Adaptive optics-assisted identification of preferential erythrocyte aggregate pathways in the human retinal microvasculature
To characterize human parafoveal blood flow using adaptive optics scanning laser ophthalmoscopy (AO-SLO). In 5 normal subjects, erythrocyte aggregate distributions were analyzed on 3 different days. Erythrocyte aggregates were described as a "dark tail" in AO-SLO. The characteristics of th...
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| Veröffentlicht in: | PloS one 2014-02, Vol.9 (2), p.e89679-e89679 |
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| creator | Arichika, Shigeta Uji, Akihito Ooto, Sotaro Miyamoto, Kazuaki Yoshimura, Nagahisa |
| description | To characterize human parafoveal blood flow using adaptive optics scanning laser ophthalmoscopy (AO-SLO).
In 5 normal subjects, erythrocyte aggregate distributions were analyzed on 3 different days. Erythrocyte aggregates were described as a "dark tail" in AO-SLO. The characteristics of the pathways with dark tail flow in the parafovea were measured. Additionally, the tendency for dark tail flow before and after bifurcations was analyzed to study the blood flow in detail.
Average velocity in parent vessels with dark tail flow was 1.30±0.27 mm/s. Average velocity in daughter vessels with dark tail flow was 1.12±0.25 mm/s, and the average velocity of plasma gaps in daughter vessels without dark tail flow was 0.64±0.11 mm/s. Downstream from the bifurcations, the velocity in vessels with dark tail flow was higher than that in those without it (p |
| doi_str_mv | 10.1371/journal.pone.0089679 |
| format | Article |
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In 5 normal subjects, erythrocyte aggregate distributions were analyzed on 3 different days. Erythrocyte aggregates were described as a "dark tail" in AO-SLO. The characteristics of the pathways with dark tail flow in the parafovea were measured. Additionally, the tendency for dark tail flow before and after bifurcations was analyzed to study the blood flow in detail.
Average velocity in parent vessels with dark tail flow was 1.30±0.27 mm/s. Average velocity in daughter vessels with dark tail flow was 1.12±0.25 mm/s, and the average velocity of plasma gaps in daughter vessels without dark tail flow was 0.64±0.11 mm/s. Downstream from the bifurcations, the velocity in vessels with dark tail flow was higher than that in those without it (p<0.001), and the branching angles of vessels with dark tail flow were smaller than those of vessels without it (p<0.001).
Images from the AO-SLO noninvasively revealed pathways with and without dark tail flow in the human parafovea. Pathways with dark tail flow in the daughter vessels generally had faster flow and smaller bifurcation angles than daughter vessels without dark tail flow. Thus, AO-SLO is an instructive tool for analyzing retinal microcirculatory hemodynamics.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0089679</identifier><identifier>PMID: 24586959</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptive optics ; Average velocity ; Bifurcations ; Biology ; Blood ; Blood flow ; Blood Flow Velocity ; Blood pressure ; Blood vessels ; Diabetes ; Diabetic retinopathy ; Engineering ; Erythrocyte Aggregation ; Erythrocytes ; Family medical history ; Flow ; Hemodynamics ; Humans ; Lasers ; Medical imaging ; Medicine ; Microcirculation ; Microvasculature ; Microvessels ; Ophthalmoscopy - methods ; Optics ; Optics and Photonics ; Pathways ; Photoreceptors ; Retina ; Retinal Vessels - physiology ; Systemic diseases ; University graduates ; Velocity</subject><ispartof>PloS one, 2014-02, Vol.9 (2), p.e89679-e89679</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Arichika et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Arichika et al 2014 Arichika et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-dd7a4182e1db02e7dda91fb6d5343cc3743618e20e187defb75332f780d2f8793</citedby><cites>FETCH-LOGICAL-c758t-dd7a4182e1db02e7dda91fb6d5343cc3743618e20e187defb75332f780d2f8793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935927/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935927/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24586959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arichika, Shigeta</creatorcontrib><creatorcontrib>Uji, Akihito</creatorcontrib><creatorcontrib>Ooto, Sotaro</creatorcontrib><creatorcontrib>Miyamoto, Kazuaki</creatorcontrib><creatorcontrib>Yoshimura, Nagahisa</creatorcontrib><title>Adaptive optics-assisted identification of preferential erythrocyte aggregate pathways in the human retinal microvasculature</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To characterize human parafoveal blood flow using adaptive optics scanning laser ophthalmoscopy (AO-SLO).
