Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis
MiRNAs are important regulators of different biological processes, including tumorigenesis. MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of inc...
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| Veröffentlicht in: | PloS one 2014-02, Vol.9 (2), p.e89223 |
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| description | MiRNAs are important regulators of different biological processes, including tumorigenesis. MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-210 expression in the prognosis of indicated cancers.
The present systematic review and meta-analysis of 16 researches included 1809 patients with 7 different types of cancers from 7 countries, and aimed to explore the association between miR-210 expression and the survival of cancer patients. Over-expression of miR-210 may predict poor overall survival (OS, HR = 1.33, 95% CI: 0.85-2.09, P = 0.210), but the effect was not significant. While the predictive effect on disease-free survival (DFS, HR = 1.89, 95% CI: 1.30-2.74, P = 0.001), progression-free survival (PFS, HR = 1.20, 95% CI: 1.05-1.38, P = 0.007) and relapse-free survival(RFS, HR = 4.42, 95% CI: 2.14-9.15, P = 0.000) for patients with breast cancer, primary head and neck squamous cell carcinoma (HNSCC), renal cancer, soft-tissue sarcoma, pediatric osteosarcoma, bladder cancer or glioblastoma was certain. Subgroup analysis showed the limited predictive effect of over-expressed miR-210 on breast cancer OS (HR = 1.63, 95% CI: 0.47-5.67, P = 0.443), breast cancer DFS (HR = 2.03, 95% CI: 0.90-4.57, P = 0.088), sarcoma OS (HR = 1.24, 95% CI: 0.20-7.89, P = 0.818) and renal cancer OS (HR = 1.16, 95% CI: 0.27-4.94, P = 0.842).
This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant. |
| doi_str_mv | 10.1371/journal.pone.0089223 |
| format | Article |
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The present systematic review and meta-analysis of 16 researches included 1809 patients with 7 different types of cancers from 7 countries, and aimed to explore the association between miR-210 expression and the survival of cancer patients. Over-expression of miR-210 may predict poor overall survival (OS, HR = 1.33, 95% CI: 0.85-2.09, P = 0.210), but the effect was not significant. While the predictive effect on disease-free survival (DFS, HR = 1.89, 95% CI: 1.30-2.74, P = 0.001), progression-free survival (PFS, HR = 1.20, 95% CI: 1.05-1.38, P = 0.007) and relapse-free survival(RFS, HR = 4.42, 95% CI: 2.14-9.15, P = 0.000) for patients with breast cancer, primary head and neck squamous cell carcinoma (HNSCC), renal cancer, soft-tissue sarcoma, pediatric osteosarcoma, bladder cancer or glioblastoma was certain. Subgroup analysis showed the limited predictive effect of over-expressed miR-210 on breast cancer OS (HR = 1.63, 95% CI: 0.47-5.67, P = 0.443), breast cancer DFS (HR = 2.03, 95% CI: 0.90-4.57, P = 0.088), sarcoma OS (HR = 1.24, 95% CI: 0.20-7.89, P = 0.818) and renal cancer OS (HR = 1.16, 95% CI: 0.27-4.94, P = 0.842).
This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0089223</identifier><identifier>PMID: 24586608</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Angiogenesis ; Biocompatibility ; Biological activity ; Biology ; Biomarkers, Tumor - genetics ; Biomedical materials ; Bladder ; Bladder cancer ; Breast cancer ; Cancer ; Cancer patients ; Cancer research ; Cancer therapies ; Cell growth ; Development and progression ; Disease prevention ; DNA repair ; Gene expression ; Glioblastoma ; Head ; Head & neck cancer ; Head and neck cancer ; Humans ; Hypoxia ; Kidney cancer ; Kinases ; Medical prognosis ; Medical research ; Medicine ; Meta-analysis ; MicroRNAs ; MicroRNAs - genetics ; Neoplasms - genetics ; Neoplasms - mortality ; Nephrology ; Osteosarcoma ; Overexpression ; Patient outcomes ; Patients ; Preventive medicine ; Prognosis ; Regulators ; Renal cell carcinoma ; Sarcoma ; Squamous cell carcinoma ; Statistical analysis ; Studies ; Survival ; Survival Rate ; Systematic review ; Toxicology ; Tumorigenesis ; Urinary bladder</subject><ispartof>PloS one, 2014-02, Vol.9 (2), p.e89223</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Wang et al 2014 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-10dbb4ff4161c97af76d34fbb4a7d113282dc722fd891d1ae630bc56f1e677a83</citedby><cites>FETCH-LOGICAL-c758t-10dbb4ff4161c97af76d34fbb4a7d113282dc722fd891d1ae630bc56f1e677a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930667/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930667/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2930,23873,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24586608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lebedeva, Irina V.</contributor><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Zhao, Jiqing</creatorcontrib><creatorcontrib>Shi, Mengjing</creatorcontrib><creatorcontrib>Ding, Yu</creatorcontrib><creatorcontrib>Sun, Huiqin</creatorcontrib><creatorcontrib>Yuan, Fahuan</creatorcontrib><creatorcontrib>Zou, Zhongmin</creatorcontrib><title>Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>MiRNAs are important regulators of different biological processes, including tumorigenesis. MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-210 expression in the prognosis of indicated cancers.
