Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model

Despite the significant amount of work being carried out to investigate the therapeutic potential of docosahexaenoic acid (DHA) in Alzheimer's disease (AD), the mechanism by which DHA affects amyloid-β precursor protein (AβPP)-induced metabolic changes has not been studied. To elucidate the met...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e90123-e90123
Hauptverfasser:	Bahety, Priti, Tan, Yee Min, Hong, Yanjun, Zhang, Luqi, Chan, Eric Chun Yong, Ee, Pui-Lai Rachel
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Animals Arachidonic acid Biology Biosynthesis Chemistry CHO Cells Cholesterol Citric acid Cricetulus Data analysis Data processing Discriminant analysis Docosahexaenoic acid Docosahexaenoic Acids - metabolism Docosahexaenoic Acids - pharmacology Docosahexaenoic Acids - therapeutic use Energy metabolism Fatty acids Gas chromatography Gas Chromatography-Mass Spectrometry Gene Expression Glycine Health aspects Health care Humans Inflammation Malic acid Mass spectrometry Mass spectroscopy Medicine Memory Metabolic Networks and Pathways - drug effects Metabolic pathways Metabolism Metabolites Metabolome Metabolomics Multivariate analysis Neurodegenerative diseases Neurology Neuroprotection Neurosciences Nutrition research Oxidative stress Pharmacy Principal components analysis Profiling Proteins Pyruvate Dehydrogenase Complex - metabolism Science Signal transduction Statistical analysis Statistical methods Succinic acid Tricarboxylic acid cycle Zymosterol
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