Red blood cell invasion by Plasmodium vivax: structural basis for DBP engagement of DARC

Plasmodium parasites use specialized ligands which bind to red blood cell (RBC) receptors during invasion. Defining the mechanism of receptor recognition is essential for the design of interventions against malaria. Here, we present the structural basis for Duffy antigen (DARC) engagement by P. viva...

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Veröffentlicht in:	PLoS pathogens 2014-01, Vol.10 (1), p.e1003869-e1003869
Hauptverfasser:	Batchelor, Joseph D, Malpede, Brian M, Omattage, Natalie S, DeKoster, Gregory T, Henzler-Wildman, Katherine A, Tolia, Niraj H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antigens, Protozoan - chemistry Antigens, Protozoan - genetics Antigens, Protozoan - immunology Binding sites Binding sites (Biochemistry) Biology Biomedical research Blood Cell Line Chemokines Duffy Blood-Group System - chemistry Duffy Blood-Group System - genetics Duffy Blood-Group System - immunology Erythrocytes Erythrocytes - chemistry Erythrocytes - immunology Erythrocytes - parasitology Genotype & phenotype Health aspects Host-parasite relationships Humans Immune Evasion Ligands Malaria, Vivax - genetics Malaria, Vivax - immunology Medicine Microbiological research Parasites Plasmodium Plasmodium vivax - chemistry Plasmodium vivax - immunology Plasmodium vivax - metabolism Point Mutation Protein Binding Proteins Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - immunology Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Structure-Activity Relationship Studies
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