Decreased peripheral natural killer cells activity in the immune activated stage of chronic hepatitis B

The natural course of chronic hepatitis B virus (HBV) infection is characterized by different immune responses, ranging from immune tolerant (IT) to immune activated (IA) stages. In our study, we investigated the natural killer (NK) cells activity in patients at different immunological stages of chr...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e86927-e86927
Hauptverfasser:	Li, Yuan, Wang, Jiu-Jun, Gao, Shan, Liu, Qian, Bai, Jia, Zhao, Xue-Qi, Hao, You-Hua, Ding, Hong-Hui, Zhu, Fan, Yang, Dong-Liang, Zhao, Xi-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Analysis Biological response modifiers Biology Blood Chronic infection Cytokines Cytometry Cytotoxicity Cytotoxicity, Immunologic Development and progression DNA, Viral - blood Flow cytometry Gastroenterology Health aspects Hepatitis Hepatitis B Hepatitis B e antigen Hepatitis B virus - immunology Hepatitis B virus - physiology Hepatitis B, Chronic - blood Hepatitis B, Chronic - immunology Hepatitis B, Chronic - pathology Hepatitis B, Chronic - virology Hepatology Hospitals Humans Immune response Immunity - immunology Immunology Infection Infections Infectious diseases Inflammation Interferon Interferon-gamma - metabolism Killer cells Killer Cells, Natural - immunology Liver - pathology Liver - virology Liver diseases Lymphocyte Subsets - immunology Lymphocytes Medical research Medicine Natural killer cells NKG2 antigen Pathogenesis Patients Peripheral blood Receptors, Immunologic - metabolism Science T cell receptors T-Lymphocytes - immunology Toxicity Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Virus Replication Viruses γ-Interferon
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