Adenoviruses associated with acute diarrhea in children in Beijing, China
Adenoviruses have been recognized as important causal pathogens of community-acquired diarrhea (CAD) among children, but their role in hospital-acquired diarrhea (HAD) is not well-understood. Hospitalized children with acute diarrhea and children who visited the outpatient department due to diarrhea...
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| description | Adenoviruses have been recognized as important causal pathogens of community-acquired diarrhea (CAD) among children, but their role in hospital-acquired diarrhea (HAD) is not well-understood. Hospitalized children with acute diarrhea and children who visited the outpatient department due to diarrhea were investigated from 2011 to 2012. Adenovirus was detected in stool specimens by PCR and further characterized by sequencing and phylogenetic analysis. SPSS software (version 19.0) was used for statistical analyses. A total of 2233 diarrheal children were enrolled in this study; this sample was comprised of 1371 hospitalized children, including 885 with CAD (IP-CAD) and 486 with HAD, and 862 outpatients with CAD (OP-CAD). Among these 2,233 patients, adenovirus was detected in 219 cases (9.8%). The positive rates for adenovirus were significantly different between the IP-CAD (9.3%), HAD (13.8%) and OP-CAD (8.1%) cases (X² = 11.76, p = 0.003). The positive rate of adenovirus was lower in infants under six months of age compared to the positive rates in the other age groups. Of the 219 of adenovirus positive patients, 91 (41.6%) were identified as having serotype 41. Although enteric adenovirus (group F) was the most frequently detected adenovirus among children with either CAD or HAD, the role of non-enteric adenoviruses, especially the adenovirus 31 type (19.7%), cannot be ignored in diarrheal children. |
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Hospitalized children with acute diarrhea and children who visited the outpatient department due to diarrhea were investigated from 2011 to 2012. Adenovirus was detected in stool specimens by PCR and further characterized by sequencing and phylogenetic analysis. SPSS software (version 19.0) was used for statistical analyses. A total of 2233 diarrheal children were enrolled in this study; this sample was comprised of 1371 hospitalized children, including 885 with CAD (IP-CAD) and 486 with HAD, and 862 outpatients with CAD (OP-CAD). Among these 2,233 patients, adenovirus was detected in 219 cases (9.8%). The positive rates for adenovirus were significantly different between the IP-CAD (9.3%), HAD (13.8%) and OP-CAD (8.1%) cases (X² = 11.76, p = 0.003). The positive rate of adenovirus was lower in infants under six months of age compared to the positive rates in the other age groups. Of the 219 of adenovirus positive patients, 91 (41.6%) were identified as having serotype 41. Although enteric adenovirus (group F) was the most frequently detected adenovirus among children with either CAD or HAD, the role of non-enteric adenoviruses, especially the adenovirus 31 type (19.7%), cannot be ignored in diarrheal children.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0088791</identifier><identifier>PMID: 24533149</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute Disease - epidemiology ; Acute Disease - therapy ; Adenoviridae - isolation & purification ; Adenoviridae - physiology ; Adenoviruses ; Age ; Age Distribution ; Ambulatory Care - statistics & numerical data ; Analysis ; Biology ; Child ; Children ; China - epidemiology ; Cladistic analysis ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - therapy ; Community-Acquired Infections - virology ; Consent ; Cross infection ; Diarrhea ; Diarrhea - epidemiology ; Diarrhea - therapy ; Diarrhea - virology ; Epidemiology ; Ethics ; Feces ; Female ; Hospitalization ; Hospitalization - statistics & numerical data ; Humans ; Identification ; Infants ; Laboratories ; Male ; Medicine ; Nosocomial infections ; Patients ; Pediatrics ; Phylogenetics ; Phylogeny ; Sex Distribution ; Statistical analysis ; Studies ; Viral proteins ; Virology ; Viruses</subject><ispartof>PloS one, 2014-02, Vol.9 (2), p.e88791-e88791</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Liu et al 2014 