C282Y-HFE gene variant affects cholesterol metabolism in human neuroblastoma cells

Although disruptions in the maintenance of iron and cholesterol metabolism have been implicated in several cancers, the association between variants in the HFE gene that is associated with cellular iron uptake and cholesterol metabolism has not been studied. The C282Y-HFE variant is a risk factor fo...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e88724
Hauptverfasser:	Ali-Rahmani, Fatima, Huang, Michael A, Schengrund, C-L, Connor, James R, Lee, Sang Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Androstenes - chemistry Apolipoproteins Apoptosis Azetidines - chemistry Biology Biosynthesis Cancer Cancer research Cell adhesion & migration Cell culture Cell growth Cell Line, Tumor Cell Survival Cholesterol Cholesterol - metabolism Enzyme inhibitors Ezetimibe Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genetic aspects Genetic Variation Health aspects Health risks Hemochromatosis Protein HFE protein Histocompatibility Antigens Class I - genetics Humans Inhibitors Iron Iron - metabolism Kinases Lipid metabolism Lipids Medicine Membrane Proteins - genetics Metabolism Metabolites Neuroblastoma Neuroblastoma - genetics Neuroblastoma cells Neurosurgery Npc1 protein Oxidoreductases - antagonists & inhibitors Oxidoreductases - metabolism Phenotype Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Prostate cancer Proteins Reductase Risk Factors Signal transduction Simvastatin Simvastatin - chemistry Sphingolipids - metabolism Sphingosine Sphingosine kinase Studies Transcription Transcription (Genetics) Trends Tumor cells Viability
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