High glucose induces podocyte injury via enhanced (pro)renin receptor-Wnt-β-catenin-snail signaling pathway

(Pro)renin receptor (PRR) expression is upregulated in diabetes. We hypothesized that PRR contributes to podocyte injury via activation of Wnt-β-catenin-snail signaling pathway. Mouse podocytes were cultured in normal (5 mM) or high (25 mM) D-glucose for 3 days. Compared to normal glucose, high gluc...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e89233
Hauptverfasser:	Li, Caixia, Siragy, Helmy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Albumin Animals beta Catenin - genetics beta Catenin - metabolism Biology Blotting, Western Cancer Cell adhesion & migration Cells, Cultured Confocal microscopy Cytoskeleton Diabetes Diabetes mellitus Endocrinology Fluorescent Antibody Technique Gene expression Glucose Glucose - pharmacology Hyperglycemia Immunoenzyme Techniques Injuries Kidney diseases Medicine Membrane permeability Metabolism Mice Microscopy mRNA Permeability Podocytes - drug effects Podocytes - metabolism Podocytes - pathology Prorenin Receptor Protein expression Proteins Real time Real-Time Polymerase Chain Reaction Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Renin Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Rodents Signal transduction Signal Transduction - drug effects Signaling siRNA Snail Family Transcription Factors Sweetening Agents - pharmacology Transcription Factors - genetics Transcription Factors - metabolism Wnt protein Wnt Proteins - genetics Wnt Proteins - metabolism β-Catenin
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