Liu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8db119ec8daaf8af6289751a4f42428ab3f8234344b1db16aa88fb83e43721723</citedby><cites>FETCH-LOGICAL-c692t-8db119ec8daaf8af6289751a4f42428ab3f8234344b1db16aa88fb83e43721723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923065/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923065/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24533149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Alazawi, William</contributor><creatorcontrib>Liu, Liying</creatorcontrib><creatorcontrib>Qian, Yuan</creatorcontrib><creatorcontrib>Zhang, You</creatorcontrib><creatorcontrib>Deng, Jie</creatorcontrib><creatorcontrib>Jia, Liping</creatorcontrib><creatorcontrib>Dong, Huijin</creatorcontrib><title>Adenoviruses associated with acute diarrhea in children in Beijing, China</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Adenoviruses have been recognized as important causal pathogens of community-acquired diarrhea (CAD) among children, but their role in hospital-acquired diarrhea (HAD) is not well-understood. Hospitalized children with acute diarrhea and children who visited the outpatient department due to diarrhea were investigated from 2011 to 2012. Adenovirus was detected in stool specimens by PCR and further characterized by sequencing and phylogenetic analysis. SPSS software (version 19.0) was used for statistical analyses. A total of 2233 diarrheal children were enrolled in this study; this sample was comprised of 1371 hospitalized children, including 885 with CAD (IP-CAD) and 486 with HAD, and 862 outpatients with CAD (OP-CAD). Among these 2,233 patients, adenovirus was detected in 219 cases (9.8%). The positive rates for adenovirus were significantly different between the IP-CAD (9.3%), HAD (13.8%) and OP-CAD (8.1%) cases (X² = 11.76, p = 0.003). The positive rate of adenovirus was lower in infants under six months of age compared to the positive rates in the other age groups. Of the 219 of adenovirus positive patients, 91 (41.6%) were identified as having serotype 41. Although enteric adenovirus (group F) was the most frequently detected adenovirus among children with either CAD or HAD, the role of non-enteric adenoviruses, especially the adenovirus 31 type (19.7%), cannot be ignored in diarrheal children.</description><subject>Acute Disease - epidemiology</subject><subject>Acute Disease - therapy</subject><subject>Adenoviridae - isolation & purification</subject><subject>Adenoviridae - physiology</subject><subject>Adenoviruses</subject><subject>Age</subject><subject>Age Distribution</subject><subject>Ambulatory Care - statistics & numerical data</subject><subject>Analysis</subject><subject>Biology</subject><subject>Child</subject><subject>Children</subject><subject>China - epidemiology</subject><subject>Cladistic analysis</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Community-Acquired Infections - therapy</subject><subject>Community-Acquired Infections - virology</subject><subject>Consent</subject><subject>Cross infection</subject><subject>Diarrhea</subject><subject>Diarrhea - epidemiology</subject><subject>Diarrhea - therapy</subject><subject>Diarrhea - virology</subject><subject>Epidemiology</subject><subject>Ethics</subject><subject>Feces</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Identification</subject><subject>Infants</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicine</subject><subject>Nosocomial infections</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Sex Distribution</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Viral proteins</subject><subject>Virology</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QLgig4Y77apjfCOPgxsLDg1204TdJphk4ym6S7678343SXqeyF5CKH5DnvyTl5s-w5RnNMK_x-4wZvoZ_vnNVzhDivavwgO8U1JbOSIPrwKD7JnoSwQaigvCwfZyeEFZRiVp9mq4XS1l0ZPwQdcgjBSQNRq_zaxC4HOUSdKwPedxpyY3PZmV55bffxR202xq7f5cvOWHiaPWqhD_rZuJ9lPz9_-rH8Oju_-LJaLs5nsqxJnHHVYFxryRVAy6EtCa-rAgNrGWGEQ0NbTiijjDU4oSUA523DqWa0Irgi9Cx7edDd9S6IcQpBpG4qWhcVqxOxOhDKwUbsvNmC_y0cGPH3wPm1AB-N7LWQDUUNUKQ4AlZWiuMi1UtBWwHXqklaH8ZqQ7PVSmobPfQT0emNNZ1YuytBa0JRWSSBN6OAd5eDDlFsTZC678FqN6R3FwiVNSvwvrNX_6D3dzdSa0gNGNu6VFfuRcWCVZyjMn17oub3UGkpvTUyWaY16XyS8HaSkJiob-IahhDE6vu3_2cvfk3Z10dsclEfu-D6IRpnwxRkB1B6F4LX7d2QMRJ7x99OQ-wdL0bHp7QXxx90l3RrcfoHCkT6Xg</recordid><startdate>20140212</startdate><enddate>20140212</enddate><creator>Liu, Liying</creator><creator>Qian, Yuan</creator><creator>Zhang, You</creator><creator>Deng, Jie</creator><creator>Jia, Liping</creator><creator>Dong, Huijin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140212</creationdate><title>Adenoviruses associated with acute diarrhea in children in Beijing, China</title><author>Liu, Liying ; Qian, Yuan ; Zhang, You ; Deng, Jie ; Jia, Liping ; Dong, Huijin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-8db119ec8daaf8af6289751a4f42428ab3f8234344b1db16aa88fb83e43721723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute