Using the PfEMP1 head structure binding motif to deal a blow at severe malaria
Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to ∼1 million deaths and ∼100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rose...
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| Veröffentlicht in: | PloS one 2014-02, Vol.9 (2), p.e88420-e88420 |
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| creator | Patarroyo, Manuel E Alba, Martha Patricia Curtidor, Hernando Vanegas, Magnolia Almonacid, Hannia Patarroyo, Manuel A |
| description | Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to ∼1 million deaths and ∼100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this ∼300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria. |
| doi_str_mv | 10.1371/journal.pone.0088420 |
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Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this ∼300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0088420</identifier><identifier>PMID: 24516657</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Antigens ; Aotidae ; Binding ; Biology ; Chemistry ; Chondroitin sulfate ; Chondroitin Sulfates - metabolism ; Conserved sequence ; Endothelial cells ; Erythrocyte membrane protein 1 ; Erythrocytes ; Erythrocytes - immunology ; Erythrocytes - metabolism ; Health sciences ; Humans ; Hydrogen bonds ; Immunity ; Immunization ; Immunoglobulins ; Laboratory animals ; Malaria ; Malaria Vaccines - immunology ; Malaria, Falciparum - immunology ; Malaria, Falciparum - metabolism ; Malaria, Falciparum - prevention & control ; Medicine ; Membrane proteins ; Monkeys ; Monkeys & apes ; Parasites ; Peptides ; Plasmodium falciparum ; Pregnancy ; Protein Binding - immunology ; Proteins ; Protozoan Proteins - metabolism ; Rosette formation ; Sulfates ; Vector-borne diseases ; Veterinarians</subject><ispartof>PloS one, 2014-02, Vol.9 (2), p.e88420-e88420</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Patarroyo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Patarroyo et al 2014 Patarroyo et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-41ebd135e73270a7a2d9cbc77c719416d07d8791362885189d3dea4a4be39eec3</citedby><cites>FETCH-LOGICAL-c692t-41ebd135e73270a7a2d9cbc77c719416d07d8791362885189d3dea4a4be39eec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917906/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917906/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24516657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mariño-Ramírez, Leonardo</contributor><creatorcontrib>Patarroyo, Manuel E</creatorcontrib><creatorcontrib>Alba, Martha Patricia</creatorcontrib><creatorcontrib>Curtidor, Hernando</creatorcontrib><creatorcontrib>Vanegas, Magnolia</creatorcontrib><creatorcontrib>Almonacid, Hannia</creatorcontrib><creatorcontrib>Patarroyo, Manuel A</creatorcontrib><title>Using the PfEMP1 head structure binding motif to deal a blow at severe malaria</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to ∼1 million deaths and ∼100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this ∼300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria.</description><subject>Animals</subject><subject>Antigens</subject><subject>Aotidae</subject><subject>Binding</subject><subject>Biology</subject><subject>Chemistry</subject><subject>Chondroitin sulfate</subject><subject>Chondroitin Sulfates - metabolism</subject><subject>Conserved sequence</subject><subject>Endothelial cells</subject><subject>Erythrocyte membrane protein 1</subject><subject>Erythrocytes</subject><subject>Erythrocytes - immunology</subject><subject>Erythrocytes - metabolism</subject><subject>Health sciences</subject><subject>Humans</subject><subject>Hydrogen bonds</subject><subject>Immunity</subject><subject>Immunization</subject><subject>Immunoglobulins</subject><subject>Laboratory animals</subject><subject>Malaria</subject><subject>Malaria Vaccines - 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metabolism</topic><topic>Conserved sequence</topic><topic>Endothelial cells</topic><topic>Erythrocyte membrane protein 1</topic><topic>Erythrocytes</topic><topic>Erythrocytes - immunology</topic><topic>Erythrocytes - metabolism</topic><topic>Health sciences</topic><topic>Humans</topic><topic>Hydrogen bonds</topic><topic>Immunity</topic><topic>Immunization</topic><topic>Immunoglobulins</topic><topic>Laboratory animals</topic><topic>Malaria</topic><topic>Malaria Vaccines - immunology</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - metabolism</topic><topic>Malaria, Falciparum - prevention & control</topic><topic>Medicine</topic><topic>Membrane proteins</topic><topic>Monkeys</topic><topic>Monkeys & apes</topic><topic>Parasites</topic><topic>Peptides</topic><topic>Plasmodium falciparum</topic><topic>Pregnancy</topic><topic>Protein Binding - immunology</topic><topic>Proteins</topic><topic>Protozoan Proteins - metabolism</topic><topic>Rosette formation</topic><topic>Sulfates</topic><topic>Vector-borne diseases</topic><topic>Veterinarians</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patarroyo, Manuel E</creatorcontrib><creatorcontrib>Alba, Martha Patricia</creatorcontrib><creatorcontrib>Curtidor, Hernando</creatorcontrib><creatorcontrib>Vanegas, Magnolia</creatorcontrib><creatorcontrib>Almonacid, Hannia</creatorcontrib><creatorcontrib>Patarroyo, Manuel A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patarroyo, Manuel E</au><au>Alba, Martha Patricia</au><au>Curtidor, Hernando</au><au>Vanegas, Magnolia</au><au>Almonacid, Hannia</au><au>Patarroyo, Manuel A</au><au>Mariño-Ramírez, Leonardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using the PfEMP1 head structure binding motif to deal a blow at severe malaria</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-02-07</date><risdate>2014</risdate><volume>9</volume><issue>2</issue><spage>e88420</spage><epage>e88420</epage><pages>e88420-e88420</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to ∼1 million deaths and ∼100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this ∼300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24516657</pmid><doi>10.1371/journal.pone.0088420</doi><tpages>e88420</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antigens Aotidae Binding Biology Chemistry Chondroitin sulfate Chondroitin Sulfates - metabolism Conserved sequence Endothelial cells Erythrocyte membrane protein 1 Erythrocytes Erythrocytes - immunology Erythrocytes - metabolism Health sciences Humans Hydrogen bonds Immunity Immunization Immunoglobulins Laboratory animals Malaria Malaria Vaccines - immunology Malaria, Falciparum - immunology Malaria, Falciparum - metabolism Malaria, Falciparum - prevention & control Medicine Membrane proteins Monkeys Monkeys & apes Parasites Peptides Plasmodium falciparum Pregnancy Protein Binding - immunology Proteins Protozoan Proteins - metabolism Rosette formation Sulfates Vector-borne diseases Veterinarians |
| title | Using the PfEMP1 head structure binding motif to deal a blow at severe malaria |
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