Aberrant bone density in aging mice lacking the adenosine transporter ENT1

Adenosine is known to regulate bone production and resorption in humans and mice. Type 1 equilibrative nucleoside transporter (ENT1) is responsible for the majority of adenosine transport across the plasma membrane and is ubiquitously expressed in both humans and mice. However, the contribution of E...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e88818
Hauptverfasser:	Hinton, David J, McGee-Lawrence, Meghan E, Lee, Moonnoh R, Kwong, Hoi K, Westendorf, Jennifer J, Choi, Doo-Sup
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Acid phosphatase Acid phosphatase (tartrate-resistant) Acid resistance Adenosine Aging Aging - genetics Aging - physiology Alcohol Animals Biocompatibility Biology Biomedical materials Body Weight - genetics Body Weight - physiology Bone density Bone Density - genetics Bone Density - physiology Bone diseases Bone mineral density Bone remodeling Bone resorption Bone surgery Bone turnover Bones CAT scans Chemical compounds Computed tomography Dual energy X-ray absorptiometry Energy consumption Equilibrative Nucleoside Transporter 1 - genetics Ethanol Experiments Femur Femur - cytology Femur - growth & development Femur - physiology Gene Deletion Gene expression Gene Expression Regulation Health aspects Homeostasis Locomotor activity Lumbar Vertebrae - cytology Lumbar Vertebrae - growth & development Lumbar Vertebrae - physiology Mechanical properties Medicine Mice Mineralization Motor Activity - genetics Motor Activity - physiology Neurobiology Neurosciences Nucleoside transporter Organ Size - genetics Organ Size - physiology Orthopedics Osteoclasts - cytology Osteoclasts - metabolism Osteoporosis Pharmacology RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Rotarod Performance Test Senescence Signaling Spine Spine (lumbar) Tomography Vertebra Vertebrae
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