RNA aptamer probes as optical imaging agents for the detection of amyloid plaques

Optical imaging using multiphoton microscopy and whole body near infrared imaging has become a routine part of biomedical research. However, optical imaging methods rely on the availability of either small molecule reporters or genetically encoded fluorescent proteins, which are challenging and time...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e89901-e89901
Hauptverfasser:	Farrar, Christian T, William, Christopher M, Hudry, Eloise, Hashimoto, Tadafumi, Hyman, Bradley T
Format:	Artikel
Sprache:	eng
Schlagworte:	Agents (artificial intelligence) Alzheimer Disease - diagnosis Alzheimer Disease - pathology Alzheimer's disease Animals Antibodies Aptamers Aptamers, Nucleotide - genetics Base Pairing Base Sequence Binding Biochemistry Biology Biomedical materials Blood-brain barrier Blotting, Western Brain Coding Cores Deoxyribonucleic acid Disease DNA DNA probes Fluorescence Genetic code Genetic engineering Halos Hospitals Humans Immunoblotting Immunoglobulins Infrared imaging Ligands Medical imaging Medical research Medical schools Medicine Mice Mice, Transgenic Microscopy Molecular Sequence Data Neuroimaging Neurology NMR Nuclear magnetic resonance Optical Imaging - methods Optical properties Peptides Physics Plaque, Amyloid - ultrastructure Plaques Presenilin 1 Probes Proteins Ribonucleic acid RNA RNA probes RNA Probes - genetics Rodents Senile plaques Tomography Transgenic animals Transgenic mice
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