Disease - epidemiology</topic><topic>Acute Disease - therapy</topic><topic>Adenoviridae - isolation & purification</topic><topic>Adenoviridae - physiology</topic><topic>Adenoviruses</topic><topic>Age</topic><topic>Age Distribution</topic><topic>Ambulatory Care - statistics & numerical data</topic><topic>Analysis</topic><topic>Biology</topic><topic>Child</topic><topic>Children</topic><topic>China - epidemiology</topic><topic>Cladistic analysis</topic><topic>Community-Acquired Infections - epidemiology</topic><topic>Community-Acquired Infections - therapy</topic><topic>Community-Acquired Infections - virology</topic><topic>Consent</topic><topic>Cross infection</topic><topic>Diarrhea</topic><topic>Diarrhea - epidemiology</topic><topic>Diarrhea - therapy</topic><topic>Diarrhea - virology</topic><topic>Epidemiology</topic><topic>Ethics</topic><topic>Feces</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Identification</topic><topic>Infants</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medicine</topic><topic>Nosocomial infections</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Phylogenetics</topic><topic>Phylogeny</topic><topic>Sex Distribution</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Viral proteins</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Liying</creatorcontrib><creatorcontrib>Qian, Yuan</creatorcontrib><creatorcontrib>Zhang, You</creatorcontrib><creatorcontrib>Deng, Jie</creatorcontrib><creatorcontrib>Jia, Liping</creatorcontrib><creatorcontrib>Dong, Huijin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Liying</au><au>Qian, Yuan</au><au>Zhang, You</au><au>Deng, Jie</au><au>Jia, Liping</au><au>Dong, Huijin</au><au>Alazawi, William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adenoviruses associated with acute diarrhea in children in Beijing, China</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-02-12</date><risdate>2014</risdate><volume>9</volume><issue>2</issue><spage>e88791</spage><epage>e88791</epage><pages>e88791-e88791</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Adenoviruses have been recognized as important causal pathogens of community-acquired diarrhea (CAD) among children, but their role in hospital-acquired diarrhea (HAD) is not well-understood. Hospitalized children with acute diarrhea and children who visited the outpatient department due to diarrhea were investigated from 2011 to 2012. Adenovirus was detected in stool specimens by PCR and further characterized by sequencing and phylogenetic analysis. SPSS software (version 19.0) was used for statistical analyses. A total of 2233 diarrheal children were enrolled in this study; this sample was comprised of 1371 hospitalized children, including 885 with CAD (IP-CAD) and 486 with HAD, and 862 outpatients with CAD (OP-CAD). Among these 2,233 patients, adenovirus was detected in 219 cases (9.8%). The positive rates for adenovirus were significantly different between the IP-CAD (9.3%), HAD (13.8%) and OP-CAD (8.1%) cases (X² = 11.76, p = 0.003). The positive rate of adenovirus was lower in infants under six months of age compared to the positive rates in the other age groups. Of the 219 of adenovirus positive patients, 91 (41.6%) were identified as having serotype 41. Although enteric adenovirus (group F) was the most frequently detected adenovirus among children with either CAD or HAD, the role of non-enteric adenoviruses, especially the adenovirus 31 type (19.7%), cannot be ignored in diarrheal children.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24533149</pmid><doi>10.1371/journal.pone.0088791</doi><tpages>e88791</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease - epidemiology Acute Disease - therapy Adenoviridae - isolation & purification Adenoviridae - physiology Adenoviruses Age Age Distribution Ambulatory Care - statistics & numerical data Analysis Biology Child Children China - epidemiology Cladistic analysis Community-Acquired Infections - epidemiology Community-Acquired Infections - therapy Community-Acquired Infections - virology Consent Cross infection Diarrhea Diarrhea - epidemiology Diarrhea - therapy Diarrhea - virology Epidemiology Ethics Feces Female Hospitalization Hospitalization - statistics & numerical data Humans Identification Infants Laboratories Male Medicine Nosocomial infections Patients Pediatrics Phylogenetics Phylogeny Sex Distribution Statistical analysis Studies Viral proteins Virology Viruses |
| title | Adenoviruses associated with acute diarrhea in children in Beijing, China |
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