Acute morphine treatments alleviate tremor in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys

Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder associated with decreased striatal dopamine levels. Morphine has been found to elevate dopamine levels, which indicates a potential therapeutic effect in PD treatment that has not been investigated previously. To e...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e88404
Hauptverfasser:	Yan, Ting, Rizak, Joshua Dominic, Yang, ShangChuan, Li, Hao, Huang, Baihui, Ma, Yuanye, Hu, Xintian
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Acute effects Animal behavior Animals Behavior Behavior, Animal - drug effects Biological effects Biology Biomedical research Brain research Dihydroxyphenylalanine Dopamine Health aspects Hypokinesia - drug therapy Hypokinesia - physiopathology Laboratories Levodopa Levodopa - administration & dosage Levodopa - pharmacology Levodopa - therapeutic use Macaca mulatta - physiology Male Medicine Monkeys Monkeys & apes Morphine Morphine - administration & dosage Morphine - pharmacology Morphine - therapeutic use Motor Activity - drug effects Movement disorders MPTP Narcotics Neostriatum Nervous system diseases Neurodegenerative diseases Neurons Neurosciences Nitric oxide Parkinson Disease - drug therapy Parkinson Disease - physiopathology Parkinson's disease Postural Balance - drug effects Rodents Science Studies Tremor Tremor - drug therapy Tremor - physiopathology Zoology
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