Genetic polymorphism of apolipoprotein A5 gene and susceptibility to type 2 diabetes mellitus: a meta-analysis of 15,137 subjects
Several studies have investigated whether the polymorphism in the apolipoprotein A5 (APOA5) is associated with type 2 diabetes mellitus (T2DM) risk. However, those studies have produced inconsistent results. The purpose of this study was to investigate whether the APOA5 -1131T/C polymorphism (rs6627...
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| description | Several studies have investigated whether the polymorphism in the apolipoprotein A5 (APOA5) is associated with type 2 diabetes mellitus (T2DM) risk. However, those studies have produced inconsistent results. The purpose of this study was to investigate whether the APOA5 -1131T/C polymorphism (rs662799) confers significant susceptibility to T2DM using a meta-analysis.
PubMed, Embase, Web of Science, Cochrane database, CBMdisc, CNKI and Google Scholar were searched to get the genetic association studies. All statistical analyses were done with Stata 11.0.
A total of 19 studies included 4,767 T2DM cases and 10,370 controls (four studies involving 555 T2DM cases and 2958 controls were performed among Europeans and 15 studies involving 4212 T2DM cases and 7412 controls were performed among Asians) were combined showing significant association between the APOA5 -1131T/C polymorphism and T2DM risk (for C allele vs. T allele: OR = 1.28, 95% CI = 1.17-1.40, p |
| doi_str_mv | 10.1371/journal.pone.0089167 |
| format | Article |
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PubMed, Embase, Web of Science, Cochrane database, CBMdisc, CNKI and Google Scholar were searched to get the genetic association studies. All statistical analyses were done with Stata 11.0.
A total of 19 studies included 4,767 T2DM cases and 10,370 controls (four studies involving 555 T2DM cases and 2958 controls were performed among Europeans and 15 studies involving 4212 T2DM cases and 7412 controls were performed among Asians) were combined showing significant association between the APOA5 -1131T/C polymorphism and T2DM risk (for C allele vs. T allele: OR = 1.28, 95% CI = 1.17-1.40, p<0.00001; for C/C vs. T/T: OR = 1.57, 95% CI = 1.35-1.83, p<0.00001; for C/C vs. T/C+T/T: OR = 1.36, 95% CI = 1.18-1.57, p<0.0001; for C/C+T/C vs. T/T: OR = 1.32, 95% CI = 1.16-1.51, p<0.0001). In the subgroup analysis by ethnicity, significant association was also found among Asians (for C allele vs. T allele: OR = 1.31, 95% CI = 1.22-1.40, p<0.00001; for C/C vs. T/T: OR = 1.61, 95% CI = 1.38-1.88, p<0.00001; for C/C vs. T/C+T/T: OR = 1.39, 95% CI = 1.20-1.61, p<0.0001; for C/C+T/C vs. T/T: OR = 1.42, 95% CI = 1.25-1.62, p<0.00001). However, no significant association was found between the APOA5 -1131T/C polymorphism and T2DM risk among Europeans.
The present meta-analysis suggests that the APOA5 -1131T/C polymorphism is associated with an increased T2DM risk in Asian population.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0089167</identifier><identifier>PMID: 24586566</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alleles ; Alzheimer's disease ; Analysis ; Apolipoprotein A-V ; Apolipoproteins ; Apolipoproteins A - genetics ; Asian Continental Ancestry Group - genetics ; Asian Continental Ancestry Group - statistics & numerical data ; Biology ; Cardiovascular disease ; Case-Control Studies ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes Mellitus, Type 2 - genetics ; Disease susceptibility ; Epidemiology ; Ethnicity ; European Continental Ancestry Group - genetics ; European Continental Ancestry Group - statistics & numerical data ; Gene polymorphism ; Genetic aspects ; Genetic Heterogeneity ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genomes ; Health risks ; Hospitals ; Humans ; Medical ethics ; Medicine ; Meta-analysis ; Metabolic syndrome ; Minority & ethnic groups ; Polymorphism ; Polymorphism, Single Nucleotide ; Population ; Population (statistical) ; Quality ; Risk ; Scientific papers ; Search engines ; Statistical analysis ; Studies ; Type 2 diabetes</subject><ispartof>PloS one, 2014-02, Vol.9 (2), p.e89167-e89167</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Yin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Yin et al 2014 Yin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-5fbaf9ca9099049aff9706cfe239600d8ad152384649a5e7137fbe995dd9669f3</citedby><cites>FETCH-LOGICAL-c758t-5fbaf9ca9099049aff9706cfe239600d8ad152384649a5e7137fbe995dd9669f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929635/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929635/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2101,2927,23865,27923,27924,53790,53792,79471,79472</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24586566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Katoh, Masaru</contributor><creatorcontrib>Yin, Yan-Wei</creatorcontrib><creatorcontrib>Sun, Qian-Qian</creatorcontrib><creatorcontrib>Wang, Pei-Jian</creatorcontrib><creatorcontrib>Qiao, Li</creatorcontrib><creatorcontrib>Hu, Ai-Min</creatorcontrib><creatorcontrib>Liu, Hong-Li</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Hou, Zhi-Zhen</creatorcontrib><title>Genetic polymorphism of apolipoprotein A5 gene and susceptibility to type 2 diabetes mellitus: a meta-analysis of 15,137 subjects</title><title>PloS one</title><addtitle>PLoS One</addtitle><description><![CDATA[Several studies have investigated whether the polymorphism in the apolipoprotein A5 (APOA5) is associated with type 2 diabetes mellitus (T2DM) risk. However, those studies have produced inconsistent results. The purpose of this study was to investigate whether the APOA5 -1131T/C polymorphism (rs662799) confers significant susceptibility to T2DM using a meta-analysis.