The present systematic review and meta-analysis of 16 researches included 1809 patients with 7 different types of cancers from 7 countries, and aimed to explore the association between miR-210 expression and the survival of cancer patients. Over-expression of miR-210 may predict poor overall survival (OS, HR = 1.33, 95% CI: 0.85-2.09, P = 0.210), but the effect was not significant. While the predictive effect on disease-free survival (DFS, HR = 1.89, 95% CI: 1.30-2.74, P = 0.001), progression-free survival (PFS, HR = 1.20, 95% CI: 1.05-1.38, P = 0.007) and relapse-free survival(RFS, HR = 4.42, 95% CI: 2.14-9.15, P = 0.000) for patients with breast cancer, primary head and neck squamous cell carcinoma (HNSCC), renal cancer, soft-tissue sarcoma, pediatric osteosarcoma, bladder cancer or glioblastoma was certain. Subgroup analysis showed the limited predictive effect of over-expressed miR-210 on breast cancer OS (HR = 1.63, 95% CI: 0.47-5.67, P = 0.443), breast cancer DFS (HR = 2.03, 95% CI: 0.90-4.57, P = 0.088), sarcoma OS (HR = 1.24, 95% CI: 0.20-7.89, P = 0.818) and renal cancer OS (HR = 1.16, 95% CI: 0.27-4.94, P = 0.842).
This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant.</description><subject>Analysis</subject><subject>Angiogenesis</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Biology</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomedical materials</subject><subject>Bladder</subject><subject>Bladder cancer</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Cell growth</subject><subject>Development and progression</subject><subject>Disease prevention</subject><subject>DNA repair</subject><subject>Gene expression</subject><subject>Glioblastoma</subject><subject>Head</subject><subject>Head & neck cancer</subject><subject>Head and neck cancer</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Kidney cancer</subject><subject>Kinases</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Meta-analysis</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - mortality</subject><subject>Nephrology</subject><subject>Osteosarcoma</subject><subject>Overexpression</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Preventive medicine</subject><subject>Prognosis</subject><subject>Regulators</subject><subject>Renal cell carcinoma</subject><subject>Sarcoma</subject><subject>Squamous cell carcinoma</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Systematic review</subject><subject>Toxicology</subject><subject>Tumorigenesis</subject><subject>Urinary bladder</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L00AYhYMo7lr9B6IDguBF6nwkmcQLYVlWLSwsrB-3w9v5aKckmTozqdt_79RmlwYUJBcZTp735M3JybKXBM8J4-T9xg2-h3a-db2eY1w3lLJH2TlpGM0ritnjk_NZ9iyEDcYlq6vqaXZGizIdcH2euatW7yBqhfTd1usQrOuRM6iztzklGCVNWRkD2jrnURj8zu6gPRASeqk92kK0uo_hAwIU9iHqLgkSeb2z-heCXqFOR8ghrboPNjzPnhhog34x3mfZ909X3y6_5Nc3nxeXF9e55GUdc4LVclkYU5CKyIaD4ZVihUkacEUIozVVklNqVN0QRUBXDC9lWRmiK86hZrPs9dF327ogxqyCICXGvKQFPhCLI6EcbMTW2w78Xjiw4o_g_EqAT5_SatFU0mBdU1oVukgrAKWYN6yQZaGMKSF5fRzfNiw7rWQKxEM7MZ0-6e1arNxOsIbhquLJ4M1o4N3PQYf4j5VHagVpK9sbl8xkZ4MUFwWveVMffvEsm_-FSpfSnZWpLcYmfTLwbjKQmKjv4gqGEMTi6-3_szc_puzbE3atoY3r4Nohpo6FKVgcQeldCF6bh-QIFoey36chDmUXY9nT2KvT1B-G7tvNfgPtOvrq</recordid><startdate>20140220</startdate><enddate>20140220</enddate><creator>Wang, Jian</creator><creator>Zhao, Jiqing</creator><creator>Shi, Mengjing</creator><creator>Ding, Yu</creator><creator>Sun, Huiqin</creator><creator>Yuan, Fahuan</creator><creator>Zou, Zhongmin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140220</creationdate><title>Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis</title><author>Wang, Jian ; Zhao, Jiqing ; Shi, Mengjing ; Ding, Yu ; Sun, Huiqin ; Yuan, Fahuan ; Zou, Zhongmin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-10dbb4ff4161c97af76d34fbb4a7d113282dc722fd891d1ae630bc56f1e677a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis</topic><topic>Angiogenesis</topic><topic>Biocompatibility</topic><topic>Biological activity</topic><topic>Biology</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomedical materials</topic><topic>Bladder</topic><topic>Bladder cancer</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>Cell