin content after ex-vivo perfusion of placentas with haemoglobin to mimic preeclampsia

Cell-free foetal haemoglobin (HbF) has been shown to play a role in the pathology of preeclampsia (PE). In the present study, we aimed to further characterize the harmful effects of extracellular free haemoglobin (Hb) on the placenta. In particular, we investigated whether cell-free Hb affects the r...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e90020-e90020
Hauptverfasser:	Cronqvist, Tina, Saljé, Karen, Familari, Mary, Guller, Seth, Schneider, Henning, Gardiner, Chris, Sargent, Ian L, Redman, Christopher W, Mörgelin, Matthias, Åkerström, Bo, Gram, Magnus, Hansson, Stefan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological Transport Biology Centrifugation Clinical Medicine Cotyledons Electron microscopy Extracellular Space - metabolism Female Gene expression Gynecology Hemoglobin Hemoglobins Hemoglobins - metabolism Humans Hypertension Hypoxia Infections Infectious Medicine Infektionsmedicin Klinisk medicin Medical and Health Sciences Medical research Medicin och hälsovetenskap Medicine MicroRNAs MicroRNAs - genetics Nanoparticles Obstetrics Obstetrics, Gynecology and Reproductive Medicine Oxidative stress Perfusion Placenta Plasma Pre-eclampsia Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Preeclampsia Pregnancy Reproduktionsmedicin och gynekologi Ribonucleic acid RNA Studies Surface markers Transmission electron microscopy Transport Vesicles - metabolism Transport Vesicles - ultrastructure Trophoblasts - metabolism Trophoblasts - ultrastructure Vesicles
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