PubMed, Embase, Web of Science, Cochrane database, CBMdisc, CNKI and Google Scholar were searched to get the genetic association studies. All statistical analyses were done with Stata 11.0.
A total of 19 studies included 4,767 T2DM cases and 10,370 controls (four studies involving 555 T2DM cases and 2958 controls were performed among Europeans and 15 studies involving 4212 T2DM cases and 7412 controls were performed among Asians) were combined showing significant association between the APOA5 -1131T/C polymorphism and T2DM risk (for C allele vs. T allele: OR = 1.28, 95% CI = 1.17-1.40, p<0.00001; for C/C vs. T/T: OR = 1.57, 95% CI = 1.35-1.83, p<0.00001; for C/C vs. T/C+T/T: OR = 1.36, 95% CI = 1.18-1.57, p<0.0001; for C/C+T/C vs. T/T: OR = 1.32, 95% CI = 1.16-1.51, p<0.0001). In the subgroup analysis by ethnicity, significant association was also found among Asians (for C allele vs. T allele: OR = 1.31, 95% CI = 1.22-1.40, p<0.00001; for C/C vs. T/T: OR = 1.61, 95% CI = 1.38-1.88, p<0.00001; for C/C vs. T/C+T/T: OR = 1.39, 95% CI = 1.20-1.61, p<0.0001; for C/C+T/C vs. T/T: OR = 1.42, 95% CI = 1.25-1.62, p<0.00001). However, no significant association was found between the APOA5 -1131T/C polymorphism and T2DM risk among Europeans.
The present meta-analysis suggests that the APOA5 -1131T/C polymorphism is associated with an increased T2DM risk in Asian population.]]></description><subject>Alleles</subject><subject>Alzheimer's disease</subject><subject>Analysis</subject><subject>Apolipoprotein A-V</subject><subject>Apolipoproteins</subject><subject>Apolipoproteins A - genetics</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Asian Continental Ancestry Group - statistics & numerical data</subject><subject>Biology</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - ethnology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Disease susceptibility</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>European Continental Ancestry Group - genetics</subject><subject>European Continental Ancestry Group - statistics & numerical data</subject><subject>Gene polymorphism</subject><subject>Genetic aspects</subject><subject>Genetic Heterogeneity</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genomes</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Medical ethics</subject><subject>Medicine</subject><subject>Meta-analysis</subject><subject>Metabolic syndrome</subject><subject>Minority & ethnic groups</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Population (statistical)</subject><subject>Quality</subject><subject>Risk</subject><subject>Scientific papers</subject><subject>Search engines</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Type 2 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polymorphism of apolipoprotein A5 gene and susceptibility to type 2 diabetes mellitus: a meta-analysis of 15,137 subjects</title><author>Yin, Yan-Wei ; Sun, Qian-Qian ; Wang, Pei-Jian ; Qiao, Li ; Hu, Ai-Min ; Liu, Hong-Li ; Wang, Qi ; Hou, Zhi-Zhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-5fbaf9ca9099049aff9706cfe239600d8ad152384649a5e7137fbe995dd9669f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alleles</topic><topic>Alzheimer's disease</topic><topic>Analysis</topic><topic>Apolipoprotein A-V</topic><topic>Apolipoproteins</topic><topic>Apolipoproteins A - genetics</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Asian Continental Ancestry Group - statistics & numerical data</topic><topic>Biology</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Diabetes</topic><topic>Diabetes 