growth</topic><topic>Development and progression</topic><topic>Disease prevention</topic><topic>DNA repair</topic><topic>Gene expression</topic><topic>Glioblastoma</topic><topic>Head</topic><topic>Head & neck cancer</topic><topic>Head and neck cancer</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Kidney cancer</topic><topic>Kinases</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Meta-analysis</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - mortality</topic><topic>Nephrology</topic><topic>Osteosarcoma</topic><topic>Overexpression</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Preventive medicine</topic><topic>Prognosis</topic><topic>Regulators</topic><topic>Renal cell carcinoma</topic><topic>Sarcoma</topic><topic>Squamous cell carcinoma</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Systematic review</topic><topic>Toxicology</topic><topic>Tumorigenesis</topic><topic>Urinary bladder</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Zhao, Jiqing</creatorcontrib><creatorcontrib>Shi, Mengjing</creatorcontrib><creatorcontrib>Ding, Yu</creatorcontrib><creatorcontrib>Sun, Huiqin</creatorcontrib><creatorcontrib>Yuan, Fahuan</creatorcontrib><creatorcontrib>Zou, Zhongmin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-210 expression in the prognosis of indicated cancers.
The present systematic review and meta-analysis of 16 researches included 1809 patients with 7 different types of cancers from 7 countries, and aimed to explore the association between miR-210 expression and the survival of cancer patients. Over-expression of miR-210 may predict poor overall survival (OS, HR = 1.33, 95% CI: 0.85-2.09, P = 0.210), but the effect was not significant. While the predictive effect on disease-free survival (DFS, HR = 1.89, 95% CI: 1.30-2.74, P = 0.001), progression-free survival (PFS, HR = 1.20, 95% CI: 1.05-1.38, P = 0.007) and relapse-free survival(RFS, HR = 4.42, 95% CI: 2.14-9.15, P = 0.000) for patients with breast cancer, primary head and neck squamous cell carcinoma (HNSCC), renal cancer, soft-tissue sarcoma, pediatric osteosarcoma, bladder cancer or glioblastoma was certain. Subgroup analysis showed the limited predictive effect of over-expressed miR-210 on breast cancer OS (HR = 1.63, 95% CI: 0.47-5.67, P = 0.443), breast cancer DFS (HR = 2.03, 95% CI: 0.90-4.57, P = 0.088), sarcoma OS (HR = 1.24, 95% CI: 0.20-7.89, P = 0.818) and renal cancer OS (HR = 1.16, 95% CI: 0.27-4.94, P = 0.842).
This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24586608</pmid><doi>10.1371/journal.pone.0089223</doi><tpages>e89223</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1500752408 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Angiogenesis Biocompatibility Biological activity Biology Biomarkers, Tumor - genetics Biomedical materials Bladder Bladder cancer Breast cancer Cancer Cancer patients Cancer research Cancer therapies Cell growth Development and progression Disease prevention DNA repair Gene expression Glioblastoma Head Head & neck cancer Head and neck cancer Humans Hypoxia Kidney cancer Kinases Medical prognosis Medical research Medicine Meta-analysis MicroRNAs MicroRNAs - genetics Neoplasms - genetics Neoplasms - mortality Nephrology Osteosarcoma Overexpression Patient outcomes Patients Preventive medicine Prognosis Regulators Renal cell carcinoma Sarcoma Squamous cell carcinoma Statistical analysis Studies Survival Survival Rate Systematic review Toxicology Tumorigenesis Urinary bladder |
| title | Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T09%3A01%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Elevated%20expression%20of%20miR-210%20predicts%20poor%20survival%20of%20cancer%20patients:%20a%20systematic%20review%20and%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Wang,%20Jian&rft.date=2014-02-20&rft.volume=9&rft.issue=2&rft.spage=e89223&rft.pages=e89223-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0089223&rft_dat=%3Cgale_plos_%3EA478798005%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1500752408&rft_id=info:pmid/24586608&rft_galeid=A478798005&rft_doaj_id=oai_doaj_org_article_96cf0e82264e4b4aa2207934c54dff5a&rfr_iscdi=true |