Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells

We have used an in vitro model system to probe the iron transport pathway across the brain microvascular endothelial cells (BMVEC) of the blood-brain barrier (BBB). This model consists of human BMVEC (hBMVEC) and C6 glioma cells (as an astrocytic cell line) grown in a transwell, a cell culture syste...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e89003-e89003
Hauptverfasser:	McCarthy, Ryan C, Kosman, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Alzheimers disease Analysis Astrocytes Astrocytes - cytology Astrocytes - metabolism Biochemistry Biology Blood-brain barrier Blood-Brain Barrier - metabolism Brain Brain - blood supply Brain tumors Cation Transport Proteins - metabolism Cell culture Cell Line Cells (Biology) Ceruloplasmin Ceruloplasmin - chemistry Ceruloplasmin - metabolism Copper Efflux Endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Endothelium Exports Ferroxidase Gene expression Glioma Glioma cells Gliomas Hepcidin Hepcidins - genetics Hepcidins - metabolism Homeostasis Humans Internalization Iron Iron - metabolism Iron transport Mammalian cells Medicine Metabolites Microvasculature Microvessels - cytology mRNA Mutation Neuroglia - cytology Neuroglia - metabolism Oxidative stress Paracrine Communication Permease Protein Transport Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Secretion Solubility Transferrin Transferrins Ubiquitination Up-Regulation
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