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engines</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Yan-Wei</creatorcontrib><creatorcontrib>Sun, Qian-Qian</creatorcontrib><creatorcontrib>Wang, Pei-Jian</creatorcontrib><creatorcontrib>Qiao, Li</creatorcontrib><creatorcontrib>Hu, Ai-Min</creatorcontrib><creatorcontrib>Liu, Hong-Li</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Hou, Zhi-Zhen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Yan-Wei</au><au>Sun, Qian-Qian</au><au>Wang, Pei-Jian</au><au>Qiao, Li</au><au>Hu, Ai-Min</au><au>Liu, Hong-Li</au><au>Wang, Qi</au><au>Hou, Zhi-Zhen</au><au>Katoh, Masaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic polymorphism of apolipoprotein A5 gene and susceptibility to type 2 diabetes mellitus: a meta-analysis of 15,137 subjects</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-02-19</date><risdate>2014</risdate><volume>9</volume><issue>2</issue><spage>e89167</spage><epage>e89167</epage><pages>e89167-e89167</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract><![CDATA[Several studies have investigated whether the polymorphism in the apolipoprotein A5 (APOA5) is associated with type 2 diabetes mellitus (T2DM) risk. However, those studies have produced inconsistent results. The purpose of this study was to investigate whether the APOA5 -1131T/C polymorphism (rs662799) confers significant susceptibility to T2DM using a meta-analysis.
PubMed, Embase, Web of Science, Cochrane database, CBMdisc, CNKI and Google Scholar were searched to get the genetic association studies. All statistical analyses were done with Stata 11.0.
A total of 19 studies included 4,767 T2DM cases and 10,370 controls (four studies involving 555 T2DM cases and 2958 controls were performed among Europeans and 15 studies involving 4212 T2DM cases and 7412 controls were performed among Asians) were combined showing significant association between the APOA5 -1131T/C polymorphism and T2DM risk (for C allele vs. T allele: OR = 1.28, 95% CI = 1.17-1.40, p<0.00001; for C/C vs. T/T: OR = 1.57, 95% CI = 1.35-1.83, p<0.00001; for C/C vs. T/C+T/T: OR = 1.36, 95% CI = 1.18-1.57, p<0.0001; for C/C+T/C vs. T/T: OR = 1.32, 95% CI = 1.16-1.51, p<0.0001). In the subgroup analysis by ethnicity, significant association was also found among Asians (for C allele vs. T allele: OR = 1.31, 95% CI = 1.22-1.40, p<0.00001; for C/C vs. T/T: OR = 1.61, 95% CI = 1.38-1.88, p<0.00001; for C/C vs. T/C+T/T: OR = 1.39, 95% CI = 1.20-1.61, p<0.0001; for C/C+T/C vs. T/T: OR = 1.42, 95% CI = 1.25-1.62, p<0.00001). However, no significant association was found between the APOA5 -1131T/C polymorphism and T2DM risk among Europeans.
The present meta-analysis suggests that the APOA5 -1131T/C polymorphism is associated with an increased T2DM risk in Asian population.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24586566</pmid><doi>10.1371/journal.pone.0089167</doi><tpages>e89167</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-02, Vol.9 (2), p.e89167-e89167 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1500410388 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alleles Alzheimer's disease Analysis Apolipoprotein A-V Apolipoproteins Apolipoproteins A - genetics Asian Continental Ancestry Group - genetics Asian Continental Ancestry Group - statistics & numerical data Biology Cardiovascular disease Case-Control Studies Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Disease susceptibility Epidemiology Ethnicity European Continental Ancestry Group - genetics European Continental Ancestry Group - statistics & numerical data Gene polymorphism Genetic aspects Genetic Heterogeneity Genetic polymorphisms Genetic Predisposition to Disease Genomes Health risks Hospitals Humans Medical ethics Medicine Meta-analysis Metabolic syndrome Minority & ethnic groups Polymorphism Polymorphism, Single Nucleotide Population Population (statistical) Quality Risk Scientific papers Search engines Statistical analysis Studies Type 2 diabetes |
| title | Genetic polymorphism of apolipoprotein A5 gene and susceptibility to type 2 diabetes mellitus: a meta-analysis of 15,137 subjects |
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