In 5 normal subjects, erythrocyte aggregate distributions were analyzed on 3 different days. Erythrocyte aggregates were described as a "dark tail" in AO-SLO. The characteristics of the pathways with dark tail flow in the parafovea were measured. Additionally, the tendency for dark tail flow before and after bifurcations was analyzed to study the blood flow in detail.
Average velocity in parent vessels with dark tail flow was 1.30±0.27 mm/s. Average velocity in daughter vessels with dark tail flow was 1.12±0.25 mm/s, and the average velocity of plasma gaps in daughter vessels without dark tail flow was 0.64±0.11 mm/s. Downstream from the bifurcations, the velocity in vessels with dark tail flow was higher than that in those without it (p<0.001), and the branching angles of vessels with dark tail flow were smaller than those of vessels without it (p<0.001).
Images from the AO-SLO noninvasively revealed pathways with and without dark tail flow in the human parafovea. Pathways with dark tail flow in the daughter vessels generally had faster flow and smaller bifurcation angles than daughter vessels without dark tail flow. Thus, AO-SLO is an instructive tool for analyzing retinal microcirculatory hemodynamics.</description><subject>Adaptive optics</subject><subject>Average velocity</subject><subject>Bifurcations</subject><subject>Biology</subject><subject>Blood</subject><subject>Blood flow</subject><subject>Blood Flow Velocity</subject><subject>Blood pressure</subject><subject>Blood vessels</subject><subject>Diabetes</subject><subject>Diabetic retinopathy</subject><subject>Engineering</subject><subject>Erythrocyte Aggregation</subject><subject>Erythrocytes</subject><subject>Family medical history</subject><subject>Flow</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Lasers</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Microcirculation</subject><subject>Microvasculature</subject><subject>Microvessels</subject><subject>Ophthalmoscopy - methods</subject><subject>Optics</subject><subject>Optics and Photonics</subject><subject>Pathways</subject><subject>Photoreceptors</subject><subject>Retina</subject><subject>Retinal Vessels - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arichika, Shigeta</au><au>Uji, Akihito</au><au>Ooto, Sotaro</au><au>Miyamoto, Kazuaki</au><au>Yoshimura, Nagahisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adaptive optics-assisted identification of preferential erythrocyte aggregate pathways in the human retinal microvasculature</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-02-26</date><risdate>2014</risdate><volume>9</volume><issue>2</issue><spage>e89679</spage><epage>e89679</epage><pages>e89679-e89679</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To characterize human parafoveal blood flow using adaptive optics scanning laser ophthalmoscopy (AO-SLO).
In 5 normal subjects, erythrocyte aggregate distributions were analyzed on 3 different days. Erythrocyte aggregates were described as a "dark tail" in AO-SLO. The characteristics of the pathways with dark tail flow in the parafovea were measured. Additionally, the tendency for dark tail flow before and after bifurcations was analyzed to study the blood flow in detail.
Average velocity in parent vessels with dark tail flow was 1.30±0.27 mm/s. Average velocity in daughter vessels with dark tail flow was 1.12±0.25 mm/s, and the average velocity of plasma gaps in daughter vessels without dark tail flow was 0.64±0.11 mm/s. Downstream from the bifurcations, the velocity in vessels with dark tail flow was higher than that in those without it (p<0.001), and the branching angles of vessels with dark tail flow were smaller than those of vessels without it (p<0.001).
Images from the AO-SLO noninvasively revealed pathways with and without dark tail flow in the human parafovea. Pathways with dark tail flow in the daughter vessels generally had faster flow and smaller bifurcation angles than daughter vessels without dark tail flow. Thus, AO-SLO is an instructive tool for analyzing retinal microcirculatory hemodynamics.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24586959</pmid><doi>10.1371/journal.pone.0089679</doi><tpages>e89679</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptive optics Average velocity Bifurcations Biology Blood Blood flow Blood Flow Velocity Blood pressure Blood vessels Diabetes Diabetic retinopathy Engineering Erythrocyte Aggregation Erythrocytes Family medical history Flow Hemodynamics Humans Lasers Medical imaging Medicine Microcirculation Microvasculature Microvessels Ophthalmoscopy - methods Optics Optics and Photonics Pathways Photoreceptors Retina Retinal Vessels - physiology Systemic diseases University graduates Velocity |
| title | Adaptive optics-assisted identification of preferential erythrocyte aggregate pathways in the human retinal microvasculature |
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