Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes

The AMPK-Sirt1 pathway is an important regulator of energy metabolism and therefore a potential target for prevention and therapy of metabolic diseases. We recently demonstrated leucine and its metabolite β-hydroxy-β-methylbutyrate (HMB) to synergize with low-dose resveratrol (200 nM) to activate si...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e89166-e89166
Hauptverfasser:	Bruckbauer, Antje, Zemel, Michael B
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Acids Adipocytes Adipocytes - drug effects Adipocytes - metabolism Amino acids AMP-Activated Protein Kinases - antagonists & inhibitors AMP-Activated Protein Kinases - metabolism Analysis Animals Antibiotics Bioavailability Biology Biosynthesis Caffeic Acids - pharmacology Chemistry Chlorogenic Acid - pharmacology Diabetes Ellagic acid Ellagic Acid - pharmacology Energy metabolism Enzymes Epigallocatechin gallate Fatty acids Fatty Acids - metabolism Humans Hydroxycinnamic acid Insulin Kinases Kinetics Leucine Leucine - pharmacology Mammals Medicine Metabolic disorders Metabolism Metabolites Mice Muscle Cells - drug effects Muscle Cells - metabolism Muscles Musculoskeletal system Myotubes NAD NAD - pharmacology Oral administration Oxidation Oxidation-Reduction - drug effects Penicillin Phosphodiesterase Inhibitors - pharmacology Physiological aspects Polyphenols Polyphenols - pharmacology Protein Kinase Inhibitors - pharmacology R&D Research & development Resveratrol Signaling SIRT1 protein Sirtuin 1 - antagonists & inhibitors Sirtuin 1 - metabolism Stilbenes - pharmacology Studies Synergism Synergistic effect Synergistic effects Valerates - pharmacology Xanthines - pharmacology
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